Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1)

Identity

Alias (NCBI)C10orf65
DHDPS2
DHDPSL
HP3
NPL2
HGNC (Hugo) HOGA1
HGNC Alias symbFLJ37472
DHDPS2
NPL2
HGNC Alias namedihydrodipicolinate synthetase homolog 2 (E. coli)
 N-acetylneuraminate pyruvate lyase 2 (putative)
HGNC Previous nameC10orf65
 DHDPSL
HGNC Previous namechromosome 10 open reading frame 65
 dihydrodipicolinate synthase-like, mitochondrial
LocusID (NCBI) 112817
Atlas_Id 64378
Location 10q24.2  [Link to chromosome band 10q24]
Location_base_pair Starts at 97584389 and ends at 97612798 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOGA1 (10q24.2) / LOC100507412 (-)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HOGA1   25155
Cards
Entrez_Gene (NCBI)HOGA1    4-hydroxy-2-oxoglutarate aldolase 1
AliasesC10orf65; DHDPS2; DHDPSL; HP3; 
NPL2
GeneCards (Weizmann)HOGA1
Ensembl hg19 (Hinxton)ENSG00000241935 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000241935 [Gene_View]  ENSG00000241935 [Sequence]  chr10:97584389-97612798 [Contig_View]  HOGA1 [Vega]
ICGC DataPortalENSG00000241935
TCGA cBioPortalHOGA1
AceView (NCBI)HOGA1
Genatlas (Paris)HOGA1
SOURCE (Princeton)HOGA1
Genetics Home Reference (NIH)HOGA1
Genomic and cartography
GoldenPath hg38 (UCSC)HOGA1  -     chr10:97584389-97612798 +  10q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOGA1  -     10q24.2   [Description]    (hg19-Feb_2009)
GoldenPathHOGA1 - 10q24.2 [CytoView hg19]  HOGA1 - 10q24.2 [CytoView hg38]
ImmunoBaseENSG00000241935
Genome Data Viewer NCBIHOGA1 [Mapview hg19]  
OMIM613597   613616   
Gene and transcription
Genbank (Entrez)AK094791 AK289440 BC011916 BC045550 BC057821
RefSeq transcript (Entrez)NM_001134670 NM_138413
Consensus coding sequences : CCDS (NCBI)HOGA1
Gene ExpressionHOGA1 [ NCBI-GEO ]   HOGA1 [ EBI - ARRAY_EXPRESS ]   HOGA1 [ SEEK ]   HOGA1 [ MEM ]
Gene Expression Viewer (FireBrowse)HOGA1 [ Firebrowse - Broad ]
GenevisibleExpression of HOGA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112817
GTEX Portal (Tissue expression)HOGA1
Human Protein AtlasENSG00000241935-HOGA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XE5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XE5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XE5
Catalytic activity : Enzyme4.1.3.16 [ Enzyme-Expasy ]   4.1.3.164.1.3.16 [ IntEnz-EBI ]   4.1.3.16 [ BRENDA ]   4.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ86XE5
Domaine pattern : Prosite (Expaxy)DHDPS_2 (PS00666)   
Domains : Interpro (EBI)Aldolase_TIM    DapA-like    Schiff_base-form_aldolases_AS   
Domain families : Pfam (Sanger)DHDPS (PF00701)   
Domain families : Pfam (NCBI)pfam00701   
Domain families : Smart (EMBL)DHDPS (SM01130)  
Conserved Domain (NCBI)HOGA1
PDB (RSDB)3S5N    3S5O   
PDB Europe3S5N    3S5O   
PDB (PDBSum)3S5N    3S5O   
PDB (IMB)3S5N    3S5O   
Structural Biology KnowledgeBase3S5N    3S5O   
SCOP (Structural Classification of Proteins)3S5N    3S5O   
CATH (Classification of proteins structures)3S5N    3S5O   
SuperfamilyQ86XE5
AlphaFold pdb e-kbQ86XE5   
Human Protein Atlas [tissue]ENSG00000241935-HOGA1 [tissue]
HPRD12584
Protein Interaction databases
DIP (DOE-UCLA)Q86XE5
IntAct (EBI)Q86XE5
BioGRIDHOGA1
STRING (EMBL)HOGA1
ZODIACHOGA1
Ontologies - Pathways
QuickGOQ86XE5
Ontology : AmiGOprotein binding  mitochondrion  mitochondrial matrix  4-hydroxy-2-oxoglutarate aldolase activity  4-hydroxy-2-oxoglutarate aldolase activity  glyoxylate catabolic process  4-hydroxyproline catabolic process  oxalate metabolic process  protein homodimerization activity  pyruvate biosynthetic process  glyoxylate metabolic process  glyoxylate metabolic process  
Ontology : EGO-EBIprotein binding  mitochondrion  mitochondrial matrix  4-hydroxy-2-oxoglutarate aldolase activity  4-hydroxy-2-oxoglutarate aldolase activity  glyoxylate catabolic process  4-hydroxyproline catabolic process  oxalate metabolic process  protein homodimerization activity  pyruvate biosynthetic process  glyoxylate metabolic process  glyoxylate metabolic process  
NDEx NetworkHOGA1
Atlas of Cancer Signalling NetworkHOGA1
Wikipedia pathwaysHOGA1
Orthology - Evolution
OrthoDB112817
GeneTree (enSembl)ENSG00000241935
Phylogenetic Trees/Animal Genes : TreeFamHOGA1
Homologs : HomoloGeneHOGA1
Homology/Alignments : Family Browser (UCSC)HOGA1
Gene fusions - Rearrangements
Fusion : QuiverHOGA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOGA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOGA1
dbVarHOGA1
ClinVarHOGA1
MonarchHOGA1
1000_GenomesHOGA1 
Exome Variant ServerHOGA1
GNOMAD BrowserENSG00000241935
Varsome BrowserHOGA1
ACMGHOGA1 variants
VarityQ86XE5
Genomic Variants (DGV)HOGA1 [DGVbeta]
DECIPHERHOGA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOGA1 
Mutations
ICGC Data PortalHOGA1 
TCGA Data PortalHOGA1 
Broad Tumor PortalHOGA1
OASIS PortalHOGA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOGA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHOGA1
Mutations and Diseases : HGMDHOGA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHOGA1
DgiDB (Drug Gene Interaction Database)HOGA1
DoCM (Curated mutations)HOGA1
CIViC (Clinical Interpretations of Variants in Cancer)HOGA1
Cancer3DHOGA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613597    613616   
Orphanet12433   
DisGeNETHOGA1
MedgenHOGA1
Genetic Testing Registry HOGA1
NextProtQ86XE5 [Medical]
GENETestsHOGA1
Target ValidationHOGA1
Huge Navigator HOGA1 [HugePedia]
ClinGenHOGA1
Clinical trials, drugs, therapy
MyCancerGenomeHOGA1
Protein Interactions : CTDHOGA1
Pharm GKB GenePA165548441
PharosQ86XE5
Clinical trialHOGA1
Miscellaneous
canSAR (ICR)HOGA1
HarmonizomeHOGA1
DataMed IndexHOGA1
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHOGA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:53:05 CEST 2021

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