HOXA1 (homeobox A1)

2007-02-01 Affiliation

Identity

HGNC

HOXA1

LOCATION

7p15.2

LOCUSID

3198

ALIAS

BSAS,HOX1,HOX1F

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3198
MIM: 142955
HGNC: 5099
Ensembl: ENSG00000105991

Variants:

dbSNP: 3198
ClinVar: 3198
TCGA: ENSG00000105991
COSMIC: HOXA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105991	ENST00000355633	E7ERT8
ENSG00000105991	ENST00000643460	A0A2R8Y4R9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472

References

Pubmed ID	Year	Title	Citations
19598235	2009	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	92
19598235	2009	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	92
16155570	2005	Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development.	75
9463349	1998	Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning.	53
22407312	2012	MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene.	43
12482855	2003	Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene.	42
17967182	2007	Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.	41
21106538	2011	Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217.	37
24559685	2014	Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100.	37
22020899	2012	The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.	35

Citation

Dessen P

HOXA1 (homeobox A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46150/hoxa1