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HNMT (histamine N-methyltransferase)

Identity

Other aliasHMT
HNMT-S1
HNMT-S2
MRT51
HGNC (Hugo) HNMT
LocusID (NCBI) 3176
Atlas_Id 52107
Location 2q22.1  [Link to chromosome band 2q22]
Location_base_pair Starts at 138721808 and ends at 138725014 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MGAT5 (2q21.2) / HNMT (2q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)HNMT   5028
Cards
Entrez_Gene (NCBI)HNMT  3176  histamine N-methyltransferase
AliasesHMT; HNMT-S1; HNMT-S2; MRT51
GeneCards (Weizmann)HNMT
Ensembl hg19 (Hinxton)ENSG00000150540 [Gene_View]  chr2:138721808-138725014 [Contig_View]  HNMT [Vega]
Ensembl hg38 (Hinxton)ENSG00000150540 [Gene_View]  chr2:138721808-138725014 [Contig_View]  HNMT [Vega]
ICGC DataPortalENSG00000150540
TCGA cBioPortalHNMT
AceView (NCBI)HNMT
Genatlas (Paris)HNMT
WikiGenes3176
SOURCE (Princeton)HNMT
Genetics Home Reference (NIH)HNMT
Genomic and cartography
GoldenPath hg19 (UCSC)HNMT  -     chr2:138721808-138725014 +  2q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HNMT  -     2q22.1   [Description]    (hg38-Dec_2013)
EnsemblHNMT - 2q22.1 [CytoView hg19]  HNMT - 2q22.1 [CytoView hg38]
Mapping of homologs : NCBIHNMT [Mapview hg19]  HNMT [Mapview hg38]
OMIM600807   605238   
Gene and transcription
Genbank (Entrez)AA935821 AF523356 AF523357 AF523358 AF523359
RefSeq transcript (Entrez)NM_001024074 NM_001024075 NM_006895
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_012966 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)HNMT
Cluster EST : UnigeneHs.42151 [ NCBI ]
CGAP (NCI)Hs.42151
Alternative Splicing GalleryENSG00000150540
Gene ExpressionHNMT [ NCBI-GEO ]   HNMT [ EBI - ARRAY_EXPRESS ]   HNMT [ SEEK ]   HNMT [ MEM ]
Gene Expression Viewer (FireBrowse)HNMT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3176
GTEX Portal (Tissue expression)HNMT
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50135   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50135  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50135
Splice isoforms : SwissVarP50135
PhosPhoSitePlusP50135
Domaine pattern : Prosite (Expaxy)SAM_HNMT (PS51597)   
Domains : Interpro (EBI)HHMT-like    SAM-dependent_MTases   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)HNMT
DMDM Disease mutations3176
Blocks (Seattle)HNMT
PDB (SRS)1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
PDB (PDBSum)1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
PDB (IMB)1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
PDB (RSDB)1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
Structural Biology KnowledgeBase1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
SCOP (Structural Classification of Proteins)1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
CATH (Classification of proteins structures)1ICZ    1JQD    1JQE    2AOT    2AOU    2AOV    2AOW    2AOX   
SuperfamilyP50135
Human Protein AtlasENSG00000150540
Peptide AtlasP50135
HPRD05575
IPIIPI00030023   IPI00216650   IPI00029307   
Protein Interaction databases
DIP (DOE-UCLA)P50135
IntAct (EBI)P50135
FunCoupENSG00000150540
BioGRIDHNMT
STRING (EMBL)HNMT
ZODIACHNMT
Ontologies - Pathways
QuickGOP50135
Ontology : AmiGOresponse to tumor cell  nucleoplasm  cytoplasm  cytosol  histidine catabolic process  hyperosmotic response  brain development  respiratory gaseous exchange  response to amine  methylation  response to immobilization stress  response to cocaine  neuron projection  histamine N-methyltransferase activity  histamine N-methyltransferase activity  response to glucocorticoid  extracellular exosome  response to interleukin-1  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIresponse to tumor cell  nucleoplasm  cytoplasm  cytosol  histidine catabolic process  hyperosmotic response  brain development  respiratory gaseous exchange  response to amine  methylation  response to immobilization stress  response to cocaine  neuron projection  histamine N-methyltransferase activity  histamine N-methyltransferase activity  response to glucocorticoid  extracellular exosome  response to interleukin-1  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGHistidine metabolism   
NDEx NetworkHNMT
Atlas of Cancer Signalling NetworkHNMT
Wikipedia pathwaysHNMT
Orthology - Evolution
OrthoDB3176
GeneTree (enSembl)ENSG00000150540
Phylogenetic Trees/Animal Genes : TreeFamHNMT
HOVERGENP50135
HOGENOMP50135
Homologs : HomoloGeneHNMT
Homology/Alignments : Family Browser (UCSC)HNMT
Gene fusions - Rearrangements
Fusion : MitelmanMGAT5/HNMT [2q21.2/2q22.1]  [t(2;2)(q21;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHNMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HNMT
dbVarHNMT
ClinVarHNMT
1000_GenomesHNMT 
Exome Variant ServerHNMT
ExAC (Exome Aggregation Consortium)HNMT (select the gene name)
Genetic variants : HAPMAP3176
Genomic Variants (DGV)HNMT [DGVbeta]
DECIPHER (Syndromes)2:138721808-138725014  ENSG00000150540
CONAN: Copy Number AnalysisHNMT 
Mutations
ICGC Data PortalHNMT 
TCGA Data PortalHNMT 
Broad Tumor PortalHNMT
OASIS PortalHNMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHNMT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHNMT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HNMT
DgiDB (Drug Gene Interaction Database)HNMT
DoCM (Curated mutations)HNMT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HNMT (select a term)
intoGenHNMT
Cancer3DHNMT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600807    605238   
Orphanet11804   
MedgenHNMT
Genetic Testing Registry HNMT
NextProtP50135 [Medical]
TSGene3176
GENETestsHNMT
Huge Navigator HNMT [HugePedia]
snp3D : Map Gene to Disease3176
BioCentury BCIQHNMT
ClinGenHNMT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3176
Chemical/Pharm GKB GenePA190
Clinical trialHNMT
Miscellaneous
canSAR (ICR)HNMT (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHNMT
EVEXHNMT
GoPubMedHNMT
iHOPHNMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:04:02 CEST 2017

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