HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)

2014-11-01  

Identity

HGNC
LOCATION
2q31.2
LOCUSID
ALIAS
2610510D13Rik,D10S102,FBRNP,HNRPA3
FUSION GENES

Other Information

Locus ID:

NCBI: 220988
MIM: 605372
HGNC: 24941
Ensembl: ENSG00000170144

Variants:

dbSNP: 220988
ClinVar: 220988
TCGA: ENSG00000170144
COSMIC: HNRNPA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170144ENST00000392524P51991
ENSG00000170144ENST00000392524A0A384NL63
ENSG00000170144ENST00000411529P51991
ENSG00000170144ENST00000411529B4DDB6
ENSG00000170144ENST00000432457H7C1J8
ENSG00000170144ENST00000435711P51991
ENSG00000170144ENST00000435711A0A384NL63

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
274612522016Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.13
206003612010Telomeric DNA-binding activities of heterogeneous nuclear ribonucleoprotein A3 in vitro and in vivo.8
238275242013Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis.7
284315752017Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.6
179197482008Heterogeneous nuclear ribonucleoprotein A3 binds single-stranded telomeric DNA and inhibits telomerase extension in vitro.5
225465102012Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals.5
291311082017Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.4
296937452018Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells.3

Citation

Dessen P

HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64368/hnrnpa3