HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1)

2007-02-01  

Identity

HGNC
LOCATION
7p15.2
LOCUSID
ALIAS
HNRNPA2,HNRNPB1,HNRPA2,HNRPA2B1,HNRPB1,IBMPFD2,RNPA2,SNRPB1
FUSION GENES

Other Information

Locus ID:

NCBI: 3181
MIM: 600124
HGNC: 5033
Ensembl: ENSG00000122566

Variants:

dbSNP: 3181
ClinVar: 3181
TCGA: ENSG00000122566
COSMIC: HNRNPA2B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122566ENST00000354667P22626
ENSG00000122566ENST00000356674P22626
ENSG00000122566ENST00000360787P22626
ENSG00000122566ENST00000608362P22626
ENSG00000122566ENST00000618183A0A087WUI2

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234554232013Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.460
243565092013Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.441
200108082010HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.391
263216802015HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.207
201338372010The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.176
170043212006Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly.59
293580762018Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.56
226282242012Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice.53
277735812016Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45

Citation

Dessen P

HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46209/hnrnpa2b1