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HOOK3 (hook microtubule-tethering protein 3)

Identity

Alias_nameshook homolog 3 (Drosophila)
Alias_symbol (synonym)HK3
Other alias
HGNC (Hugo) HOOK3
LocusID (NCBI) 84376
Atlas_Id 53008
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 42752033 and ends at 42885682 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BMP7 (20q13.31) / HOOK3 (8p11.21)HOOK3 (8p11.21) / HOOK3 (8p11.21)HOOK3 (8p11.21) / IKBKB (8p11.21)
HOOK3 (8p11.21) / MTFR1 (8q13.1)HOOK3 (8p11.21) / PLEKHA2 (8p11.22)HOOK3 (8p11.21) / RET (10q11.21)
HOOK3 (8p11.21) / TM2D2 (8p11.22)JAG1 (20p12.2) / HOOK3 (8p11.21)RET (10q11.21) / HOOK3 (8p11.21)
RNF170 (8p11.21) / HOOK3 (8p11.21)HOOK3 8p11.21 / RET 10q11.21HOOK3 8p11.21 / IKBKB 8p11.21
HOOK3 8p11.21 / MTFR1 8q13.1HOOK3 8p11.21 / PLEKHA2 8p11.22HOOK3 8p11.21 / TM2D2 8p11.22
RNF170 8p11.21 / HOOK3 8p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HOOK3   23576
Cards
Entrez_Gene (NCBI)HOOK3  84376  hook microtubule-tethering protein 3
AliasesHK3
GeneCards (Weizmann)HOOK3
Ensembl hg19 (Hinxton)ENSG00000168172 [Gene_View]  chr8:42752033-42885682 [Contig_View]  HOOK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168172 [Gene_View]  chr8:42752033-42885682 [Contig_View]  HOOK3 [Vega]
ICGC DataPortalENSG00000168172
TCGA cBioPortalHOOK3
AceView (NCBI)HOOK3
Genatlas (Paris)HOOK3
WikiGenes84376
SOURCE (Princeton)HOOK3
Genetics Home Reference (NIH)HOOK3
Genomic and cartography
GoldenPath hg19 (UCSC)HOOK3  -     chr8:42752033-42885682 +  8p11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HOOK3  -     8p11.21   [Description]    (hg38-Dec_2013)
EnsemblHOOK3 - 8p11.21 [CytoView hg19]  HOOK3 - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBIHOOK3 [Mapview hg19]  HOOK3 [Mapview hg38]
OMIM607825   
Gene and transcription
Genbank (Entrez)AK055620 AK090540 AK309224 BC012030 BC013679
RefSeq transcript (Entrez)NM_032410
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)HOOK3
Cluster EST : UnigeneHs.162852 [ NCBI ]
CGAP (NCI)Hs.162852
Alternative Splicing GalleryENSG00000168172
Gene ExpressionHOOK3 [ NCBI-GEO ]   HOOK3 [ EBI - ARRAY_EXPRESS ]   HOOK3 [ SEEK ]   HOOK3 [ MEM ]
Gene Expression Viewer (FireBrowse)HOOK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84376
GTEX Portal (Tissue expression)HOOK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VS8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VS8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VS8
Splice isoforms : SwissVarQ86VS8
PhosPhoSitePlusQ86VS8
Domains : Interpro (EBI)Hook-related_fam   
Domain families : Pfam (Sanger)HOOK (PF05622)   
Domain families : Pfam (NCBI)pfam05622   
Conserved Domain (NCBI)HOOK3
DMDM Disease mutations84376
Blocks (Seattle)HOOK3
SuperfamilyQ86VS8
Human Protein AtlasENSG00000168172
Peptide AtlasQ86VS8
HPRD09699
IPIIPI00031768   IPI00984888   IPI00983039   IPI00977326   
Protein Interaction databases
DIP (DOE-UCLA)Q86VS8
IntAct (EBI)Q86VS8
FunCoupENSG00000168172
BioGRIDHOOK3
STRING (EMBL)HOOK3
ZODIACHOOK3
Ontologies - Pathways
QuickGOQ86VS8
Ontology : AmiGOpericentriolar material  protein binding  cytoplasm  Golgi apparatus  cis-Golgi network  centrosome  microtubule organizing center  cytosol  microtubule  endosome organization  lysosome organization  microtubule binding  endosome to lysosome transport  protein transport  interkinetic nuclear migration  HOPS complex  cytoplasmic microtubule organization  centriolar satellite  microtubule anchoring at centrosome  identical protein binding  early endosome to late endosome transport  negative regulation of neurogenesis  Golgi localization  FHF complex  protein localization to centrosome  neuronal stem cell population maintenance  
Ontology : EGO-EBIpericentriolar material  protein binding  cytoplasm  Golgi apparatus  cis-Golgi network  centrosome  microtubule organizing center  cytosol  microtubule  endosome organization  lysosome organization  microtubule binding  endosome to lysosome transport  protein transport  interkinetic nuclear migration  HOPS complex  cytoplasmic microtubule organization  centriolar satellite  microtubule anchoring at centrosome  identical protein binding  early endosome to late endosome transport  negative regulation of neurogenesis  Golgi localization  FHF complex  protein localization to centrosome  neuronal stem cell population maintenance  
NDEx NetworkHOOK3
Atlas of Cancer Signalling NetworkHOOK3
Wikipedia pathwaysHOOK3
Orthology - Evolution
OrthoDB84376
GeneTree (enSembl)ENSG00000168172
Phylogenetic Trees/Animal Genes : TreeFamHOOK3
HOVERGENQ86VS8
HOGENOMQ86VS8
Homologs : HomoloGeneHOOK3
Homology/Alignments : Family Browser (UCSC)HOOK3
Gene fusions - Rearrangements
Fusion : MitelmanHOOK3/IKBKB [8p11.21/8p11.21]  
Fusion : MitelmanHOOK3/MTFR1 [8p11.21/8q13.1]  [t(8;8)(p11;q13)]  
Fusion : MitelmanHOOK3/PLEKHA2 [8p11.21/8p11.22]  [t(8;8)(p11;p11)]  
Fusion : MitelmanHOOK3/RET [8p11.21/10q11.21]  [t(8;10)(p11;q11)]  
Fusion : MitelmanHOOK3/TM2D2 [8p11.21/8p11.22]  [t(8;8)(p11;p11)]  
Fusion : MitelmanRNF170/HOOK3 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion: TCGAHOOK3 8p11.21 IKBKB 8p11.21 BRCA
Fusion: TCGAHOOK3 8p11.21 MTFR1 8q13.1 BRCA
Fusion: TCGAHOOK3 8p11.21 PLEKHA2 8p11.22 BRCA
Fusion: TCGAHOOK3 8p11.21 TM2D2 8p11.22 BRCA LUAD
Fusion: TCGARNF170 8p11.21 HOOK3 8p11.21 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOOK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOOK3
dbVarHOOK3
ClinVarHOOK3
1000_GenomesHOOK3 
Exome Variant ServerHOOK3
ExAC (Exome Aggregation Consortium)HOOK3 (select the gene name)
Genetic variants : HAPMAP84376
Genomic Variants (DGV)HOOK3 [DGVbeta]
DECIPHER (Syndromes)8:42752033-42885682  ENSG00000168172
CONAN: Copy Number AnalysisHOOK3 
Mutations
ICGC Data PortalHOOK3 
TCGA Data PortalHOOK3 
Broad Tumor PortalHOOK3
OASIS PortalHOOK3 [ Somatic mutations - Copy number]
Cancer Gene: CensusHOOK3 
Somatic Mutations in Cancer : COSMICHOOK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOOK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOOK3
DgiDB (Drug Gene Interaction Database)HOOK3
DoCM (Curated mutations)HOOK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOOK3 (select a term)
intoGenHOOK3
Cancer3DHOOK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607825   
Orphanet
MedgenHOOK3
Genetic Testing Registry HOOK3
NextProtQ86VS8 [Medical]
TSGene84376
GENETestsHOOK3
Huge Navigator HOOK3 [HugePedia]
snp3D : Map Gene to Disease84376
BioCentury BCIQHOOK3
ClinGenHOOK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84376
Chemical/Pharm GKB GenePA134961305
Clinical trialHOOK3
Miscellaneous
canSAR (ICR)HOOK3 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOOK3
EVEXHOOK3
GoPubMedHOOK3
iHOPHOOK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:04:06 CEST 2017

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