HNRNPC (heterogeneous nuclear ribonucleoprotein C)

2013-11-01  

Identity

HGNC
HNRNPC
LOCATION
14q11.2
LOCUSID
3183
ALIAS
C1,C2,HNRNP,HNRPC,SNRPC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3183
MIM: 164020
HGNC: 5035
Ensembl: ENSG00000092199

Variants:

dbSNP: 3183
ClinVar: 3183
TCGA: ENSG00000092199
COSMIC: HNRNPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092199ENST00000336053B4DY08
ENSG00000092199ENST00000420743P07910
ENSG00000092199ENST00000430246P07910
ENSG00000092199ENST00000449098B2R5W2
ENSG00000092199ENST00000553300P07910
ENSG00000092199ENST00000553753B4DY08
ENSG00000092199ENST00000554383G3V4W0
ENSG00000092199ENST00000554455P07910
ENSG00000092199ENST00000554539G3V5V7
ENSG00000092199ENST00000554891G3V251
ENSG00000092199ENST00000554969P07910
ENSG00000092199ENST00000555137G3V555
ENSG00000092199ENST00000555176G3V5X6
ENSG00000092199ENST00000555215G3V575
ENSG00000092199ENST00000555309G3V2Q1
ENSG00000092199ENST00000555883P07910
ENSG00000092199ENST00000555914G3V4C1
ENSG00000092199ENST00000556142G3V576
ENSG00000092199ENST00000556226G3V3K6
ENSG00000092199ENST00000556513G3V576
ENSG00000092199ENST00000556628P07910
ENSG00000092199ENST00000556897P07910
ENSG00000092199ENST00000557157G3V2D6
ENSG00000092199ENST00000557201P07910
ENSG00000092199ENST00000557336G3V4M8
ENSG00000092199ENST00000557442B4DSU6
ENSG00000092199ENST00000557768G3V2H6

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206019592010iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution.435
257196712015N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.335
233743422013Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements.160
204733142010hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.73
124829812003The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.55
224616162012hnRNP C tetramer measures RNA length to classify RNA polymerase II transcripts for export.53
125094682003Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner.50
239732602013MALAT-1 interacts with hnRNP C in cell cycle regulation.49
157312202005Functional interaction of heterogeneous nuclear ribonucleoprotein C with poliovirus RNA synthesis initiation complexes.48
171599032007A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis.40

Citation

Dessen P

HNRNPC (heterogeneous nuclear ribonucleoprotein C)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53547/hnrnpc