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HOXA13 (homeobox A13)

Identity

Alias_namesHOX1J
HOX1
homeo box A13
Other alias
HGNC (Hugo) HOXA13
LocusID (NCBI) 3209
Atlas_Id 40848
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 27196880 and ends at 27200106 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOXA13 (7p15.2) / NUP98 (11p15.4)NUP98 (11p15.4) / HOXA13 (7p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  Pediatric T-Cell Acute Lymphoblastic Leukemia
t(1;11)(q23;p15) NUP98/PRRX1
inv(7)(p15q34) TRB/HOXA10::t(7;7)(p15;q34) TRB/HOXA10
t(7;11)(p15;p15) NUP98/HOXA13

External links

Nomenclature
HGNC (Hugo)HOXA13   5102
Cards
Entrez_Gene (NCBI)HOXA13  3209  homeobox A13
AliasesHOX1; HOX1J
GeneCards (Weizmann)HOXA13
Ensembl hg19 (Hinxton)ENSG00000106031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106031 [Gene_View]  chr7:27196880-27200106 [Contig_View]  HOXA13 [Vega]
ICGC DataPortalENSG00000106031
TCGA cBioPortalHOXA13
AceView (NCBI)HOXA13
Genatlas (Paris)HOXA13
WikiGenes3209
SOURCE (Princeton)HOXA13
Genetics Home Reference (NIH)HOXA13
Genomic and cartography
GoldenPath hg38 (UCSC)HOXA13  -     chr7:27196880-27200106 -  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXA13  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblHOXA13 - 7p15.2 [CytoView hg19]  HOXA13 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBIHOXA13 [Mapview hg19]  HOXA13 [Mapview hg38]
OMIM140000   142959   176305   
Gene and transcription
Genbank (Entrez)AL597666 BC016712 BC075791
RefSeq transcript (Entrez)NM_000522
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXA13
Cluster EST : UnigeneHs.592172 [ NCBI ]
CGAP (NCI)Hs.592172
Alternative Splicing GalleryENSG00000106031
Gene ExpressionHOXA13 [ NCBI-GEO ]   HOXA13 [ EBI - ARRAY_EXPRESS ]   HOXA13 [ SEEK ]   HOXA13 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXA13 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3209
GTEX Portal (Tissue expression)HOXA13
Human Protein AtlasENSG00000106031-HOXA13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31271   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31271  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31271
Splice isoforms : SwissVarP31271
PhosPhoSitePlusP31271
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    HoxA13_N   
Domain families : Pfam (Sanger)Homeobox (PF00046)    HoxA13_N (PF12284)   
Domain families : Pfam (NCBI)pfam00046    pfam12284   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXA13
DMDM Disease mutations3209
Blocks (Seattle)HOXA13
PDB (SRS)2L7Z   
PDB (PDBSum)2L7Z   
PDB (IMB)2L7Z   
PDB (RSDB)2L7Z   
Structural Biology KnowledgeBase2L7Z   
SCOP (Structural Classification of Proteins)2L7Z   
CATH (Classification of proteins structures)2L7Z   
SuperfamilyP31271
Human Protein Atlas [tissue]ENSG00000106031-HOXA13 [tissue]
Peptide AtlasP31271
HPRD00847
IPIIPI00305850   
Protein Interaction databases
DIP (DOE-UCLA)P31271
IntAct (EBI)P31271
FunCoupENSG00000106031
BioGRIDHOXA13
STRING (EMBL)HOXA13
ZODIACHOXA13
Ontologies - Pathways
QuickGOP31271
Ontology : AmiGOskeletal system development  DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  sequence-specific DNA binding  sequence-specific DNA binding  
Ontology : EGO-EBIskeletal system development  DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  sequence-specific DNA binding  sequence-specific DNA binding  
NDEx NetworkHOXA13
Atlas of Cancer Signalling NetworkHOXA13
Wikipedia pathwaysHOXA13
Orthology - Evolution
OrthoDB3209
GeneTree (enSembl)ENSG00000106031
Phylogenetic Trees/Animal Genes : TreeFamHOXA13
HOVERGENP31271
HOGENOMP31271
Homologs : HomoloGeneHOXA13
Homology/Alignments : Family Browser (UCSC)HOXA13
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/HOXA13 [11p15.4/7p15.2]  [t(7;11)(p15;p15)]  
Fusion : QuiverHOXA13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXA13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXA13
dbVarHOXA13
ClinVarHOXA13
1000_GenomesHOXA13 
Exome Variant ServerHOXA13
ExAC (Exome Aggregation Consortium)ENSG00000106031
GNOMAD BrowserENSG00000106031
Genetic variants : HAPMAP3209
Genomic Variants (DGV)HOXA13 [DGVbeta]
DECIPHERHOXA13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXA13 
Mutations
ICGC Data PortalHOXA13 
TCGA Data PortalHOXA13 
Broad Tumor PortalHOXA13
OASIS PortalHOXA13 [ Somatic mutations - Copy number]
Cancer Gene: CensusHOXA13 
Somatic Mutations in Cancer : COSMICHOXA13  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXA13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXA13
DgiDB (Drug Gene Interaction Database)HOXA13
DoCM (Curated mutations)HOXA13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXA13 (select a term)
intoGenHOXA13
Cancer3DHOXA13(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140000    142959    176305   
Orphanet2259    2668   
DisGeNETHOXA13
MedgenHOXA13
Genetic Testing Registry HOXA13
NextProtP31271 [Medical]
TSGene3209
GENETestsHOXA13
Target ValidationHOXA13
Huge Navigator HOXA13 [HugePedia]
snp3D : Map Gene to Disease3209
BioCentury BCIQHOXA13
ClinGenHOXA13
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3209
Chemical/Pharm GKB GenePA29379
Clinical trialHOXA13
Miscellaneous
canSAR (ICR)HOXA13 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXA13
EVEXHOXA13
GoPubMedHOXA13
iHOPHOXA13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon May 14 11:51:03 CEST 2018
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