Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HOOK2 (hook microtubule-tethering protein 2)

Identity

Alias_nameshook homolog 2 (Drosophila)
Alias_symbol (synonym)HK2
Other alias
HGNC (Hugo) HOOK2
LocusID (NCBI) 29911
Atlas_Id 54366
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 12873817 and ends at 12886434 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDK2AP2 (11q13.2) / HOOK2 (19p13.2)HOOK2 (19p13.2) / ACTN3 (11q13.2)HOOK2 (19p13.2) / CPAMD8 (19p13.11)
HOOK2 (19p13.2) / MAST1 (19p13.2)HOOK2 (19p13.2) / RTBDN (19p13.2)LUC7L (16p13.3) / HOOK2 (19p13.2)
HOOK2 19p13.2 / MAST1 19p13.2HOOK2 19p13.2 / RTBDN 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HOOK2   19885
Cards
Entrez_Gene (NCBI)HOOK2  29911  hook microtubule-tethering protein 2
AliasesHK2
GeneCards (Weizmann)HOOK2
Ensembl hg19 (Hinxton)ENSG00000095066 [Gene_View]  chr19:12873817-12886434 [Contig_View]  HOOK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000095066 [Gene_View]  chr19:12873817-12886434 [Contig_View]  HOOK2 [Vega]
ICGC DataPortalENSG00000095066
TCGA cBioPortalHOOK2
AceView (NCBI)HOOK2
Genatlas (Paris)HOOK2
WikiGenes29911
SOURCE (Princeton)HOOK2
Genetics Home Reference (NIH)HOOK2
Genomic and cartography
GoldenPath hg19 (UCSC)HOOK2  -     chr19:12873817-12886434 -  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HOOK2  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblHOOK2 - 19p13.2 [CytoView hg19]  HOOK2 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIHOOK2 [Mapview hg19]  HOOK2 [Mapview hg38]
OMIM607824   
Gene and transcription
Genbank (Entrez)AF044924 AK129729 BC012443 DB474423 DQ891339
RefSeq transcript (Entrez)NM_001100176 NM_013312
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)HOOK2
Cluster EST : UnigeneHs.30792 [ NCBI ]
CGAP (NCI)Hs.30792
Alternative Splicing GalleryENSG00000095066
Gene ExpressionHOOK2 [ NCBI-GEO ]   HOOK2 [ EBI - ARRAY_EXPRESS ]   HOOK2 [ SEEK ]   HOOK2 [ MEM ]
Gene Expression Viewer (FireBrowse)HOOK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29911
GTEX Portal (Tissue expression)HOOK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96ED9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96ED9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96ED9
Splice isoforms : SwissVarQ96ED9
PhosPhoSitePlusQ96ED9
Domains : Interpro (EBI)Hook-related_fam   
Domain families : Pfam (Sanger)HOOK (PF05622)   
Domain families : Pfam (NCBI)pfam05622   
Conserved Domain (NCBI)HOOK2
DMDM Disease mutations29911
Blocks (Seattle)HOOK2
SuperfamilyQ96ED9
Human Protein AtlasENSG00000095066
Peptide AtlasQ96ED9
HPRD09698
IPIIPI00002432   IPI00398585   IPI00442919   
Protein Interaction databases
DIP (DOE-UCLA)Q96ED9
IntAct (EBI)Q96ED9
FunCoupENSG00000095066
BioGRIDHOOK2
STRING (EMBL)HOOK2
ZODIACHOOK2
Ontologies - Pathways
QuickGOQ96ED9
Ontology : AmiGOprotein binding  centrosome  cytosol  microtubule  endocytosis  endosome organization  lysosome organization  endosome to lysosome transport  protein transport  HOPS complex  identical protein binding  early endosome to late endosome transport  FHF complex  
Ontology : EGO-EBIprotein binding  centrosome  cytosol  microtubule  endocytosis  endosome organization  lysosome organization  endosome to lysosome transport  protein transport  HOPS complex  identical protein binding  early endosome to late endosome transport  FHF complex  
NDEx NetworkHOOK2
Atlas of Cancer Signalling NetworkHOOK2
Wikipedia pathwaysHOOK2
Orthology - Evolution
OrthoDB29911
GeneTree (enSembl)ENSG00000095066
Phylogenetic Trees/Animal Genes : TreeFamHOOK2
HOVERGENQ96ED9
HOGENOMQ96ED9
Homologs : HomoloGeneHOOK2
Homology/Alignments : Family Browser (UCSC)HOOK2
Gene fusions - Rearrangements
Fusion : MitelmanHOOK2/ACTN3 [19p13.2/11q13.2]  
Fusion : MitelmanHOOK2/MAST1 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanHOOK2/RTBDN [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion: TCGAHOOK2 19p13.2 MAST1 19p13.2 OV
Fusion: TCGAHOOK2 19p13.2 RTBDN 19p13.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOOK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOOK2
dbVarHOOK2
ClinVarHOOK2
1000_GenomesHOOK2 
Exome Variant ServerHOOK2
ExAC (Exome Aggregation Consortium)HOOK2 (select the gene name)
Genetic variants : HAPMAP29911
Genomic Variants (DGV)HOOK2 [DGVbeta]
DECIPHER (Syndromes)19:12873817-12886434  ENSG00000095066
CONAN: Copy Number AnalysisHOOK2 
Mutations
ICGC Data PortalHOOK2 
TCGA Data PortalHOOK2 
Broad Tumor PortalHOOK2
OASIS PortalHOOK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOOK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOOK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOOK2
DgiDB (Drug Gene Interaction Database)HOOK2
DoCM (Curated mutations)HOOK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOOK2 (select a term)
intoGenHOOK2
Cancer3DHOOK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607824   
Orphanet
MedgenHOOK2
Genetic Testing Registry HOOK2
NextProtQ96ED9 [Medical]
TSGene29911
GENETestsHOOK2
Huge Navigator HOOK2 [HugePedia]
snp3D : Map Gene to Disease29911
BioCentury BCIQHOOK2
ClinGenHOOK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29911
Chemical/Pharm GKB GenePA134986864
Clinical trialHOOK2
Miscellaneous
canSAR (ICR)HOOK2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOOK2
EVEXHOOK2
GoPubMedHOOK2
iHOPHOOK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:04:06 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.