HNRNPU (heterogeneous nuclear ribonucleoprotein U)

2007-07-01 Affiliation

Identity

HGNC

HNRNPU

LOCATION

1q44

LOCUSID

3192

ALIAS

DEE54,EIEE54,GRIP120,HNRNPU-AS1,HNRPU,SAF-A,SAFA,U21.1,hnRNP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3192
MIM: 602869
HGNC: 5048
Ensembl: ENSG00000153187

Variants:

dbSNP: 3192
ClinVar: 3192
TCGA: ENSG00000153187
COSMIC: HNRNPU

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000153187	ENST00000283179	A0A1X7SBS1
ENSG00000153187	ENST00000440865	Q5RI18
ENSG00000153187	ENST00000444376	Q00839
ENSG00000153187	ENST00000475997	A0A087WZF3
ENSG00000153187	ENST00000483966	A0A1W2PRZ7
ENSG00000153187	ENST00000489705	A0A087WVI9
ENSG00000153187	ENST00000638230	A0A1W2PQL0
ENSG00000153187	ENST00000638301	A0A1W2PQ74
ENSG00000153187	ENST00000638475	A0A1W2PP35
ENSG00000153187	ENST00000638716	A0A1W2PPL4
ENSG00000153187	ENST00000639628	A0A1W2PPH7
ENSG00000153187	ENST00000639824	A0A1W2PQD4
ENSG00000153187	ENST00000639880	A0A1W2PNG3
ENSG00000153187	ENST00000640001	A0A1W2PP34
ENSG00000153187	ENST00000640056	A0A1W2PRI6
ENSG00000153187	ENST00000640119	A0A1W2PPE9
ENSG00000153187	ENST00000640218	Q00839
ENSG00000153187	ENST00000640306	A0A1W2PPS1
ENSG00000153187	ENST00000640440	A0A1W2PP22

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22810585	2012	Viral immune modulators perturb the human molecular network by common and unique strategies.	109
19165527	2009	Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.	56
18710935	2008	The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription.	55
22325991	2012	Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.	45
20150277	2010	The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.	42
11850407	2002	Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U.	40
11909954	2002	Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.	26
20382278	2010	Four patients with speech delay, seizures and variable corpus callosum thickness sharing a 0.440 Mb deletion in region 1q44 containing the HNRPU gene.	26
22902625	2012	Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction.	26
23396972	2013	hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.	25

Citation

Dessen P

HNRNPU (heterogeneous nuclear ribonucleoprotein U)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47660/hnrnpu