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HOXB6 (homeobox B6)

Identity

Alias (NCBI)HOX2
HOX2B
HU-2
Hox-2.2
HGNC (Hugo) HOXB6
HGNC Previous nameHOX2
 HOX2B
HGNC Previous namehomeo box B6
LocusID (NCBI) 3216
Atlas_Id 64392
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48595751 and ends at 48604986 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK::NUP214 in Childhood


External links

 

Nomenclature
HGNC (Hugo)HOXB6   5117
Cards
Entrez_Gene (NCBI)HOXB6    homeobox B6
AliasesHOX2; HOX2B; HU-2; Hox-2.2
GeneCards (Weizmann)HOXB6
Ensembl hg19 (Hinxton)ENSG00000108511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108511 [Gene_View]  ENSG00000108511 [Sequence]  chr17:48595751-48604986 [Contig_View]  HOXB6 [Vega]
ICGC DataPortalENSG00000108511
TCGA cBioPortalHOXB6
AceView (NCBI)HOXB6
Genatlas (Paris)HOXB6
SOURCE (Princeton)HOXB6
Genetics Home Reference (NIH)HOXB6
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB6  -     chr17:48595751-48604986 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB6  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathHOXB6 - 17q21.32 [CytoView hg19]  HOXB6 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000108511
Genome Data Viewer NCBIHOXB6 [Mapview hg19]  
OMIM142961   
Gene and transcription
Genbank (Entrez)AA053456 AA610066 AI283987 AI352188 AK292200
RefSeq transcript (Entrez)NM_001369397 NM_018952 NM_156036 NM_156037
Consensus coding sequences : CCDS (NCBI)HOXB6
Gene ExpressionHOXB6 [ NCBI-GEO ]   HOXB6 [ EBI - ARRAY_EXPRESS ]   HOXB6 [ SEEK ]   HOXB6 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB6 [ Firebrowse - Broad ]
GenevisibleExpression of HOXB6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3216
GTEX Portal (Tissue expression)HOXB6
Human Protein AtlasENSG00000108511-HOXB6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17509
PhosPhoSitePlusP17509
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_antennapedia    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB6
SuperfamilyP17509
AlphaFold pdb e-kbP17509   
Human Protein Atlas [tissue]ENSG00000108511-HOXB6 [tissue]
HPRD00849
Protein Interaction databases
DIP (DOE-UCLA)P17509
IntAct (EBI)P17509
BioGRIDHOXB6
STRING (EMBL)HOXB6
ZODIACHOXB6
Ontologies - Pathways
QuickGOP17509
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA binding  protein binding  nucleus  regulation of transcription by RNA polymerase II  anterior/posterior pattern specification  erythrocyte homeostasis  embryonic skeletal system morphogenesis  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA binding  protein binding  nucleus  regulation of transcription by RNA polymerase II  anterior/posterior pattern specification  erythrocyte homeostasis  embryonic skeletal system morphogenesis  sequence-specific double-stranded DNA binding  
NDEx NetworkHOXB6
Atlas of Cancer Signalling NetworkHOXB6
Wikipedia pathwaysHOXB6
Orthology - Evolution
OrthoDB3216
GeneTree (enSembl)ENSG00000108511
Phylogenetic Trees/Animal Genes : TreeFamHOXB6
Homologs : HomoloGeneHOXB6
Homology/Alignments : Family Browser (UCSC)HOXB6
Gene fusions - Rearrangements
Fusion : QuiverHOXB6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB6
dbVarHOXB6
ClinVarHOXB6
MonarchHOXB6
1000_GenomesHOXB6 
Exome Variant ServerHOXB6
GNOMAD BrowserENSG00000108511
Varsome BrowserHOXB6
ACMGHOXB6 variants
VarityP17509
Genomic Variants (DGV)HOXB6 [DGVbeta]
DECIPHERHOXB6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB6 
Mutations
ICGC Data PortalHOXB6 
TCGA Data PortalHOXB6 
Broad Tumor PortalHOXB6
OASIS PortalHOXB6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHOXB6
Mutations and Diseases : HGMDHOXB6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHOXB6
DgiDB (Drug Gene Interaction Database)HOXB6
DoCM (Curated mutations)HOXB6
CIViC (Clinical Interpretations of Variants in Cancer)HOXB6
Cancer3DHOXB6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142961   
Orphanet
DisGeNETHOXB6
MedgenHOXB6
Genetic Testing Registry HOXB6
NextProtP17509 [Medical]
GENETestsHOXB6
Target ValidationHOXB6
Huge Navigator HOXB6 [HugePedia]
ClinGenHOXB6
Clinical trials, drugs, therapy
MyCancerGenomeHOXB6
Protein Interactions : CTDHOXB6
Pharm GKB GenePA29393
PharosP17509
Clinical trialHOXB6
Miscellaneous
canSAR (ICR)HOXB6
HarmonizomeHOXB6
ARCHS4HOXB6
DataMed IndexHOXB6
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHOXB6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:22:05 CET 2022

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