HOOK2 (hook microtubule tethering protein 2)

2014-08-01  

Identity

HGNC
HOOK2
LOCATION
19p13.13
LOCUSID
29911
ALIAS
HK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29911
MIM: 607824
HGNC: 19885
Ensembl: ENSG00000095066

Variants:

dbSNP: 29911
ClinVar: 29911
TCGA: ENSG00000095066
COSMIC: HOOK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095066ENST00000264827Q96ED9
ENSG00000095066ENST00000397668Q96ED9
ENSG00000095066ENST00000586188K7EJA7
ENSG00000095066ENST00000586719K7EK29
ENSG00000095066ENST00000587178K7EJ65
ENSG00000095066ENST00000588052K7EMG7
ENSG00000095066ENST00000589400K7ENU5
ENSG00000095066ENST00000590839K7EMR5
ENSG00000095066ENST00000592079K7EJ48

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219981992011Hook2 is involved in the morphogenesis of the primary cilium.33
175400362007Hook2 contributes to aggresome formation.22
197939142009Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome.22
292280582017Altered intragenic DNA methylation of HOOK2 gene in adipose tissue from individuals with obesity and type 2 diabetes.4
276249262016Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration.3
323977552020Coding Variants in HOOK2 and GTPBP3 May Contribute to Risk of Primary Angle Closure Glaucoma.0

Citation

Dessen P

HOOK2 (hook microtubule tethering protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54366/hook2