Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HOXB2 (homeobox B2)

Identity

Alias_namesHOX2
HOX2H
homeo box B2
Other aliasHox-2.8
K8
HGNC (Hugo) HOXB2
LocusID (NCBI) 3212
Atlas_Id 52538
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48542656 and ends at 48545031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK/NUP214 in Childhood

External links

Nomenclature
HGNC (Hugo)HOXB2   5113
Cards
Entrez_Gene (NCBI)HOXB2  3212  homeobox B2
AliasesHOX2; HOX2H; Hox-2.8; K8
GeneCards (Weizmann)HOXB2
Ensembl hg19 (Hinxton)ENSG00000173917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173917 [Gene_View]  ENSG00000173917 [Sequence]  chr17:48542656-48545031 [Contig_View]  HOXB2 [Vega]
ICGC DataPortalENSG00000173917
TCGA cBioPortalHOXB2
AceView (NCBI)HOXB2
Genatlas (Paris)HOXB2
WikiGenes3212
SOURCE (Princeton)HOXB2
Genetics Home Reference (NIH)HOXB2
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB2  -     chr17:48542656-48545031 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB2  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblHOXB2 - 17q21.32 [CytoView hg19]  HOXB2 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIHOXB2 [Mapview hg19]  HOXB2 [Mapview hg38]
OMIM142967   
Gene and transcription
Genbank (Entrez)AA450237 BC038968 BC074805 BC074806 M73999
RefSeq transcript (Entrez)NM_002145
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXB2
Cluster EST : UnigeneHs.514289 [ NCBI ]
CGAP (NCI)Hs.514289
Alternative Splicing GalleryENSG00000173917
Gene ExpressionHOXB2 [ NCBI-GEO ]   HOXB2 [ EBI - ARRAY_EXPRESS ]   HOXB2 [ SEEK ]   HOXB2 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3212
GTEX Portal (Tissue expression)HOXB2
Human Protein AtlasENSG00000173917-HOXB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14652   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14652  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14652
Splice isoforms : SwissVarP14652
PhosPhoSitePlusP14652
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB2
DMDM Disease mutations3212
Blocks (Seattle)HOXB2
SuperfamilyP14652
Human Protein Atlas [tissue]ENSG00000173917-HOXB2 [tissue]
Peptide AtlasP14652
HPRD00854
IPIIPI00027261   IPI00383021   
Protein Interaction databases
DIP (DOE-UCLA)P14652
IntAct (EBI)P14652
FunCoupENSG00000173917
BioGRIDHOXB2
STRING (EMBL)HOXB2
ZODIACHOXB2
Ontologies - Pathways
QuickGOP14652
Ontology : AmiGOtranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  morphogenesis of an epithelial sheet  nucleus  nucleoplasm  cytosol  transcription by RNA polymerase II  multicellular organism development  blood circulation  anterior/posterior pattern specification  dorsal/ventral pattern formation  nuclear speck  rhombomere 3 development  rhombomere 4 development  facial nerve structural organization  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  embryonic skeletal system morphogenesis  neural nucleus development  
Ontology : EGO-EBItranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  morphogenesis of an epithelial sheet  nucleus  nucleoplasm  cytosol  transcription by RNA polymerase II  multicellular organism development  blood circulation  anterior/posterior pattern specification  dorsal/ventral pattern formation  nuclear speck  rhombomere 3 development  rhombomere 4 development  facial nerve structural organization  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  embryonic skeletal system morphogenesis  neural nucleus development  
NDEx NetworkHOXB2
Atlas of Cancer Signalling NetworkHOXB2
Wikipedia pathwaysHOXB2
Orthology - Evolution
OrthoDB3212
GeneTree (enSembl)ENSG00000173917
Phylogenetic Trees/Animal Genes : TreeFamHOXB2
HOVERGENP14652
HOGENOMP14652
Homologs : HomoloGeneHOXB2
Homology/Alignments : Family Browser (UCSC)HOXB2
Gene fusions - Rearrangements
Fusion : QuiverHOXB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB2
dbVarHOXB2
ClinVarHOXB2
1000_GenomesHOXB2 
Exome Variant ServerHOXB2
ExAC (Exome Aggregation Consortium)ENSG00000173917
GNOMAD BrowserENSG00000173917
Genetic variants : HAPMAP3212
Genomic Variants (DGV)HOXB2 [DGVbeta]
DECIPHERHOXB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB2 
Mutations
ICGC Data PortalHOXB2 
TCGA Data PortalHOXB2 
Broad Tumor PortalHOXB2
OASIS PortalHOXB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXB2
DgiDB (Drug Gene Interaction Database)HOXB2
DoCM (Curated mutations)HOXB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXB2 (select a term)
intoGenHOXB2
Cancer3DHOXB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142967   
Orphanet
DisGeNETHOXB2
MedgenHOXB2
Genetic Testing Registry HOXB2
NextProtP14652 [Medical]
TSGene3212
GENETestsHOXB2
Target ValidationHOXB2
Huge Navigator HOXB2 [HugePedia]
snp3D : Map Gene to Disease3212
BioCentury BCIQHOXB2
ClinGenHOXB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3212
Chemical/Pharm GKB GenePA29389
Clinical trialHOXB2
Miscellaneous
canSAR (ICR)HOXB2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXB2
EVEXHOXB2
GoPubMedHOXB2
iHOPHOXB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:29:34 CEST 2018
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