Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HNRNPU (heterogeneous nuclear ribonucleoprotein U)

Identity

Alias (NCBI)DEE54
EIEE54
GRIP120
HNRNPU-AS1
HNRPU
SAF-A
SAFA
U21.1
hnRNP U
pp120
HGNC (Hugo) HNRNPU
HGNC Alias symbSAF-A
FLJ37978
FLJ30202
HGNC Alias namescaffold attachment factor A
HGNC Previous nameHNRPU
 HNRNPU-AS1
 C1orf199
 NCRNA00201
HGNC Previous nameHNRNPU antisense RNA 1
 chromosome 1 open reading frame 199
 non-protein coding RNA 201
 HNRNPU antisense RNA 1 (non-protein coding)
 heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
LocusID (NCBI) 3192
Atlas_Id 47660
Location 1q44  [Link to chromosome band 1q44]
Location_base_pair Starts at 244850297 and ends at 244864543 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HNRNPU (1q44) / C8orf34 (8q13.2)HNRNPU (1q44) / EMG1 (12p13.31)HNRNPU (1q44) / HNRNPU (1q44)
HNRNPU (1q44) / RPL24 (3q12.3)HNRNPU (1q44) / SNRNP25 (16p13.3)HNRNPU (1q44) / VPS39 (15q15.1)
HNRNPU (1q44) / YWHAE (17p13.3)MTND2P28 (5q11.2) / HNRNPU (1q44)PCNT (21q22.3) / HNRNPU (1q44)
TES (7q31.2) / HNRNPU (1q44)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HNRNPU   5048
Cards
Entrez_Gene (NCBI)HNRNPU    heterogeneous nuclear ribonucleoprotein U
AliasesDEE54; EIEE54; GRIP120; HNRNPU-AS1; 
HNRPU; SAF-A; SAFA; U21.1; hnRNP; pp120
GeneCards (Weizmann)HNRNPU
Ensembl hg19 (Hinxton)ENSG00000153187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153187 [Gene_View]  ENSG00000153187 [Sequence]  chr1:244850297-244864543 [Contig_View]  HNRNPU [Vega]
ICGC DataPortalENSG00000153187
TCGA cBioPortalHNRNPU
AceView (NCBI)HNRNPU
Genatlas (Paris)HNRNPU
SOURCE (Princeton)HNRNPU
Genetics Home Reference (NIH)HNRNPU
Genomic and cartography
GoldenPath hg38 (UCSC)HNRNPU  -     chr1:244850297-244864543 -  1q44   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HNRNPU  -     1q44   [Description]    (hg19-Feb_2009)
GoldenPathHNRNPU - 1q44 [CytoView hg19]  HNRNPU - 1q44 [CytoView hg38]
ImmunoBaseENSG00000153187
Genome Data Viewer NCBIHNRNPU [Mapview hg19]  
OMIM602869   617391   
Gene and transcription
Genbank (Entrez)AA773071 AF068846 AF448858 AF461014 AK054764
RefSeq transcript (Entrez)NM_004501 NM_031844
Consensus coding sequences : CCDS (NCBI)HNRNPU
Gene ExpressionHNRNPU [ NCBI-GEO ]   HNRNPU [ EBI - ARRAY_EXPRESS ]   HNRNPU [ SEEK ]   HNRNPU [ MEM ]
Gene Expression Viewer (FireBrowse)HNRNPU [ Firebrowse - Broad ]
GenevisibleExpression of HNRNPU in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3192
GTEX Portal (Tissue expression)HNRNPU
Human Protein AtlasENSG00000153187-HNRNPU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00839   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00839  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00839
PhosPhoSitePlusQ00839
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    SAP (PS50800)   
Domains : Interpro (EBI)B30.2/SPRY    B30.2/SPRY_sf    ConA-like_dom_sf    hnRNP_U    P-loop_NTPase    SAP_dom    SAP_dom_sf    SPRY_dom    SPRY_hnRNP_U   
Domain families : Pfam (Sanger)SAP (PF02037)    SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam02037    pfam00622   
Domain families : Smart (EMBL)SAP (SM00513)  SPRY (SM00449)  
Conserved Domain (NCBI)HNRNPU
PDB (RSDB)1ZRJ   
PDB Europe1ZRJ   
PDB (PDBSum)1ZRJ   
PDB (IMB)1ZRJ   
Structural Biology KnowledgeBase1ZRJ   
SCOP (Structural Classification of Proteins)1ZRJ   
CATH (Classification of proteins structures)1ZRJ   
SuperfamilyQ00839
AlphaFold pdb e-kbQ00839   
Human Protein Atlas [tissue]ENSG00000153187-HNRNPU [tissue]
HPRD04185
Protein Interaction databases
DIP (DOE-UCLA)Q00839
IntAct (EBI)Q00839
BioGRIDHNRNPU
STRING (EMBL)HNRNPU
ZODIACHNRNPU
Ontologies - Pathways
QuickGOQ00839
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromosome  nuclear chromosome  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  kinetochore  kinetochore  spindle pole  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II complex binding  TFIIH-class transcription factor complex binding  TFIIH-class transcription factor complex binding  osteoblast differentiation  DNA binding  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  transcription corepressor activity  transcription corepressor activity  RNA binding  RNA binding  RNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  mRNA 3'-UTR binding  actin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  telomerase holoenzyme complex  centrosome  centrosome  chromatin organization  RNA processing  cell cycle  regulation of mitotic cell cycle  poly(A) binding  dosage compensation by inactivation of X chromosome  cell surface  membrane  RNA metabolic process  nuclear matrix  nuclear matrix  nuclear speck  nuclear speck  snRNA binding  snRNA binding  poly(C) RNA binding  poly(C) RNA binding  midbody  chromatin DNA binding  negative regulation of telomere maintenance via telomerase  negative regulation of telomere maintenance via telomerase  dendrite cytoplasm  circadian regulation of gene expression  protein-containing complex  negative regulation of kinase activity  poly(G) binding  poly(G) binding  negative regulation of transcription elongation from RNA polymerase II promoter  pre-mRNA binding  pre-mRNA binding  cytoplasmic ribonucleoprotein granule  cytoplasmic ribonucleoprotein granule  identical protein binding  ribonucleoprotein complex binding  ribonucleoprotein complex binding  protein-containing complex binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  mRNA stabilization  cell division  maintenance of protein location in nucleus  cardiac muscle cell development  telomerase RNA binding  CRD-mediated mRNA stabilization  CRD-mediated mRNA stabilization  CRD-mediated mRNA stability complex  CRD-mediated mRNA stability complex  catalytic step 2 spliceosome  catalytic step 2 spliceosome  cellular response to glucocorticoid stimulus  mitotic spindle  positive regulation of brown fat cell differentiation  inactive sex chromosome  inactive sex chromosome  dendritic transport of messenger ribonucleoprotein complex  RNA polymerase II C-terminal domain binding  RNA polymerase II C-terminal domain binding  regulation of mitotic spindle assembly  regulation of mitotic spindle assembly  regulation of chromatin organization  regulation of chromatin organization  positive regulation of attachment of mitotic spindle microtubules to kinetochore  positive regulation of attachment of mitotic spindle microtubules to kinetochore  protein localization to spindle microtubule  mitotic spindle midzone  mitotic spindle midzone  RNA localization to chromatin  RNA localization to chromatin  mitotic spindle microtubule  mitotic spindle microtubule  cellular response to leukemia inhibitory factor  sequence-specific double-stranded DNA binding  promoter-specific chromatin binding  promoter-specific chromatin binding  adaptive thermogenesis  ribonucleoprotein complex  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  positive regulation of stem cell proliferation  negative regulation of stem cell differentiation  negative regulation of stem cell differentiation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromosome  nuclear chromosome  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  kinetochore  kinetochore  spindle pole  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II complex binding  TFIIH-class transcription factor complex binding  TFIIH-class transcription factor complex binding  osteoblast differentiation  DNA binding  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  transcription corepressor activity  transcription corepressor activity  RNA binding  RNA binding  RNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  mRNA 3'-UTR binding  actin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  telomerase holoenzyme complex  centrosome  centrosome  chromatin organization  RNA processing  cell cycle  regulation of mitotic cell cycle  poly(A) binding  dosage compensation by inactivation of X chromosome  cell surface  membrane  RNA metabolic process  nuclear matrix  nuclear matrix  nuclear speck  nuclear speck  snRNA binding  snRNA binding  poly(C) RNA binding  poly(C) RNA binding  midbody  chromatin DNA binding  negative regulation of telomere maintenance via telomerase  negative regulation of telomere maintenance via telomerase  dendrite cytoplasm  circadian regulation of gene expression  protein-containing complex  negative regulation of kinase activity  poly(G) binding  poly(G) binding  negative regulation of transcription elongation from RNA polymerase II promoter  pre-mRNA binding  pre-mRNA binding  cytoplasmic ribonucleoprotein granule  cytoplasmic ribonucleoprotein granule  identical protein binding  ribonucleoprotein complex binding  ribonucleoprotein complex binding  protein-containing complex binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  mRNA stabilization  cell division  maintenance of protein location in nucleus  cardiac muscle cell development  telomerase RNA binding  CRD-mediated mRNA stabilization  CRD-mediated mRNA stabilization  CRD-mediated mRNA stability complex  CRD-mediated mRNA stability complex  catalytic step 2 spliceosome  catalytic step 2 spliceosome  cellular response to glucocorticoid stimulus  mitotic spindle  positive regulation of brown fat cell differentiation  inactive sex chromosome  inactive sex chromosome  dendritic transport of messenger ribonucleoprotein complex  RNA polymerase II C-terminal domain binding  RNA polymerase II C-terminal domain binding  regulation of mitotic spindle assembly  regulation of mitotic spindle assembly  regulation of chromatin organization  regulation of chromatin organization  positive regulation of attachment of mitotic spindle microtubules to kinetochore  positive regulation of attachment of mitotic spindle microtubules to kinetochore  protein localization to spindle microtubule  mitotic spindle midzone  mitotic spindle midzone  RNA localization to chromatin  RNA localization to chromatin  mitotic spindle microtubule  mitotic spindle microtubule  cellular response to leukemia inhibitory factor  sequence-specific double-stranded DNA binding  promoter-specific chromatin binding  promoter-specific chromatin binding  adaptive thermogenesis  ribonucleoprotein complex  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  positive regulation of stem cell proliferation  negative regulation of stem cell differentiation  negative regulation of stem cell differentiation  
Pathways : KEGGSpliceosome   
NDEx NetworkHNRNPU
Atlas of Cancer Signalling NetworkHNRNPU
Wikipedia pathwaysHNRNPU
Orthology - Evolution
OrthoDB3192
GeneTree (enSembl)ENSG00000153187
Phylogenetic Trees/Animal Genes : TreeFamHNRNPU
Homologs : HomoloGeneHNRNPU
Homology/Alignments : Family Browser (UCSC)HNRNPU
Gene fusions - Rearrangements
Fusion : MitelmanTES/HNRNPU [7q31.2/1q44]  
Fusion Cancer (Beijing)MTND2P28 [5q11.2]  -  HNRNPU [1q44]  [FUSC000973]
Fusion : QuiverHNRNPU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHNRNPU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HNRNPU
dbVarHNRNPU
ClinVarHNRNPU
MonarchHNRNPU
1000_GenomesHNRNPU 
Exome Variant ServerHNRNPU
GNOMAD BrowserENSG00000153187
Varsome BrowserHNRNPU
ACMGHNRNPU variants
VarityQ00839
Genomic Variants (DGV)HNRNPU [DGVbeta]
DECIPHERHNRNPU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHNRNPU 
Mutations
ICGC Data PortalHNRNPU 
TCGA Data PortalHNRNPU 
Broad Tumor PortalHNRNPU
OASIS PortalHNRNPU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHNRNPU  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHNRNPU
Mutations and Diseases : HGMDHNRNPU
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHNRNPU
DgiDB (Drug Gene Interaction Database)HNRNPU
DoCM (Curated mutations)HNRNPU
CIViC (Clinical Interpretations of Variants in Cancer)HNRNPU
Cancer3DHNRNPU
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602869    617391   
Orphanet
DisGeNETHNRNPU
MedgenHNRNPU
Genetic Testing Registry HNRNPU
NextProtQ00839 [Medical]
GENETestsHNRNPU
Target ValidationHNRNPU
Huge Navigator HNRNPU [HugePedia]
ClinGenHNRNPU
Clinical trials, drugs, therapy
MyCancerGenomeHNRNPU
Protein Interactions : CTDHNRNPU
Pharm GKB GenePA162391486
PharosQ00839
Clinical trialHNRNPU
Miscellaneous
canSAR (ICR)HNRNPU
HarmonizomeHNRNPU
DataMed IndexHNRNPU
Probes
Litterature
PubMed319 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHNRNPU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:42 CEST 2021

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