Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
HNF-1A,HNF1,HNF1alpha,HNF4A,IDDM20,LFB1,MODY3,TCF-1,TCF1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6927
MIM: 142410
HGNC: 11621
Ensembl: ENSG00000135100
Variants:
dbSNP: 6927
ClinVar: 6927
TCGA: ENSG00000135100
COSMIC: HNF1A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24684 | AKT1 | Gene | Pathway | associated | |||
| PA452618 | opioids | Chemical | MultilinkAnnotation | associated | 26233334 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38494066 | 2024 | HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway. | 0 |
| 38632103 | 2024 | Effect of mutation at c.493T>C locus of transcription factor HNF1α gene on its protein level. | 0 |
| 38855865 | 2024 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. | 0 |
| 38879600 | 2024 | Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α. | 0 |
| 38494066 | 2024 | HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway. | 0 |
| 38632103 | 2024 | Effect of mutation at c.493T>C locus of transcription factor HNF1α gene on its protein level. | 0 |
| 38855865 | 2024 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. | 0 |
| 38879600 | 2024 | Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α. | 0 |
| 35944095 | 2023 | HNF1A regulates the crosstalk between innate immune responses and MAFLD by mediating autophagic degradation of TBK1. | 3 |
| 36216889 | 2023 | The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations. | 0 |
| 36331708 | 2023 | HNF1α upregulation and promoter hypermethylation as a cause of glucose dysregulation: a case-control study of Kashmiri MODY population. | 0 |
| 36380687 | 2023 | YTHDF3 mediates HNF1α regulation of cervical cancer radio-resistance by promoting RAD51D translation in an m6A-dependent manner. | 9 |
| 37137894 | 2023 | HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells. | 2 |
| 37219942 | 2023 | High-fat diet plus HNF1A variant promotes polyps by activating β-catenin in early-onset colorectal cancer. | 3 |
| 37396188 | 2023 | Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine. | 0 |
Citation
Dessen P
HNF1A (HNF1 homeobox A)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/470/hnf1a
