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HOXB6 (homeobox B6)

Identity

Alias_namesHOX2
HOX2B
homeo box B6
Other aliasHU-2
Hox-2.2
HGNC (Hugo) HOXB6
LocusID (NCBI) 3216
Atlas_Id 64392
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48595737 and ends at 48604972 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK/NUP214 in Childhood


External links

Nomenclature
HGNC (Hugo)HOXB6   5117
Cards
Entrez_Gene (NCBI)HOXB6  3216  homeobox B6
AliasesHOX2; HOX2B; HU-2; Hox-2.2
GeneCards (Weizmann)HOXB6
Ensembl hg19 (Hinxton)ENSG00000108511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108511 [Gene_View]  chr17:48595737-48604972 [Contig_View]  HOXB6 [Vega]
ICGC DataPortalENSG00000108511
TCGA cBioPortalHOXB6
AceView (NCBI)HOXB6
Genatlas (Paris)HOXB6
WikiGenes3216
SOURCE (Princeton)HOXB6
Genetics Home Reference (NIH)HOXB6
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB6  -     chr17:48595737-48604972 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB6  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblHOXB6 - 17q21.32 [CytoView hg19]  HOXB6 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIHOXB6 [Mapview hg19]  HOXB6 [Mapview hg38]
OMIM142961   
Gene and transcription
Genbank (Entrez)AI283987 AI352188 AK292200 AW370639 BC014651
RefSeq transcript (Entrez)NM_018952 NM_156036 NM_156037
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXB6
Cluster EST : UnigeneHs.98428 [ NCBI ]
CGAP (NCI)Hs.98428
Alternative Splicing GalleryENSG00000108511
Gene ExpressionHOXB6 [ NCBI-GEO ]   HOXB6 [ EBI - ARRAY_EXPRESS ]   HOXB6 [ SEEK ]   HOXB6 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3216
GTEX Portal (Tissue expression)HOXB6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17509
Splice isoforms : SwissVarP17509
PhosPhoSitePlusP17509
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_antennapedia    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB6
DMDM Disease mutations3216
Blocks (Seattle)HOXB6
SuperfamilyP17509
Human Protein AtlasENSG00000108511
Peptide AtlasP17509
HPRD00849
IPIIPI00015075   IPI00216597   IPI00782933   
Protein Interaction databases
DIP (DOE-UCLA)P17509
IntAct (EBI)P17509
FunCoupENSG00000108511
BioGRIDHOXB6
STRING (EMBL)HOXB6
ZODIACHOXB6
Ontologies - Pathways
QuickGOP17509
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  RNA binding  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  anterior/posterior pattern specification  erythrocyte homeostasis  sequence-specific DNA binding  embryonic skeletal system morphogenesis  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  RNA binding  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  anterior/posterior pattern specification  erythrocyte homeostasis  sequence-specific DNA binding  embryonic skeletal system morphogenesis  
NDEx NetworkHOXB6
Atlas of Cancer Signalling NetworkHOXB6
Wikipedia pathwaysHOXB6
Orthology - Evolution
OrthoDB3216
GeneTree (enSembl)ENSG00000108511
Phylogenetic Trees/Animal Genes : TreeFamHOXB6
HOVERGENP17509
HOGENOMP17509
Homologs : HomoloGeneHOXB6
Homology/Alignments : Family Browser (UCSC)HOXB6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB6
dbVarHOXB6
ClinVarHOXB6
1000_GenomesHOXB6 
Exome Variant ServerHOXB6
ExAC (Exome Aggregation Consortium)HOXB6 (select the gene name)
Genetic variants : HAPMAP3216
Genomic Variants (DGV)HOXB6 [DGVbeta]
DECIPHERHOXB6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB6 
Mutations
ICGC Data PortalHOXB6 
TCGA Data PortalHOXB6 
Broad Tumor PortalHOXB6
OASIS PortalHOXB6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXB6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXB6
DgiDB (Drug Gene Interaction Database)HOXB6
DoCM (Curated mutations)HOXB6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXB6 (select a term)
intoGenHOXB6
Cancer3DHOXB6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142961   
Orphanet
MedgenHOXB6
Genetic Testing Registry HOXB6
NextProtP17509 [Medical]
TSGene3216
GENETestsHOXB6
Target ValidationHOXB6
Huge Navigator HOXB6 [HugePedia]
snp3D : Map Gene to Disease3216
BioCentury BCIQHOXB6
ClinGenHOXB6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3216
Chemical/Pharm GKB GenePA29393
Clinical trialHOXB6
Miscellaneous
canSAR (ICR)HOXB6 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXB6
EVEXHOXB6
GoPubMedHOXB6
iHOPHOXB6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:52:41 CEST 2017

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