Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HOXB2 (homeobox B2)

Identity

Alias (NCBI)HOX2
HOX2H
Hox-2.8
K8
HGNC (Hugo) HOXB2
HGNC Previous nameHOX2
 HOX2H
HGNC Previous namehomeo box B2
LocusID (NCBI) 3212
Atlas_Id 52538
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48542656 and ends at 48545031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK::NUP214 in Childhood

External links

 

Nomenclature
HGNC (Hugo)HOXB2   5113
Cards
Entrez_Gene (NCBI)HOXB2    homeobox B2
AliasesHOX2; HOX2H; Hox-2.8; K8
GeneCards (Weizmann)HOXB2
Ensembl hg19 (Hinxton)ENSG00000173917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173917 [Gene_View]  ENSG00000173917 [Sequence]  chr17:48542656-48545031 [Contig_View]  HOXB2 [Vega]
ICGC DataPortalENSG00000173917
TCGA cBioPortalHOXB2
AceView (NCBI)HOXB2
Genatlas (Paris)HOXB2
SOURCE (Princeton)HOXB2
Genetics Home Reference (NIH)HOXB2
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB2  -     chr17:48542656-48545031 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB2  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathHOXB2 - 17q21.32 [CytoView hg19]  HOXB2 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000173917
Genome Data Viewer NCBIHOXB2 [Mapview hg19]  
OMIM142967   
Gene and transcription
Genbank (Entrez)AA450237 BC038968 BC074805 BC074806 M73999
RefSeq transcript (Entrez)NM_002145
Consensus coding sequences : CCDS (NCBI)HOXB2
Gene ExpressionHOXB2 [ NCBI-GEO ]   HOXB2 [ EBI - ARRAY_EXPRESS ]   HOXB2 [ SEEK ]   HOXB2 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB2 [ Firebrowse - Broad ]
GenevisibleExpression of HOXB2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3212
GTEX Portal (Tissue expression)HOXB2
Human Protein AtlasENSG00000173917-HOXB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14652   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14652  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14652
PhosPhoSitePlusP14652
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB2
SuperfamilyP14652
AlphaFold pdb e-kbP14652   
Human Protein Atlas [tissue]ENSG00000173917-HOXB2 [tissue]
HPRD00854
Protein Interaction databases
DIP (DOE-UCLA)P14652
IntAct (EBI)P14652
BioGRIDHOXB2
STRING (EMBL)HOXB2
ZODIACHOXB2
Ontologies - Pathways
QuickGOP14652
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  morphogenesis of an epithelial sheet  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription by RNA polymerase II  multicellular organism development  blood circulation  anterior/posterior pattern specification  dorsal/ventral pattern formation  rhombomere 3 development  rhombomere 4 development  facial nerve structural organization  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  embryonic skeletal system morphogenesis  neural nucleus development  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  morphogenesis of an epithelial sheet  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription by RNA polymerase II  multicellular organism development  blood circulation  anterior/posterior pattern specification  dorsal/ventral pattern formation  rhombomere 3 development  rhombomere 4 development  facial nerve structural organization  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  embryonic skeletal system morphogenesis  neural nucleus development  sequence-specific double-stranded DNA binding  
NDEx NetworkHOXB2
Atlas of Cancer Signalling NetworkHOXB2
Wikipedia pathwaysHOXB2
Orthology - Evolution
OrthoDB3212
GeneTree (enSembl)ENSG00000173917
Phylogenetic Trees/Animal Genes : TreeFamHOXB2
Homologs : HomoloGeneHOXB2
Homology/Alignments : Family Browser (UCSC)HOXB2
Gene fusions - Rearrangements
Fusion : QuiverHOXB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB2
dbVarHOXB2
ClinVarHOXB2
MonarchHOXB2
1000_GenomesHOXB2 
Exome Variant ServerHOXB2
GNOMAD BrowserENSG00000173917
Varsome BrowserHOXB2
ACMGHOXB2 variants
VarityP14652
Genomic Variants (DGV)HOXB2 [DGVbeta]
DECIPHERHOXB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB2 
Mutations
ICGC Data PortalHOXB2 
TCGA Data PortalHOXB2 
Broad Tumor PortalHOXB2
OASIS PortalHOXB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHOXB2
Mutations and Diseases : HGMDHOXB2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHOXB2
DgiDB (Drug Gene Interaction Database)HOXB2
DoCM (Curated mutations)HOXB2
CIViC (Clinical Interpretations of Variants in Cancer)HOXB2
Cancer3DHOXB2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142967   
Orphanet
DisGeNETHOXB2
MedgenHOXB2
Genetic Testing Registry HOXB2
NextProtP14652 [Medical]
GENETestsHOXB2
Target ValidationHOXB2
Huge Navigator HOXB2 [HugePedia]
ClinGenHOXB2
Clinical trials, drugs, therapy
MyCancerGenomeHOXB2
Protein Interactions : CTDHOXB2
Pharm GKB GenePA29389
PharosP14652
Clinical trialHOXB2
Miscellaneous
canSAR (ICR)HOXB2
HarmonizomeHOXB2
ARCHS4HOXB2
DataMed IndexHOXB2
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHOXB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:14:30 CET 2022
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