Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HOXA13 (homeobox A13)

Identity

Alias (NCBI)HOX1
HOX1J
HGNC (Hugo) HOXA13
HGNC Previous nameHOX1J
 HOX1
HGNC Previous namehomeo box A13
LocusID (NCBI) 3209
Atlas_Id 40848
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 27194371 and ends at 27200091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOXA13 (7p15.2) / NUP98 (11p15.4)NUP98 (11p15.4) / HOXA13 (7p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  Pediatric T-Cell Acute Lymphoblastic Leukemia
t(1;11)(q24;p15) NUP98/PRRX1
inv(7)(p15q34) TRB/HOXA10::t(7;7)(p15;q34) TRB/HOXA10
t(7;11)(p15;p15) NUP98/HOXA13

External links

Nomenclature
HGNC (Hugo)HOXA13   5102
Cards
Entrez_Gene (NCBI)HOXA13  3209  homeobox A13
AliasesHOX1; HOX1J
GeneCards (Weizmann)HOXA13
Ensembl hg19 (Hinxton)ENSG00000106031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106031 [Gene_View]  ENSG00000106031 [Sequence]  chr7:27194371-27200091 [Contig_View]  HOXA13 [Vega]
ICGC DataPortalENSG00000106031
TCGA cBioPortalHOXA13
AceView (NCBI)HOXA13
Genatlas (Paris)HOXA13
WikiGenes3209
SOURCE (Princeton)HOXA13
Genetics Home Reference (NIH)HOXA13
Genomic and cartography
GoldenPath hg38 (UCSC)HOXA13  -     chr7:27194371-27200091 -  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXA13  -     7p15.2   [Description]    (hg19-Feb_2009)
GoldenPathHOXA13 - 7p15.2 [CytoView hg19]  HOXA13 - 7p15.2 [CytoView hg38]
ImmunoBaseENSG00000106031
genome Data Viewer NCBIHOXA13 [Mapview hg19]  
OMIM140000   142959   176305   
Gene and transcription
Genbank (Entrez)AL597666 BC016712 BC075791
RefSeq transcript (Entrez)NM_000522
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXA13
Alternative Splicing GalleryENSG00000106031
Gene ExpressionHOXA13 [ NCBI-GEO ]   HOXA13 [ EBI - ARRAY_EXPRESS ]   HOXA13 [ SEEK ]   HOXA13 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXA13 [ Firebrowse - Broad ]
GenevisibleExpression of HOXA13 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3209
GTEX Portal (Tissue expression)HOXA13
Human Protein AtlasENSG00000106031-HOXA13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31271   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31271  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31271
Splice isoforms : SwissVarP31271
PhosPhoSitePlusP31271
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    HoxA13_N   
Domain families : Pfam (Sanger)Homeodomain (PF00046)    HoxA13_N (PF12284)   
Domain families : Pfam (NCBI)pfam00046    pfam12284   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXA13
DMDM Disease mutations3209
Blocks (Seattle)HOXA13
PDB (RSDB)2L7Z   
PDB Europe2L7Z   
PDB (PDBSum)2L7Z   
PDB (IMB)2L7Z   
Structural Biology KnowledgeBase2L7Z   
SCOP (Structural Classification of Proteins)2L7Z   
CATH (Classification of proteins structures)2L7Z   
SuperfamilyP31271
Human Protein Atlas [tissue]ENSG00000106031-HOXA13 [tissue]
Peptide AtlasP31271
HPRD00847
IPIIPI00305850   
Protein Interaction databases
DIP (DOE-UCLA)P31271
IntAct (EBI)P31271
FunCoupENSG00000106031
BioGRIDHOXA13
STRING (EMBL)HOXA13
ZODIACHOXA13
Ontologies - Pathways
QuickGOP31271
Ontology : AmiGOnuclear chromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  skeletal system development  DNA binding  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  sequence-specific DNA binding  intermediate filament cytoskeleton  
Ontology : EGO-EBInuclear chromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  skeletal system development  DNA binding  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  sequence-specific DNA binding  intermediate filament cytoskeleton  
NDEx NetworkHOXA13
Atlas of Cancer Signalling NetworkHOXA13
Wikipedia pathwaysHOXA13
Orthology - Evolution
OrthoDB3209
GeneTree (enSembl)ENSG00000106031
Phylogenetic Trees/Animal Genes : TreeFamHOXA13
HOGENOMP31271
Homologs : HomoloGeneHOXA13
Homology/Alignments : Family Browser (UCSC)HOXA13
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/HOXA13 [11p15.4/7p15.2]  
Fusion : QuiverHOXA13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXA13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXA13
dbVarHOXA13
ClinVarHOXA13
MonarchHOXA13
1000_GenomesHOXA13 
Exome Variant ServerHOXA13
GNOMAD BrowserENSG00000106031
Varsome BrowserHOXA13
Genetic variants : HAPMAP3209
Genomic Variants (DGV)HOXA13 [DGVbeta]
DECIPHERHOXA13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXA13 
Mutations
ICGC Data PortalHOXA13 
TCGA Data PortalHOXA13 
Broad Tumor PortalHOXA13
OASIS PortalHOXA13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXA13  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHOXA13
Mutations and Diseases : HGMDHOXA13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXA13
DgiDB (Drug Gene Interaction Database)HOXA13
DoCM (Curated mutations)HOXA13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXA13 (select a term)
intoGenHOXA13
Cancer3DHOXA13(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140000    142959    176305   
Orphanet2259    2668   
DisGeNETHOXA13
MedgenHOXA13
Genetic Testing Registry HOXA13
NextProtP31271 [Medical]
TSGene3209
GENETestsHOXA13
Target ValidationHOXA13
Huge Navigator HOXA13 [HugePedia]
snp3D : Map Gene to Disease3209
BioCentury BCIQHOXA13
ClinGenHOXA13
Clinical trials, drugs, therapy
Protein Interactions : CTD3209
Pharm GKB GenePA29379
Clinical trialHOXA13
Miscellaneous
canSAR (ICR)HOXA13 (select the gene name)
HarmonizomeHOXA13
DataMed IndexHOXA13
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXA13
EVEXHOXA13
GoPubMedHOXA13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:14:40 CEST 2020
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