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HOXB4 (homeobox B4)

Identity

Alias_namesHOX2
HOX2F
homeo box B4
Other aliasHOX-2.6
HGNC (Hugo) HOXB4
LocusID (NCBI) 3214
Atlas_Id 46471
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48575507 and ends at 48578381 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK/NUP214 in Childhood


External links

Nomenclature
HGNC (Hugo)HOXB4   5115
Cards
Entrez_Gene (NCBI)HOXB4  3214  homeobox B4
AliasesHOX-2.6; HOX2; HOX2F
GeneCards (Weizmann)HOXB4
Ensembl hg19 (Hinxton)ENSG00000182742 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182742 [Gene_View]  chr17:48575507-48578381 [Contig_View]  HOXB4 [Vega]
ICGC DataPortalENSG00000182742
TCGA cBioPortalHOXB4
AceView (NCBI)HOXB4
Genatlas (Paris)HOXB4
WikiGenes3214
SOURCE (Princeton)HOXB4
Genetics Home Reference (NIH)HOXB4
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB4  -     chr17:48575507-48578381 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB4  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblHOXB4 - 17q21.32 [CytoView hg19]  HOXB4 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIHOXB4 [Mapview hg19]  HOXB4 [Mapview hg38]
OMIM142965   
Gene and transcription
Genbank (Entrez)AL137449 BC049204 BM972328 BU161354
RefSeq transcript (Entrez)NM_024015
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXB4
Cluster EST : UnigeneHs.664706 [ NCBI ]
CGAP (NCI)Hs.664706
Alternative Splicing GalleryENSG00000182742
Gene ExpressionHOXB4 [ NCBI-GEO ]   HOXB4 [ EBI - ARRAY_EXPRESS ]   HOXB4 [ SEEK ]   HOXB4 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3214
GTEX Portal (Tissue expression)HOXB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17483   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17483  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17483
Splice isoforms : SwissVarP17483
PhosPhoSitePlusP17483
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_antennapedia    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB4
DMDM Disease mutations3214
Blocks (Seattle)HOXB4
SuperfamilyP17483
Human Protein AtlasENSG00000182742
Peptide AtlasP17483
HPRD07032
IPIIPI00014540   IPI00985236   
Protein Interaction databases
DIP (DOE-UCLA)P17483
IntAct (EBI)P17483
FunCoupENSG00000182742
BioGRIDHOXB4
STRING (EMBL)HOXB4
ZODIACHOXB4
Ontologies - Pathways
QuickGOP17483
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  morphogenesis of an epithelial sheet  transcription factor activity, sequence-specific DNA binding  nucleus  centrosome  transcription, DNA-templated  cell proliferation  anterior/posterior pattern specification  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  somatic stem cell division  spleen development  bone marrow development  embryonic skeletal system morphogenesis  definitive hemopoiesis  hematopoietic stem cell differentiation  positive regulation of stem cell differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  morphogenesis of an epithelial sheet  transcription factor activity, sequence-specific DNA binding  nucleus  centrosome  transcription, DNA-templated  cell proliferation  anterior/posterior pattern specification  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  somatic stem cell division  spleen development  bone marrow development  embryonic skeletal system morphogenesis  definitive hemopoiesis  hematopoietic stem cell differentiation  positive regulation of stem cell differentiation  
NDEx NetworkHOXB4
Atlas of Cancer Signalling NetworkHOXB4
Wikipedia pathwaysHOXB4
Orthology - Evolution
OrthoDB3214
GeneTree (enSembl)ENSG00000182742
Phylogenetic Trees/Animal Genes : TreeFamHOXB4
HOVERGENP17483
HOGENOMP17483
Homologs : HomoloGeneHOXB4
Homology/Alignments : Family Browser (UCSC)HOXB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB4
dbVarHOXB4
ClinVarHOXB4
1000_GenomesHOXB4 
Exome Variant ServerHOXB4
ExAC (Exome Aggregation Consortium)HOXB4 (select the gene name)
Genetic variants : HAPMAP3214
Genomic Variants (DGV)HOXB4 [DGVbeta]
DECIPHERHOXB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB4 
Mutations
ICGC Data PortalHOXB4 
TCGA Data PortalHOXB4 
Broad Tumor PortalHOXB4
OASIS PortalHOXB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXB4
DgiDB (Drug Gene Interaction Database)HOXB4
DoCM (Curated mutations)HOXB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXB4 (select a term)
intoGenHOXB4
Cancer3DHOXB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142965   
Orphanet
MedgenHOXB4
Genetic Testing Registry HOXB4
NextProtP17483 [Medical]
TSGene3214
GENETestsHOXB4
Target ValidationHOXB4
Huge Navigator HOXB4 [HugePedia]
snp3D : Map Gene to Disease3214
BioCentury BCIQHOXB4
ClinGenHOXB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3214
Chemical/Pharm GKB GenePA29391
Clinical trialHOXB4
Miscellaneous
canSAR (ICR)HOXB4 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXB4
EVEXHOXB4
GoPubMedHOXB4
iHOPHOXB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:55:38 CEST 2017

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