HNF1A (HNF1 homeobox A)

Identity

Other names	HNF1
	LFB1
	MODY3
	TCF1
HGNC	HNF1A
Location	12q24.31
Location_base_pair	Starts at 119900932 and ends at 119924697 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	HNF1A   11621
Entrez_Gene	HNF1A  6927  HNF1 homeobox A
	Cards
GeneCards	HNF1A
Ensembl	HNF1A [Search_View]   ENSG00000135100 [Gene_View]
Genatlas	HNF1A
GeneLynx	HNF1A
eGenome	HNF1A
euGene	6927
	Genomic and cartography
GoldenPath	HNF1A  -  12q24.31   chr12:119900932-119924697 +  12q24.31   [Description]    (hg18-March_2006)
Ensembl	HNF1A - 12q24.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	HNF1A
	Gene and transcription
Genbank	AW294801 [ ENTREZ ]
Genbank	BC104908 [ ENTREZ ]
Genbank	BC104910 [ ENTREZ ]
Genbank	BE348240 [ ENTREZ ]
Genbank	BM854591 [ ENTREZ ]
RefSeq	NM_000545 [ SRS ]    NM_000545 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009775 [ SRS ]    NT_009775 [ ENTREZ ]
RefSeq	NW_001838063 [ SRS ]    NW_001838063 [ ENTREZ ]
RefSeq	NW_925395 [ SRS ]    NW_925395 [ ENTREZ ]
AceView	HNF1A AceView - NCBI
Unigene	Hs.654455 [ SRS ]    Hs.654455 [ NCBI ]     HS654455 [ spliceNest ]
Fast-db	14205 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P20823 [ SRS]    P20823 [ EXPASY ]     P20823 [ INTERPRO ]     P20823 [ UNIPROT ]
Prosite	PS00027 HOMEOBOX_1 [ SRS ]    PS00027 HOMEOBOX_1 [ Expasy ]
Prosite	PS50071 HOMEOBOX_2 [ SRS ]    PS50071 HOMEOBOX_2 [ Expasy ]
Interpro	IPR006899 HNF-1_N [ SRS ]    IPR006899 HNF-1_N [ EBI ]
Interpro	IPR006898 HNF1a_C [ SRS ]    IPR006898 HNF1a_C [ EBI ]
Interpro	IPR006897 HNF1b_C [ SRS ]    IPR006897 HNF1b_C [ EBI ]
Interpro	IPR001356 Homeobox [ SRS ]    IPR001356 Homeobox [ EBI ]
Interpro	IPR012287 Homeodomain-rel [ SRS ]    IPR012287 Homeodomain-rel [ EBI ]
CluSTr	P20823
Pfam	PF04814 HNF-1_N [ SRS ]    PF04814 HNF-1_N [ Sanger ]    pfam04814 [ NCBI-CDD ]
Pfam	PF04813 HNF-1A_C [ SRS ]    PF04813 HNF-1A_C [ Sanger ]    pfam04813 [ NCBI-CDD ]
Pfam	PF04812 HNF-1B_C [ SRS ]    PF04812 HNF-1B_C [ Sanger ]    pfam04812 [ NCBI-CDD ]
Pfam	PF00046 Homeobox [ SRS ]    PF00046 Homeobox [ Sanger ]    pfam00046 [ NCBI-CDD ]
Smart	SM00389 HOX [EMBL]
Prodom	PD000010 Homeobox[INRA-Toulouse]
Prodom	P20823 HNF1A_HUMAN [ Domain structure ]   P20823 HNF1A_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P20823
PDB	1IC8 [ SRS ]    1IC8 [ PdbSum ],   1IC8 [ IMB ]   1IC8 [ RSDB ]
HPRD	00800
	Protein Interaction databases
DIP	P20823
IntAct	P20823
	Polymorphism : SNP, mutations, diseases
OMIM	125853;142330;142410;144700;222100;600496    [ map ]
GENECLINICS	125853;142330;142410;144700;222100;600496
SNP	HNF1A [dbSNP-NCBI]
SNP	NM_000545 [SNP-NCI]
SNP	HNF1A [GeneSNPs - Utah]  HNF1A] [HGBASE - SRS]
HAPMAP	HNF1A [HAPMAP]
COSMIC	HNF1A [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	HNF1A
	General knowledge
Family Browser	HNF1A [UCSC Family Browser]
SOURCE	NM_000545
SMD	Hs.654455
SAGE	Hs.654455
GO	transcription factor activity [Amigo]  transcription factor activity
GO	RNA polymerase II transcription factor activity [Amigo]  RNA polymerase II transcription factor activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	regulation of specific transcription from RNA polymerase II promoter [Amigo]  regulation of specific transcription from RNA polymerase II promoter
GO	transcription activator activity [Amigo]  transcription activator activity
GO	glucose homeostasis [Amigo]  glucose homeostasis
GO	protein complex [Amigo]  protein complex
GO	sequence-specific DNA binding [Amigo]  sequence-specific DNA binding
GO	positive regulation of transcription, DNA-dependent [Amigo]  positive regulation of transcription, DNA-dependent
KEGG	Maturity onset diabetes of the young
PubGene	HNF1A
TreeFam	HNF1A
CTD	6927 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	HNF1A Related clones (RZPD - Berlin)
	PubMed
PubMed	182 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:16:22 2008