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HNRNPL (heterogeneous nuclear ribonucleoprotein L)

Identity

Alias_namesHNRPL
Other aliasP/OKcl.14
hnRNP-L
HGNC (Hugo) HNRNPL
LocusID (NCBI) 3191
Atlas_Id 52244
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38836388 and ends at 38852339 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTN4 (19q13.2) / HNRNPL (19q13.2)HNRNPL (19q13.2) / ERCC2 (19q13.32)HNRNPL (19q13.2) / HNRNPL (19q13.2)
HNRNPL (19q13.2) / RASSF5 (1q32.1)HNRNPL (19q13.2) / SIRT2 (19q13.2)HNRNPL (19q13.2) / ST3GAL1 (8q24.22)
HNRNPL 19q13.2 / SIRT2 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HNRNPL   5045
Cards
Entrez_Gene (NCBI)HNRNPL  3191  heterogeneous nuclear ribonucleoprotein L
AliasesHNRPL; P/OKcl.14; hnRNP-L
GeneCards (Weizmann)HNRNPL
Ensembl hg19 (Hinxton)ENSG00000104824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104824 [Gene_View]  chr19:38836388-38852339 [Contig_View]  HNRNPL [Vega]
ICGC DataPortalENSG00000104824
TCGA cBioPortalHNRNPL
AceView (NCBI)HNRNPL
Genatlas (Paris)HNRNPL
WikiGenes3191
SOURCE (Princeton)HNRNPL
Genetics Home Reference (NIH)HNRNPL
Genomic and cartography
GoldenPath hg38 (UCSC)HNRNPL  -     chr19:38836388-38852339 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HNRNPL  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblHNRNPL - 19q13.2 [CytoView hg19]  HNRNPL - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIHNRNPL [Mapview hg19]  HNRNPL [Mapview hg38]
OMIM603083   
Gene and transcription
Genbank (Entrez)AB044547 AK092828 AK094966 AK097975 AK292115
RefSeq transcript (Entrez)NM_001005335 NM_001533
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HNRNPL
Cluster EST : UnigeneHs.644906 [ NCBI ]
CGAP (NCI)Hs.644906
Alternative Splicing GalleryENSG00000104824
Gene ExpressionHNRNPL [ NCBI-GEO ]   HNRNPL [ EBI - ARRAY_EXPRESS ]   HNRNPL [ SEEK ]   HNRNPL [ MEM ]
Gene Expression Viewer (FireBrowse)HNRNPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3191
GTEX Portal (Tissue expression)HNRNPL
Human Protein AtlasENSG00000104824-HNRNPL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14866   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14866  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14866
Splice isoforms : SwissVarP14866
PhosPhoSitePlusP14866
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)HnRNP-L/PTB    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)HNRNPL
DMDM Disease mutations3191
Blocks (Seattle)HNRNPL
PDB (SRS)3R27    3TO8   
PDB (PDBSum)3R27    3TO8   
PDB (IMB)3R27    3TO8   
PDB (RSDB)3R27    3TO8   
Structural Biology KnowledgeBase3R27    3TO8   
SCOP (Structural Classification of Proteins)3R27    3TO8   
CATH (Classification of proteins structures)3R27    3TO8   
SuperfamilyP14866
Human Protein Atlas [tissue]ENSG00000104824-HNRNPL [tissue]
Peptide AtlasP14866
HPRD04360
IPIIPI00027834   IPI00909466   IPI01012071   IPI00465225   
Protein Interaction databases
DIP (DOE-UCLA)P14866
IntAct (EBI)P14866
FunCoupENSG00000104824
BioGRIDHNRNPL
STRING (EMBL)HNRNPL
ZODIACHNRNPL
Ontologies - Pathways
QuickGOP14866
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  RNA processing  circadian rhythm  gene expression  membrane  intracellular ribonucleoprotein complex  cellular response to amino acid starvation  ribonucleoprotein granule  transcription regulatory region DNA binding  pronucleus  positive regulation of translation  negative regulation of mRNA splicing, via spliceosome  perinuclear region of cytoplasm  extracellular exosome  pre-mRNA intronic binding  response to peptide  positive regulation of mRNA binding  mRNA CDS binding  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  RNA processing  circadian rhythm  gene expression  membrane  intracellular ribonucleoprotein complex  cellular response to amino acid starvation  ribonucleoprotein granule  transcription regulatory region DNA binding  pronucleus  positive regulation of translation  negative regulation of mRNA splicing, via spliceosome  perinuclear region of cytoplasm  extracellular exosome  pre-mRNA intronic binding  response to peptide  positive regulation of mRNA binding  mRNA CDS binding  
NDEx NetworkHNRNPL
Atlas of Cancer Signalling NetworkHNRNPL
Wikipedia pathwaysHNRNPL
Orthology - Evolution
OrthoDB3191
GeneTree (enSembl)ENSG00000104824
Phylogenetic Trees/Animal Genes : TreeFamHNRNPL
HOVERGENP14866
HOGENOMP14866
Homologs : HomoloGeneHNRNPL
Homology/Alignments : Family Browser (UCSC)HNRNPL
Gene fusions - Rearrangements
Fusion : MitelmanHNRNPL/SIRT2 [19q13.2/19q13.2]  
Fusion: TCGA_MDACCHNRNPL 19q13.2 SIRT2 19q13.2 KIRC
Tumor Fusion PortalHNRNPL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHNRNPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HNRNPL
dbVarHNRNPL
ClinVarHNRNPL
1000_GenomesHNRNPL 
Exome Variant ServerHNRNPL
ExAC (Exome Aggregation Consortium)ENSG00000104824
GNOMAD BrowserENSG00000104824
Genetic variants : HAPMAP3191
Genomic Variants (DGV)HNRNPL [DGVbeta]
DECIPHERHNRNPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHNRNPL 
Mutations
ICGC Data PortalHNRNPL 
TCGA Data PortalHNRNPL 
Broad Tumor PortalHNRNPL
OASIS PortalHNRNPL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHNRNPL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHNRNPL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HNRNPL
DgiDB (Drug Gene Interaction Database)HNRNPL
DoCM (Curated mutations)HNRNPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HNRNPL (select a term)
intoGenHNRNPL
Cancer3DHNRNPL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603083   
Orphanet
DisGeNETHNRNPL
MedgenHNRNPL
Genetic Testing Registry HNRNPL
NextProtP14866 [Medical]
TSGene3191
GENETestsHNRNPL
Target ValidationHNRNPL
Huge Navigator HNRNPL [HugePedia]
snp3D : Map Gene to Disease3191
BioCentury BCIQHNRNPL
ClinGenHNRNPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3191
Chemical/Pharm GKB GenePA162391389
Clinical trialHNRNPL
Miscellaneous
canSAR (ICR)HNRNPL (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHNRNPL
EVEXHNRNPL
GoPubMedHNRNPL
iHOPHNRNPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:16:32 CET 2017

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