HNRNPM (heterogeneous nuclear ribonucleoprotein M)

2009-03-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
CEAR,HNRNPM4,HNRPM,HNRPM4,HTGR1,NAGR1,hnRNP
FUSION GENES

Other Information

Locus ID:

NCBI: 4670
MIM: 160994
HGNC: 5046
Ensembl: ENSG00000099783

Variants:

dbSNP: 4670
ClinVar: 4670
TCGA: ENSG00000099783
COSMIC: HNRNPM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099783ENST00000325495P52272
ENSG00000099783ENST00000348943P52272
ENSG00000099783ENST00000594907M0R2T0
ENSG00000099783ENST00000596295M0R2I7
ENSG00000099783ENST00000596984M0QYQ7
ENSG00000099783ENST00000597270M0QZM1
ENSG00000099783ENST00000598367M0QYL3
ENSG00000099783ENST00000598999M0QY96
ENSG00000099783ENST00000600092M0R019
ENSG00000099783ENST00000600806M0R0Y6
ENSG00000099783ENST00000601645M0R0N3
ENSG00000099783ENST00000620401A0A087X0X3

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
248402022014Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.73
204674372010Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.28
198748202010hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.24
213985162011Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M.20
259266422015Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection.17
187900942008cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.16
245339842014hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7.16
300935602018Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.14
243810812014Identification of HnRNP M as a novel biomarker for colorectal carcinoma by quantitative proteomics.11
256849432015In vitro identification of nonalcoholic fatty liver disease-related protein hnRNPM.10

Citation

Dessen P

HNRNPM (heterogeneous nuclear ribonucleoprotein M)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50719/hnrnpm