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HOXA10 (homeobox A10)

Identity

Alias_namesHOX1H
HOX1
homeo box A10
Other aliasHOX1.8
PL
HGNC (Hugo) HOXA10
LocusID (NCBI) 3206
Atlas_Id 40846
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 27170591 and ends at 27174336 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TRB () / HOXA10 (7p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  inv(7)(p15q34) TRB/HOXA10::t(7;7)(p15;q34) TRB/HOXA10
T-lineage acute lymphoblastic leukemia (T-ALL)


External links

Nomenclature
HGNC (Hugo)HOXA10   5100
Cards
Entrez_Gene (NCBI)HOXA10  3206  homeobox A10
AliasesHOX1; HOX1.8; HOX1H; PL
GeneCards (Weizmann)HOXA10
Ensembl hg19 (Hinxton)ENSG00000253293 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000253293 [Gene_View]  chr7:27170591-27174336 [Contig_View]  HOXA10 [Vega]
ICGC DataPortalENSG00000253293
TCGA cBioPortalHOXA10
AceView (NCBI)HOXA10
Genatlas (Paris)HOXA10
WikiGenes3206
SOURCE (Princeton)HOXA10
Genetics Home Reference (NIH)HOXA10
Genomic and cartography
GoldenPath hg38 (UCSC)HOXA10  -     chr7:27170591-27174336 -  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXA10  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblHOXA10 - 7p15.2 [CytoView hg19]  HOXA10 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBIHOXA10 [Mapview hg19]  HOXA10 [Mapview hg38]
OMIM142957   
Gene and transcription
Genbank (Entrez)AK312450 AL710880 AV687088 BC007600 BC013971
RefSeq transcript (Entrez)NM_018951 NM_153715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXA10
Cluster EST : UnigeneHs.659350 [ NCBI ]
CGAP (NCI)Hs.659350
Alternative Splicing GalleryENSG00000253293
Gene ExpressionHOXA10 [ NCBI-GEO ]   HOXA10 [ EBI - ARRAY_EXPRESS ]   HOXA10 [ SEEK ]   HOXA10 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXA10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3206
GTEX Portal (Tissue expression)HOXA10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31260   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31260  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31260
Splice isoforms : SwissVarP31260
PhosPhoSitePlusP31260
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXA10
DMDM Disease mutations3206
Blocks (Seattle)HOXA10
SuperfamilyP31260
Human Protein AtlasENSG00000253293
Peptide AtlasP31260
HPRD00845
IPIIPI00941400   IPI00170686   IPI00552625   
Protein Interaction databases
DIP (DOE-UCLA)P31260
IntAct (EBI)P31260
FunCoupENSG00000253293
BioGRIDHOXA10
STRING (EMBL)HOXA10
ZODIACHOXA10
Ontologies - Pathways
QuickGOP31260
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  skeletal system development  protein binding  nucleus  transcription factor complex  cytoplasm  transcription from RNA polymerase II promoter  multicellular organism development  spermatogenesis  single fertilization  male gonad development  anterior/posterior pattern specification  proximal/distal pattern formation  embryonic limb morphogenesis  histone deacetylase binding  positive regulation of transcription from RNA polymerase II promoter  uterus development  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  skeletal system development  protein binding  nucleus  transcription factor complex  cytoplasm  transcription from RNA polymerase II promoter  multicellular organism development  spermatogenesis  single fertilization  male gonad development  anterior/posterior pattern specification  proximal/distal pattern formation  embryonic limb morphogenesis  histone deacetylase binding  positive regulation of transcription from RNA polymerase II promoter  uterus development  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkHOXA10
Atlas of Cancer Signalling NetworkHOXA10
Wikipedia pathwaysHOXA10
Orthology - Evolution
OrthoDB3206
GeneTree (enSembl)ENSG00000253293
Phylogenetic Trees/Animal Genes : TreeFamHOXA10
HOVERGENP31260
HOGENOMP31260
Homologs : HomoloGeneHOXA10
Homology/Alignments : Family Browser (UCSC)HOXA10
Gene fusions - Rearrangements
Fusion : MitelmanTRB/HOXA10 [-/7p15.2]  [inv(7)(p15q34)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXA10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXA10
dbVarHOXA10
ClinVarHOXA10
1000_GenomesHOXA10 
Exome Variant ServerHOXA10
ExAC (Exome Aggregation Consortium)HOXA10 (select the gene name)
Genetic variants : HAPMAP3206
Genomic Variants (DGV)HOXA10 [DGVbeta]
DECIPHERHOXA10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXA10 
Mutations
ICGC Data PortalHOXA10 
TCGA Data PortalHOXA10 
Broad Tumor PortalHOXA10
OASIS PortalHOXA10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXA10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXA10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXA10
DgiDB (Drug Gene Interaction Database)HOXA10
DoCM (Curated mutations)HOXA10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXA10 (select a term)
intoGenHOXA10
Cancer3DHOXA10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142957   
Orphanet
MedgenHOXA10
Genetic Testing Registry HOXA10
NextProtP31260 [Medical]
TSGene3206
GENETestsHOXA10
Huge Navigator HOXA10 [HugePedia]
snp3D : Map Gene to Disease3206
BioCentury BCIQHOXA10
ClinGenHOXA10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3206
Chemical/Pharm GKB GenePA29377
Clinical trialHOXA10
Miscellaneous
canSAR (ICR)HOXA10 (select the gene name)
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXA10
EVEXHOXA10
GoPubMedHOXA10
iHOPHOXA10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:19:16 CEST 2017

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