HOXB5 (homeobox B5)

2007-10-01  

Identity

HGNC
HOXB5
LOCATION
17q21.32
LOCUSID
3215
ALIAS
HHO.C10,HOX2,HOX2A,HU-1,Hox2.1

Other Information

Locus ID:

NCBI: 3215
MIM: 142960
HGNC: 5116
Ensembl: ENSG00000120075

Variants:

dbSNP: 3215
ClinVar: 3215
TCGA: ENSG00000120075
COSMIC: HOXB5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120075ENST00000239151P09067

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
224846272012A genome-wide association meta-analysis identifies new childhood obesity loci.137
176230562007DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.48
128971402003HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.27
129500742003HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts.27
226037952012Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus.26
227682382012A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer.16
259997932015HOXB5 Promotes the Proliferation and Invasion of Breast Cancer Cells.16
264671572015HOXB5 induces invasion and migration through direct transcriptional up-regulation of β-catenin in human gastric carcinoma.16
291701272018miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.15
283379582018Knockdown of Homeobox B5 (HOXB5) Inhibits Cell Proliferation, Migration, and Invasion in Non-Small Cell Lung Cancer Cells Through Inactivation of the Wnt/β-Catenin Pathway.14

Citation

Dessen P

HOXB5 (homeobox B5)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49769/hoxb5