HNRNPU (heterogeneous nuclear ribonucleoprotein U)

2007-07-01  

Identity

HGNC
LOCATION
1q44
LOCUSID
ALIAS
DEE54,EIEE54,GRIP120,HNRNPU-AS1,HNRPU,SAF-A,SAFA,U21.1,hnRNP

Other Information

Locus ID:

NCBI: 3192
MIM: 602869
HGNC: 5048
Ensembl: ENSG00000153187

Variants:

dbSNP: 3192
ClinVar: 3192
TCGA: ENSG00000153187
COSMIC: HNRNPU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153187ENST00000283179A0A1X7SBS1
ENSG00000153187ENST00000440865Q5RI18
ENSG00000153187ENST00000444376Q00839
ENSG00000153187ENST00000475997A0A087WZF3
ENSG00000153187ENST00000483966A0A1W2PRZ7
ENSG00000153187ENST00000489705A0A087WVI9
ENSG00000153187ENST00000638230A0A1W2PQL0
ENSG00000153187ENST00000638301A0A1W2PQ74
ENSG00000153187ENST00000638475A0A1W2PP35
ENSG00000153187ENST00000638716A0A1W2PPL4
ENSG00000153187ENST00000639628A0A1W2PPH7
ENSG00000153187ENST00000639824A0A1W2PQD4
ENSG00000153187ENST00000639880A0A1W2PNG3
ENSG00000153187ENST00000640001A0A1W2PP34
ENSG00000153187ENST00000640056A0A1W2PRI6
ENSG00000153187ENST00000640119A0A1W2PPE9
ENSG00000153187ENST00000640218Q00839
ENSG00000153187ENST00000640306A0A1W2PPS1
ENSG00000153187ENST00000640440A0A1W2PP22

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379232502024Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties.1
379847242024RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor.3
383692772024RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator.0
384008862024Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression.0
379232502024Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties.1
379847242024RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor.3
383692772024RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator.0
384008862024Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression.0
373320452023piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.7
374077332023Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome.6
378150902023Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis.1
379938812023circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression.4
382794972023ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells.0
373320452023piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.7
374077332023Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome.6

Citation

Dessen P

HNRNPU (heterogeneous nuclear ribonucleoprotein U)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47660/hnrnpu