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HOXB3 (homeobox B3)

Identity

Alias_namesHOX2
HOX2G
homeo box B3
Other aliasHox-2.7
HGNC (Hugo) HOXB3
LocusID (NCBI) 3213
Atlas_Id 53269
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48548870 and ends at 48582622 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOXB3 (17q21.32) / HOXB3 (17q21.32)HOXB3 (17q21.32) / PTK2 (8q24.3)HOXB3 (17q21.32) / PTPRA (20p13)
RARA (17q21.2) / HOXB3 (17q21.32)SKAP1 (17q21.32) / HOXB3 (17q21.32)RARA 17q21.2 / HOXB3 17q21.32
SKAP1 17q21.32 / HOXB3 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK/NUP214 in Childhood


External links

Nomenclature
HGNC (Hugo)HOXB3   5114
Cards
Entrez_Gene (NCBI)HOXB3  3213  homeobox B3
AliasesHOX2; HOX2G; Hox-2.7
GeneCards (Weizmann)HOXB3
Ensembl hg19 (Hinxton)ENSG00000120093 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120093 [Gene_View]  chr17:48548870-48582622 [Contig_View]  HOXB3 [Vega]
ICGC DataPortalENSG00000120093
TCGA cBioPortalHOXB3
AceView (NCBI)HOXB3
Genatlas (Paris)HOXB3
WikiGenes3213
SOURCE (Princeton)HOXB3
Genetics Home Reference (NIH)HOXB3
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB3  -     chr17:48548870-48582622 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB3  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblHOXB3 - 17q21.32 [CytoView hg19]  HOXB3 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIHOXB3 [Mapview hg19]  HOXB3 [Mapview hg38]
OMIM142966   
Gene and transcription
Genbank (Entrez)AI633956 AK000839 AK027609 AK291182 AK299226
RefSeq transcript (Entrez)NM_001330322 NM_001330323 NM_002146
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXB3
Cluster EST : UnigeneHs.687723 [ NCBI ]
CGAP (NCI)Hs.687723
Alternative Splicing GalleryENSG00000120093
Gene ExpressionHOXB3 [ NCBI-GEO ]   HOXB3 [ EBI - ARRAY_EXPRESS ]   HOXB3 [ SEEK ]   HOXB3 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3213
GTEX Portal (Tissue expression)HOXB3
Human Protein AtlasENSG00000120093-HOXB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14651   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14651  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14651
Splice isoforms : SwissVarP14651
PhosPhoSitePlusP14651
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)DUF4074    Homeobox-like    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)DUF4074 (PF13293)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam13293    pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB3
DMDM Disease mutations3213
Blocks (Seattle)HOXB3
SuperfamilyP14651
Human Protein Atlas [tissue]ENSG00000120093-HOXB3 [tissue]
Peptide AtlasP14651
HPRD00853
IPIIPI00027259   IPI01020781   IPI01022378   IPI00947155   IPI00947370   IPI00947552   
Protein Interaction databases
DIP (DOE-UCLA)P14651
IntAct (EBI)P14651
FunCoupENSG00000120093
BioGRIDHOXB3
STRING (EMBL)HOXB3
ZODIACHOXB3
Ontologies - Pathways
QuickGOP14651
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  angiogenesis  hematopoietic progenitor cell differentiation  nucleus  transcription from RNA polymerase II promoter  anterior/posterior pattern specification  rhombomere development  glossopharyngeal nerve morphogenesis  thyroid gland development  positive regulation of transcription from RNA polymerase II promoter  embryonic skeletal system morphogenesis  regulation of neurogenesis  cartilage development  definitive hemopoiesis  face development  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  angiogenesis  hematopoietic progenitor cell differentiation  nucleus  transcription from RNA polymerase II promoter  anterior/posterior pattern specification  rhombomere development  glossopharyngeal nerve morphogenesis  thyroid gland development  positive regulation of transcription from RNA polymerase II promoter  embryonic skeletal system morphogenesis  regulation of neurogenesis  cartilage development  definitive hemopoiesis  face development  
NDEx NetworkHOXB3
Atlas of Cancer Signalling NetworkHOXB3
Wikipedia pathwaysHOXB3
Orthology - Evolution
OrthoDB3213
GeneTree (enSembl)ENSG00000120093
Phylogenetic Trees/Animal Genes : TreeFamHOXB3
HOVERGENP14651
HOGENOMP14651
Homologs : HomoloGeneHOXB3
Homology/Alignments : Family Browser (UCSC)HOXB3
Gene fusions - Rearrangements
Fusion : MitelmanRARA/HOXB3 [17q21.2/17q21.32]  [t(17;17)(q21;q21)]  
Fusion : MitelmanSKAP1/HOXB3 [17q21.32/17q21.32]  [t(17;17)(q21;q21)]  
Fusion: TCGA_MDACCRARA 17q21.2 HOXB3 17q21.32 BRCA
Fusion: TCGA_MDACCSKAP1 17q21.32 HOXB3 17q21.32 LUAD
Tumor Fusion PortalHOXB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB3
dbVarHOXB3
ClinVarHOXB3
1000_GenomesHOXB3 
Exome Variant ServerHOXB3
ExAC (Exome Aggregation Consortium)ENSG00000120093
GNOMAD BrowserENSG00000120093
Genetic variants : HAPMAP3213
Genomic Variants (DGV)HOXB3 [DGVbeta]
DECIPHERHOXB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB3 
Mutations
ICGC Data PortalHOXB3 
TCGA Data PortalHOXB3 
Broad Tumor PortalHOXB3
OASIS PortalHOXB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXB3
DgiDB (Drug Gene Interaction Database)HOXB3
DoCM (Curated mutations)HOXB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXB3 (select a term)
intoGenHOXB3
Cancer3DHOXB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142966   
Orphanet
DisGeNETHOXB3
MedgenHOXB3
Genetic Testing Registry HOXB3
NextProtP14651 [Medical]
TSGene3213
GENETestsHOXB3
Target ValidationHOXB3
Huge Navigator HOXB3 [HugePedia]
snp3D : Map Gene to Disease3213
BioCentury BCIQHOXB3
ClinGenHOXB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3213
Chemical/Pharm GKB GenePA29390
Clinical trialHOXB3
Miscellaneous
canSAR (ICR)HOXB3 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXB3
EVEXHOXB3
GoPubMedHOXB3
iHOPHOXB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:16:39 CET 2017

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