Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1)

Identity

Alias_namesHNRPA2B1
Other aliasHNRNPA2
HNRNPB1
HNRPA2
HNRPB1
IBMPFD2
RNPA2
SNRPB1
HGNC (Hugo) HNRNPA2B1
LocusID (NCBI) 3181
Atlas_Id 46209
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 26189936 and ends at 26200793 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CBFB (16q22.1) / HNRNPA2B1 (7p15.2)DYNC1I2 (2q31.1) / HNRNPA2B1 (7p15.2)EPAS1 (2p21) / HNRNPA2B1 (7p15.2)
ETV1 (7p21.2) / HNRNPA2B1 (7p15.2)EVL (14q32.2) / HNRNPA2B1 (7p15.2)HNRNPA2B1 (7p15.2) / AATF (17q12)
HNRNPA2B1 (7p15.2) / AUTS2 (7q11.22)HNRNPA2B1 (7p15.2) / CANT1 (17q25.3)HNRNPA2B1 (7p15.2) / CBX3 (7p15.2)
HNRNPA2B1 (7p15.2) / CDC5L (6p21.1)HNRNPA2B1 (7p15.2) / EPB41L1 (20q11.23)HNRNPA2B1 (7p15.2) / ETV1 (7p21.2)
HNRNPA2B1 (7p15.2) / ETV6 (12p13.2)HNRNPA2B1 (7p15.2) / FAM96A (15q22.31)HNRNPA2B1 (7p15.2) / H2AFV (7p13)
HNRNPA2B1 (7p15.2) / HNRNPA2B1 (7p15.2)HNRNPA2B1 (7p15.2) / HNRNPUL1 (19q13.2)HNRNPA2B1 (7p15.2) / INS-IGF2 (11p15.5)
HNRNPA2B1 (7p15.2) / LMO7 (13q22.2)HNRNPA2B1 (7p15.2) / NSD1 (5q35.2)HNRNPA2B1 (7p15.2) / PPIA (7p13)
HNRNPA2B1 (7p15.2) / PPP4R2 (3p13)HNRNPA2B1 (7p15.2) / PTMA (2q37.1)HNRNPA2B1 (7p15.2) / RABEP1 (17p13.2)
HNRNPA2B1 (7p15.2) / SHB (9p13.2)HNRNPA2B1 (7p15.2) / SIAE (11q24.2)INS-IGF2 (11p15.5) / HNRNPA2B1 (7p15.2)
JA040725 () / HNRNPA2B1 (7p15.2)KIF13B (8p12) / HNRNPA2B1 (7p15.2)MMP2 (16q12.2) / HNRNPA2B1 (7p15.2)
MYO1E (15q22.2) / HNRNPA2B1 (7p15.2)NOS1AP (1q23.3) / HNRNPA2B1 (7p15.2)PDE6B (4p16.3) / HNRNPA2B1 (7p15.2)
PRR13 (12q13.13) / HNRNPA2B1 (7p15.2)RAD54B (8q22.1) / HNRNPA2B1 (7p15.2)SRSF5 (14q24.2) / HNRNPA2B1 (7p15.2)
SUB1 (5p13.3) / HNRNPA2B1 (7p15.2)VCP (9p13.3) / HNRNPA2B1 (7p15.2)HNRNPA2B1 7p15.2 / ETV1 7p21.2
HNRNPA2B1 7p15.2 / CANT1 17q25.3HNRNPA2B1 7p15.2 / RABEP1 17p13.2HNRNPA2B1 7p15.2 / SIAE 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)HNRNPA2B1   5033
Cards
Entrez_Gene (NCBI)HNRNPA2B1  3181  heterogeneous nuclear ribonucleoprotein A2/B1
AliasesHNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; 
HNRPB1; IBMPFD2; RNPA2; SNRPB1
GeneCards (Weizmann)HNRNPA2B1
Ensembl hg19 (Hinxton)ENSG00000122566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122566 [Gene_View]  chr7:26189936-26200793 [Contig_View]  HNRNPA2B1 [Vega]
ICGC DataPortalENSG00000122566
TCGA cBioPortalHNRNPA2B1
AceView (NCBI)HNRNPA2B1
Genatlas (Paris)HNRNPA2B1
WikiGenes3181
SOURCE (Princeton)HNRNPA2B1
Genetics Home Reference (NIH)HNRNPA2B1
Genomic and cartography
GoldenPath hg38 (UCSC)HNRNPA2B1  -     chr7:26189936-26200793 -  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HNRNPA2B1  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblHNRNPA2B1 - 7p15.2 [CytoView hg19]  HNRNPA2B1 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBIHNRNPA2B1 [Mapview hg19]  HNRNPA2B1 [Mapview hg38]
OMIM600124   615422   
Gene and transcription
Genbank (Entrez)AK026373 AK129839 AK289429 BC000506 BC045724
RefSeq transcript (Entrez)NM_002137 NM_031243
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HNRNPA2B1
Cluster EST : UnigeneHs.487774 [ NCBI ]
CGAP (NCI)Hs.487774
Alternative Splicing GalleryENSG00000122566
Gene ExpressionHNRNPA2B1 [ NCBI-GEO ]   HNRNPA2B1 [ EBI - ARRAY_EXPRESS ]   HNRNPA2B1 [ SEEK ]   HNRNPA2B1 [ MEM ]
Gene Expression Viewer (FireBrowse)HNRNPA2B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3181
GTEX Portal (Tissue expression)HNRNPA2B1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22626   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22626  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22626
Splice isoforms : SwissVarP22626
PhosPhoSitePlusP22626
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)HNRNPA2B1
DMDM Disease mutations3181
Blocks (Seattle)HNRNPA2B1
PDB (SRS)1X4B    5EN1   
PDB (PDBSum)1X4B    5EN1   
PDB (IMB)1X4B    5EN1   
PDB (RSDB)1X4B    5EN1   
Structural Biology KnowledgeBase1X4B    5EN1   
SCOP (Structural Classification of Proteins)1X4B    5EN1   
CATH (Classification of proteins structures)1X4B    5EN1   
SuperfamilyP22626
Human Protein AtlasENSG00000122566
Peptide AtlasP22626
HPRD02526
IPIIPI00396378   IPI00414696   IPI00916517   
Protein Interaction databases
DIP (DOE-UCLA)P22626
IntAct (EBI)P22626
FunCoupENSG00000122566
BioGRIDHNRNPA2B1
STRING (EMBL)HNRNPA2B1
ZODIACHNRNPA2B1
Ontologies - Pathways
QuickGOP22626
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  chromosome, telomeric region  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleoplasm  nucleoplasm  spliceosomal complex  cytoplasm  mRNA processing  mRNA export from nucleus  gene expression  Cajal body  membrane  nuclear matrix  intracellular ribonucleoprotein complex  primary miRNA processing  miRNA binding  single-stranded telomeric DNA binding  G-quadruplex DNA unwinding  negative regulation of mRNA splicing, via spliceosome  RNA transport  extracellular exosome  catalytic step 2 spliceosome  pre-mRNA intronic binding  G-rich strand telomeric DNA binding  positive regulation of telomere maintenance via telomere lengthening  positive regulation of telomerase RNA reverse transcriptase activity  N6-methyladenosine-containing RNA binding  miRNA transport  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  chromosome, telomeric region  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleoplasm  nucleoplasm  spliceosomal complex  cytoplasm  mRNA processing  mRNA export from nucleus  gene expression  Cajal body  membrane  nuclear matrix  intracellular ribonucleoprotein complex  primary miRNA processing  miRNA binding  single-stranded telomeric DNA binding  G-quadruplex DNA unwinding  negative regulation of mRNA splicing, via spliceosome  RNA transport  extracellular exosome  catalytic step 2 spliceosome  pre-mRNA intronic binding  G-rich strand telomeric DNA binding  positive regulation of telomere maintenance via telomere lengthening  positive regulation of telomerase RNA reverse transcriptase activity  N6-methyladenosine-containing RNA binding  miRNA transport  
NDEx NetworkHNRNPA2B1
Atlas of Cancer Signalling NetworkHNRNPA2B1
Wikipedia pathwaysHNRNPA2B1
Orthology - Evolution
OrthoDB3181
GeneTree (enSembl)ENSG00000122566
Phylogenetic Trees/Animal Genes : TreeFamHNRNPA2B1
HOVERGENP22626
HOGENOMP22626
Homologs : HomoloGeneHNRNPA2B1
Homology/Alignments : Family Browser (UCSC)HNRNPA2B1
Gene fusions - Rearrangements
Fusion : MitelmanHNRNPA2B1/CANT1 [7p15.2/17q25.3]  
Fusion : MitelmanHNRNPA2B1/ETV1 [7p15.2/7p21.2]  [t(7;7)(p15;p21)]  
Fusion : MitelmanHNRNPA2B1/RABEP1 [7p15.2/17p13.2]  [t(7;17)(p15;p13)]  
Fusion : MitelmanHNRNPA2B1/SIAE [7p15.2/11q24.2]  [t(7;11)(p15;q24)]  
Fusion: TCGAHNRNPA2B1 7p15.2 CANT1 17q25.3 PRAD
Fusion: TCGAHNRNPA2B1 7p15.2 RABEP1 17p13.2 HNSC
Fusion: TCGAHNRNPA2B1 7p15.2 SIAE 11q24.2 LUAD
Fusion Cancer (Beijing)JA040725 [HNRNPA2B1]  -  7p15.2 [FUSC000829]  [FUSC000829]
Fusion Cancer (Beijing)PDE6B [4p16.3]  -  HNRNPA2B1 [7p15.2]  [FUSC000856]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHNRNPA2B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HNRNPA2B1
dbVarHNRNPA2B1
ClinVarHNRNPA2B1
1000_GenomesHNRNPA2B1 
Exome Variant ServerHNRNPA2B1
ExAC (Exome Aggregation Consortium)HNRNPA2B1 (select the gene name)
Genetic variants : HAPMAP3181
Genomic Variants (DGV)HNRNPA2B1 [DGVbeta]
DECIPHERHNRNPA2B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHNRNPA2B1 
Mutations
ICGC Data PortalHNRNPA2B1 
TCGA Data PortalHNRNPA2B1 
Broad Tumor PortalHNRNPA2B1
OASIS PortalHNRNPA2B1 [ Somatic mutations - Copy number]
Cancer Gene: CensusHNRNPA2B1 
Somatic Mutations in Cancer : COSMICHNRNPA2B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHNRNPA2B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HNRNPA2B1
DgiDB (Drug Gene Interaction Database)HNRNPA2B1
DoCM (Curated mutations)HNRNPA2B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HNRNPA2B1 (select a term)
intoGenHNRNPA2B1
Cancer3DHNRNPA2B1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600124    615422   
Orphanet10698   
MedgenHNRNPA2B1
Genetic Testing Registry HNRNPA2B1
NextProtP22626 [Medical]
TSGene3181
GENETestsHNRNPA2B1
Huge Navigator HNRNPA2B1 [HugePedia]
snp3D : Map Gene to Disease3181
BioCentury BCIQHNRNPA2B1
ClinGenHNRNPA2B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3181
Chemical/Pharm GKB GenePA162391140
Clinical trialHNRNPA2B1
Miscellaneous
canSAR (ICR)HNRNPA2B1 (select the gene name)
Probes
Litterature
PubMed209 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHNRNPA2B1
EVEXHNRNPA2B1
GoPubMedHNRNPA2B1
iHOPHNRNPA2B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:19:10 CEST 2017

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