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HOOK1 (hook microtubule tethering protein 1)

Identity

Alias_nameshook homolog 1 (Drosophila)
Alias_symbol (synonym)HK1
Other alias
HGNC (Hugo) HOOK1
LocusID (NCBI) 51361
Atlas_Id 56325
Location 1p32.1  [Link to chromosome band 1p32]
Location_base_pair Starts at 59814861 and ends at 59876378 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAF1 (1p32.3) / HOOK1 (1p32.1)HOOK1 (1p32.1) / HOOK1 (1p32.1)MTL5 (11q13.3) / HOOK1 (1p32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Kidney: ALK-rearranged renal cell carcinoma


External links

Nomenclature
HGNC (Hugo)HOOK1   19884
Cards
Entrez_Gene (NCBI)HOOK1  51361  hook microtubule tethering protein 1
AliasesHK1
GeneCards (Weizmann)HOOK1
Ensembl hg19 (Hinxton)ENSG00000134709 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134709 [Gene_View]  chr1:59814861-59876378 [Contig_View]  HOOK1 [Vega]
ICGC DataPortalENSG00000134709
TCGA cBioPortalHOOK1
AceView (NCBI)HOOK1
Genatlas (Paris)HOOK1
WikiGenes51361
SOURCE (Princeton)HOOK1
Genetics Home Reference (NIH)HOOK1
Genomic and cartography
GoldenPath hg38 (UCSC)HOOK1  -     chr1:59814861-59876378 +  1p32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOOK1  -     1p32.1   [Description]    (hg19-Feb_2009)
EnsemblHOOK1 - 1p32.1 [CytoView hg19]  HOOK1 - 1p32.1 [CytoView hg38]
Mapping of homologs : NCBIHOOK1 [Mapview hg19]  HOOK1 [Mapview hg38]
OMIM607820   
Gene and transcription
Genbank (Entrez)AA576610 AF044923 AK027250 AK097735 AK098561
RefSeq transcript (Entrez)NM_015888
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOOK1
Cluster EST : UnigeneHs.378836 [ NCBI ]
CGAP (NCI)Hs.378836
Alternative Splicing GalleryENSG00000134709
Gene ExpressionHOOK1 [ NCBI-GEO ]   HOOK1 [ EBI - ARRAY_EXPRESS ]   HOOK1 [ SEEK ]   HOOK1 [ MEM ]
Gene Expression Viewer (FireBrowse)HOOK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51361
GTEX Portal (Tissue expression)HOOK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJC3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJC3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJC3
Splice isoforms : SwissVarQ9UJC3
PhosPhoSitePlusQ9UJC3
Domains : Interpro (EBI)Hook-related_fam   
Domain families : Pfam (Sanger)HOOK (PF05622)   
Domain families : Pfam (NCBI)pfam05622   
Conserved Domain (NCBI)HOOK1
DMDM Disease mutations51361
Blocks (Seattle)HOOK1
SuperfamilyQ9UJC3
Human Protein AtlasENSG00000134709
Peptide AtlasQ9UJC3
HPRD07428
IPIIPI00026305   IPI00873551   IPI00646832   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJC3
IntAct (EBI)Q9UJC3
FunCoupENSG00000134709
BioGRIDHOOK1
STRING (EMBL)HOOK1
ZODIACHOOK1
Ontologies - Pathways
QuickGOQ9UJC3
Ontology : AmiGOactin binding  protein binding  centrosome  cytosol  microtubule  endosome organization  lysosome organization  multicellular organism development  spermatid development  microtubule binding  endosome to lysosome transport  protein transport  cytoskeleton-dependent intracellular transport  HOPS complex  cytoplasmic microtubule organization  identical protein binding  early endosome to late endosome transport  dynein light intermediate chain binding  FHF complex  
Ontology : EGO-EBIactin binding  protein binding  centrosome  cytosol  microtubule  endosome organization  lysosome organization  multicellular organism development  spermatid development  microtubule binding  endosome to lysosome transport  protein transport  cytoskeleton-dependent intracellular transport  HOPS complex  cytoplasmic microtubule organization  identical protein binding  early endosome to late endosome transport  dynein light intermediate chain binding  FHF complex  
NDEx NetworkHOOK1
Atlas of Cancer Signalling NetworkHOOK1
Wikipedia pathwaysHOOK1
Orthology - Evolution
OrthoDB51361
GeneTree (enSembl)ENSG00000134709
Phylogenetic Trees/Animal Genes : TreeFamHOOK1
HOVERGENQ9UJC3
HOGENOMQ9UJC3
Homologs : HomoloGeneHOOK1
Homology/Alignments : Family Browser (UCSC)HOOK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOOK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOOK1
dbVarHOOK1
ClinVarHOOK1
1000_GenomesHOOK1 
Exome Variant ServerHOOK1
ExAC (Exome Aggregation Consortium)HOOK1 (select the gene name)
Genetic variants : HAPMAP51361
Genomic Variants (DGV)HOOK1 [DGVbeta]
DECIPHERHOOK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOOK1 
Mutations
ICGC Data PortalHOOK1 
TCGA Data PortalHOOK1 
Broad Tumor PortalHOOK1
OASIS PortalHOOK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOOK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOOK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOOK1
DgiDB (Drug Gene Interaction Database)HOOK1
DoCM (Curated mutations)HOOK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOOK1 (select a term)
intoGenHOOK1
Cancer3DHOOK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607820   
Orphanet
MedgenHOOK1
Genetic Testing Registry HOOK1
NextProtQ9UJC3 [Medical]
TSGene51361
GENETestsHOOK1
Target ValidationHOOK1
Huge Navigator HOOK1 [HugePedia]
snp3D : Map Gene to Disease51361
BioCentury BCIQHOOK1
ClinGenHOOK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51361
Chemical/Pharm GKB GenePA134945565
Clinical trialHOOK1
Miscellaneous
canSAR (ICR)HOOK1 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOOK1
EVEXHOOK1
GoPubMedHOOK1
iHOPHOOK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:55:35 CEST 2017

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