HOXB7 (homeobox B7)

2003-02-01  

Identity

HGNC
HOXB7
LOCATION
17q21.32
LOCUSID
3217
ALIAS
HHO.C1,HOX2,HOX2C,Hox-2.3

Other Information

Locus ID:

NCBI: 3217
MIM: 142962
HGNC: 5118
Ensembl: ENSG00000260027

Variants:

dbSNP: 3217
ClinVar: 3217
TCGA: ENSG00000260027
COSMIC: HOXB7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000260027ENST00000239165P09629

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
248534212014P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression.163
170186092006HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition.75
214745782011HOXB7 as a prognostic factor and mediator of colorectal cancer progression.45
204802032010MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma.42
216903422012The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.40
285332242017miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.28
199568432010Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis.26
226037952012Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus.26
229149032013HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma.26
261800422015HOXB7 Is an ERα Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance.23

Citation

Dessen P

HOXB7 (homeobox B7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40851/hoxb7