Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HNRNPU (heterogeneous nuclear ribonucleoprotein U)

Identity

Alias_namesHNRPU
HNRNPU-AS1
C1orf199
NCRNA00201
HNRNPU antisense RNA 1
chromosome 1 open reading frame 199
non-protein coding RNA 201
HNRNPU antisense RNA 1 (non-protein coding)
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
Alias_symbol (synonym)SAF-A
hnRNPU
FLJ37978
FLJ30202
Other aliasEIEE54
GRIP120
SAFA
U21.1
hnRNP U
pp120
HGNC (Hugo) HNRNPU
LocusID (NCBI) 3192
Atlas_Id 47660
Location 1q44  [Link to chromosome band 1q44]
Location_base_pair Starts at 244850300 and ends at 244864525 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HNRNPU (1q44) / C8orf34 (8q13.2)HNRNPU (1q44) / EMG1 (12p13.31)HNRNPU (1q44) / HNRNPU (1q44)
HNRNPU (1q44) / RPL24 (3q12.3)HNRNPU (1q44) / SNRNP25 (16p13.3)HNRNPU (1q44) / VPS39 (15q15.1)
HNRNPU (1q44) / YWHAE (17p13.3)MTND2P28 (5q11.2) / HNRNPU (1q44)PCNT (21q22.3) / HNRNPU (1q44)
TES (7q31.2) / HNRNPU (1q44)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;7)(q44;q31) TES/HNRNPU


External links

Nomenclature
HGNC (Hugo)HNRNPU   5048
Cards
Entrez_Gene (NCBI)HNRNPU  3192  heterogeneous nuclear ribonucleoprotein U
AliasesEIEE54; GRIP120; HNRNPU-AS1; HNRPU; 
SAF-A; SAFA; U21.1; hnRNP; pp120
GeneCards (Weizmann)HNRNPU
Ensembl hg19 (Hinxton)ENSG00000153187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153187 [Gene_View]  ENSG00000153187 [Sequence]  chr1:244850300-244864525 [Contig_View]  HNRNPU [Vega]
ICGC DataPortalENSG00000153187
TCGA cBioPortalHNRNPU
AceView (NCBI)HNRNPU
Genatlas (Paris)HNRNPU
WikiGenes3192
SOURCE (Princeton)HNRNPU
Genetics Home Reference (NIH)HNRNPU
Genomic and cartography
GoldenPath hg38 (UCSC)HNRNPU  -     chr1:244850300-244864525 -  1q44   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HNRNPU  -     1q44   [Description]    (hg19-Feb_2009)
EnsemblHNRNPU - 1q44 [CytoView hg19]  HNRNPU - 1q44 [CytoView hg38]
Mapping of homologs : NCBIHNRNPU [Mapview hg19]  HNRNPU [Mapview hg38]
OMIM602869   617391   
Gene and transcription
Genbank (Entrez)AA773071 AF068846 AF448858 AF461014 AK054764
RefSeq transcript (Entrez)NM_004501 NM_031844
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HNRNPU
Cluster EST : UnigeneHs.743421 [ NCBI ]
CGAP (NCI)Hs.743421
Alternative Splicing GalleryENSG00000153187
Gene ExpressionHNRNPU [ NCBI-GEO ]   HNRNPU [ EBI - ARRAY_EXPRESS ]   HNRNPU [ SEEK ]   HNRNPU [ MEM ]
Gene Expression Viewer (FireBrowse)HNRNPU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3192
GTEX Portal (Tissue expression)HNRNPU
Human Protein AtlasENSG00000153187-HNRNPU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00839   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00839  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00839
Splice isoforms : SwissVarQ00839
PhosPhoSitePlusQ00839
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    SAP (PS50800)   
Domains : Interpro (EBI)B30.2/SPRY    ConA-like_dom    hnRNP_U    P-loop_NTPase    SAP_dom    SPRY_dom   
Domain families : Pfam (Sanger)SAP (PF02037)    SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam02037    pfam00622   
Domain families : Smart (EMBL)SAP (SM00513)  SPRY (SM00449)  
Conserved Domain (NCBI)HNRNPU
DMDM Disease mutations3192
Blocks (Seattle)HNRNPU
PDB (SRS)1ZRJ   
PDB (PDBSum)1ZRJ   
PDB (IMB)1ZRJ   
PDB (RSDB)1ZRJ   
Structural Biology KnowledgeBase1ZRJ   
SCOP (Structural Classification of Proteins)1ZRJ   
CATH (Classification of proteins structures)1ZRJ   
SuperfamilyQ00839
Human Protein Atlas [tissue]ENSG00000153187-HNRNPU [tissue]
Peptide AtlasQ00839
HPRD04185
IPIIPI00883857   IPI00479217   IPI00644079   IPI00644224   
Protein Interaction databases
DIP (DOE-UCLA)Q00839
IntAct (EBI)Q00839
FunCoupENSG00000153187
BioGRIDHNRNPU
STRING (EMBL)HNRNPU
ZODIACHNRNPU
Ontologies - Pathways
QuickGOQ00839
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  kinetochore  condensed chromosome kinetochore  spindle pole  RNA polymerase II core binding  core promoter binding  TFIIH-class transcription factor binding  osteoblast differentiation  DNA binding  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  transcription corepressor activity  RNA binding  RNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  mRNA 3'-UTR binding  actin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  centrosome  transcription, DNA-templated  RNA processing  cell cycle  regulation of mitotic cell cycle  poly(A) binding  dosage compensation by inactivation of X chromosome  cell surface  membrane  RNA metabolic process  nuclear matrix  covalent chromatin modification  nuclear speck  snRNA binding  poly(C) RNA binding  midbody  intracellular ribonucleoprotein complex  extracellular matrix  chromatin DNA binding  negative regulation of telomere maintenance via telomerase  circadian regulation of gene expression  macromolecular complex  negative regulation of kinase activity  poly(G) binding  negative regulation of transcription elongation from RNA polymerase II promoter  pre-mRNA binding  cytoplasmic ribonucleoprotein granule  identical protein binding  ribonucleoprotein complex binding  macromolecular complex binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  mRNA stabilization  cell division  maintenance of protein location in nucleus  cardiac muscle cell development  telomerase RNA binding  CRD-mediated mRNA stabilization  CRD-mediated mRNA stability complex  catalytic step 2 spliceosome  cellular response to glucocorticoid stimulus  mitotic spindle  RNA polymerase II transcription factor complex  inactive sex chromosome  RNA polymerase II C-terminal domain binding  regulation of mitotic spindle assembly  regulation of chromatin organization  positive regulation of attachment of mitotic spindle microtubules to kinetochore  protein localization to spindle microtubule  mitotic spindle midzone  RNA localization to chromatin  mitotic spindle microtubule  cellular response to leukemia inhibitory factor  sequence-specific double-stranded DNA binding  promoter-specific chromatin binding  ribonucleoprotein complex  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  positive regulation of stem cell proliferation  negative regulation of stem cell differentiation  negative regulation of stem cell differentiation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  kinetochore  condensed chromosome kinetochore  spindle pole  RNA polymerase II core binding  core promoter binding  TFIIH-class transcription factor binding  osteoblast differentiation  DNA binding  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  transcription corepressor activity  RNA binding  RNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  mRNA 3'-UTR binding  actin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  centrosome  transcription, DNA-templated  RNA processing  cell cycle  regulation of mitotic cell cycle  poly(A) binding  dosage compensation by inactivation of X chromosome  cell surface  membrane  RNA metabolic process  nuclear matrix  covalent chromatin modification  nuclear speck  snRNA binding  poly(C) RNA binding  midbody  intracellular ribonucleoprotein complex  extracellular matrix  chromatin DNA binding  negative regulation of telomere maintenance via telomerase  circadian regulation of gene expression  macromolecular complex  negative regulation of kinase activity  poly(G) binding  negative regulation of transcription elongation from RNA polymerase II promoter  pre-mRNA binding  cytoplasmic ribonucleoprotein granule  identical protein binding  ribonucleoprotein complex binding  macromolecular complex binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  mRNA stabilization  cell division  maintenance of protein location in nucleus  cardiac muscle cell development  telomerase RNA binding  CRD-mediated mRNA stabilization  CRD-mediated mRNA stability complex  catalytic step 2 spliceosome  cellular response to glucocorticoid stimulus  mitotic spindle  RNA polymerase II transcription factor complex  inactive sex chromosome  RNA polymerase II C-terminal domain binding  regulation of mitotic spindle assembly  regulation of chromatin organization  positive regulation of attachment of mitotic spindle microtubules to kinetochore  protein localization to spindle microtubule  mitotic spindle midzone  RNA localization to chromatin  mitotic spindle microtubule  cellular response to leukemia inhibitory factor  sequence-specific double-stranded DNA binding  promoter-specific chromatin binding  ribonucleoprotein complex  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  positive regulation of stem cell proliferation  negative regulation of stem cell differentiation  negative regulation of stem cell differentiation  
NDEx NetworkHNRNPU
Atlas of Cancer Signalling NetworkHNRNPU
Wikipedia pathwaysHNRNPU
Orthology - Evolution
OrthoDB3192
GeneTree (enSembl)ENSG00000153187
Phylogenetic Trees/Animal Genes : TreeFamHNRNPU
HOVERGENQ00839
HOGENOMQ00839
Homologs : HomoloGeneHNRNPU
Homology/Alignments : Family Browser (UCSC)HNRNPU
Gene fusions - Rearrangements
Fusion : MitelmanTES/HNRNPU [7q31.2/1q44]  [t(1;7)(q44;q31)]  
Fusion Cancer (Beijing)MTND2P28 [5q11.2]  -  HNRNPU [1q44]  [FUSC000973]
Fusion : QuiverHNRNPU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHNRNPU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HNRNPU
dbVarHNRNPU
ClinVarHNRNPU
1000_GenomesHNRNPU 
Exome Variant ServerHNRNPU
ExAC (Exome Aggregation Consortium)ENSG00000153187
GNOMAD BrowserENSG00000153187
Genetic variants : HAPMAP3192
Genomic Variants (DGV)HNRNPU [DGVbeta]
DECIPHERHNRNPU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHNRNPU 
Mutations
ICGC Data PortalHNRNPU 
TCGA Data PortalHNRNPU 
Broad Tumor PortalHNRNPU
OASIS PortalHNRNPU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHNRNPU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHNRNPU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HNRNPU
DgiDB (Drug Gene Interaction Database)HNRNPU
DoCM (Curated mutations)HNRNPU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HNRNPU (select a term)
intoGenHNRNPU
Cancer3DHNRNPU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602869    617391   
Orphanet
DisGeNETHNRNPU
MedgenHNRNPU
Genetic Testing Registry HNRNPU
NextProtQ00839 [Medical]
TSGene3192
GENETestsHNRNPU
Target ValidationHNRNPU
Huge Navigator HNRNPU [HugePedia]
snp3D : Map Gene to Disease3192
BioCentury BCIQHNRNPU
ClinGenHNRNPU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3192
Chemical/Pharm GKB GenePA162391486
Clinical trialHNRNPU
Miscellaneous
canSAR (ICR)HNRNPU (select the gene name)
Probes
Litterature
PubMed209 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHNRNPU
EVEXHNRNPU
GoPubMedHNRNPU
iHOPHNRNPU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:29:27 CEST 2018

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