HOXB4 (homeobox B4)

2007-02-01  

Identity

HGNC
HOXB4
LOCATION
17q21.32
LOCUSID
3214
ALIAS
HOX-2.6,HOX2,HOX2F

Other Information

Locus ID:

NCBI: 3214
MIM: 142965
HGNC: 5115
Ensembl: ENSG00000182742

Variants:

dbSNP: 3214
ClinVar: 3214
TCGA: ENSG00000182742
COSMIC: HOXB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182742ENST00000332503P17483

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA30128KITGeneMultilinkAnnotationassociated17253940

References

Pubmed IDYearTitleCitations
124068972003High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation.43
149662722004Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.31
121304962002Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells.27
127916562003NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.26
224382492012Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells.23
262029332016Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression.18
185118802008Forced expression of HoxB4 enhances hematopoietic differentiation by human embryonic stem cells.15
215466952011HOX genes in pancreatic development and cancer.15
175102182007Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species.14
177848292007Recombinant HoxB4 fusion proteins enhance hematopoietic differentiation of human embryonic stem cells.12

Citation

Dessen P

HOXB4 (homeobox B4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46471/hoxb4