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HOOK2 (hook microtubule tethering protein 2)

Identity

Alias (NCBI)HK2
HGNC (Hugo) HOOK2
HGNC Alias symbHK2
HGNC Previous namehook homolog 2 (Drosophila)
LocusID (NCBI) 29911
Atlas_Id 54366
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12763003 and ends at 12775552 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK2AP2 (11q13.2) / HOOK2 (19p13.2)HOOK2 (19p13.2) / ACTN3 (11q13.2)HOOK2 (19p13.2) / CPAMD8 (19p13.11)
HOOK2 (19p13.2) / MAST1 (19p13.2)HOOK2 (19p13.2) / RTBDN (19p13.2)LUC7L (16p13.3) / HOOK2 (19p13.2)
HOOK2 19p13.2 / MAST1 19p13.2HOOK2 19p13.2 / RTBDN 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;19)(q13;p13) HOOK2/ACTN3
HOOK2/MAST1 (19p13)
HOOK2/RTBDN (19p13)

External links

Nomenclature
HGNC (Hugo)HOOK2   19885
Cards
Entrez_Gene (NCBI)HOOK2    hook microtubule tethering protein 2
AliasesHK2
GeneCards (Weizmann)HOOK2
Ensembl hg19 (Hinxton)ENSG00000095066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095066 [Gene_View]  ENSG00000095066 [Sequence]  chr19:12763003-12775552 [Contig_View]  HOOK2 [Vega]
ICGC DataPortalENSG00000095066
TCGA cBioPortalHOOK2
AceView (NCBI)HOOK2
Genatlas (Paris)HOOK2
SOURCE (Princeton)HOOK2
Genetics Home Reference (NIH)HOOK2
Genomic and cartography
GoldenPath hg38 (UCSC)HOOK2  -     chr19:12763003-12775552 -  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOOK2  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathHOOK2 - 19p13.13 [CytoView hg19]  HOOK2 - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000095066
genome Data Viewer NCBIHOOK2 [Mapview hg19]  
OMIM607824   
Gene and transcription
Genbank (Entrez)AF044924 AK129729 BC012443 DB474423
RefSeq transcript (Entrez)NM_001100176 NM_013312
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOOK2
Alternative Splicing GalleryENSG00000095066
Gene ExpressionHOOK2 [ NCBI-GEO ]   HOOK2 [ EBI - ARRAY_EXPRESS ]   HOOK2 [ SEEK ]   HOOK2 [ MEM ]
Gene Expression Viewer (FireBrowse)HOOK2 [ Firebrowse - Broad ]
GenevisibleExpression of HOOK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29911
GTEX Portal (Tissue expression)HOOK2
Human Protein AtlasENSG00000095066-HOOK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96ED9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96ED9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96ED9
Splice isoforms : SwissVarQ96ED9
PhosPhoSitePlusQ96ED9
Domaine pattern : Prosite (Expaxy)CH (PS50021)   
Domains : Interpro (EBI)CH-domain    CH_dom_sf    Hook-like_fam   
Domain families : Pfam (Sanger)HOOK (PF05622)   
Domain families : Pfam (NCBI)pfam05622   
Conserved Domain (NCBI)HOOK2
Blocks (Seattle)HOOK2
SuperfamilyQ96ED9
Human Protein Atlas [tissue]ENSG00000095066-HOOK2 [tissue]
Peptide AtlasQ96ED9
HPRD09698
IPIIPI00002432   IPI00398585   IPI00442919   
Protein Interaction databases
DIP (DOE-UCLA)Q96ED9
IntAct (EBI)Q96ED9
BioGRIDHOOK2
STRING (EMBL)HOOK2
ZODIACHOOK2
Ontologies - Pathways
QuickGOQ96ED9
Ontology : AmiGOprotein binding  cytoplasm  centrosome  centrosome  cytosol  microtubule  endocytosis  endosome organization  lysosome organization  microtubule binding  endosome to lysosome transport  protein transport  cytoskeleton-dependent intracellular transport  HOPS complex  cytoplasmic microtubule organization  identical protein binding  intracellular membrane-bounded organelle  early endosome to late endosome transport  dynein light intermediate chain binding  FHF complex  
Ontology : EGO-EBIprotein binding  cytoplasm  centrosome  centrosome  cytosol  microtubule  endocytosis  endosome organization  lysosome organization  microtubule binding  endosome to lysosome transport  protein transport  cytoskeleton-dependent intracellular transport  HOPS complex  cytoplasmic microtubule organization  identical protein binding  intracellular membrane-bounded organelle  early endosome to late endosome transport  dynein light intermediate chain binding  FHF complex  
NDEx NetworkHOOK2
Atlas of Cancer Signalling NetworkHOOK2
Wikipedia pathwaysHOOK2
Orthology - Evolution
OrthoDB29911
GeneTree (enSembl)ENSG00000095066
Phylogenetic Trees/Animal Genes : TreeFamHOOK2
HOGENOMQ96ED9
Homologs : HomoloGeneHOOK2
Homology/Alignments : Family Browser (UCSC)HOOK2
Gene fusions - Rearrangements
Fusion : MitelmanHOOK2/ACTN3 [19p13.2/11q13.2]  
Fusion : MitelmanHOOK2/MAST1 [19p13.2/19p13.2]  
Fusion : MitelmanHOOK2/RTBDN [19p13.2/19p13.2]  
Fusion PortalHOOK2 19p13.2 MAST1 19p13.2 OV
Fusion PortalHOOK2 19p13.2 RTBDN 19p13.2 LUSC
Fusion : QuiverHOOK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOOK2 [hg38]
dbVarHOOK2
ClinVarHOOK2
MonarchHOOK2
1000_GenomesHOOK2 
Exome Variant ServerHOOK2
GNOMAD BrowserENSG00000095066
Varsome BrowserHOOK2
Genomic Variants (DGV)HOOK2 [DGVbeta]
DECIPHERHOOK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOOK2 
Mutations
ICGC Data PortalHOOK2 
TCGA Data PortalHOOK2 
Broad Tumor PortalHOOK2
OASIS PortalHOOK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOOK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHOOK2
Mutations and Diseases : HGMDHOOK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOOK2
DgiDB (Drug Gene Interaction Database)HOOK2
DoCM (Curated mutations)HOOK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOOK2 (select a term)
intoGenHOOK2
Cancer3DHOOK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607824   
Orphanet
DisGeNETHOOK2
MedgenHOOK2
Genetic Testing Registry HOOK2
NextProtQ96ED9 [Medical]
GENETestsHOOK2
Target ValidationHOOK2
Huge Navigator HOOK2 [HugePedia]
ClinGenHOOK2
Clinical trials, drugs, therapy
MyCancerGenomeHOOK2
Protein Interactions : CTD
Pharm GKB GenePA134986864
PharosQ96ED9
Clinical trialHOOK2
Miscellaneous
canSAR (ICR)HOOK2 (select the gene name)
HarmonizomeHOOK2
DataMed IndexHOOK2
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHOOK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:19:02 CET 2021
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