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HOXB8 (homeobox B8)

Identity

Alias_namesHOX2
HOX2D
homeo box B8
Other aliasHox-2.4
HGNC (Hugo) HOXB8
LocusID (NCBI) 3218
Atlas_Id 53424
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48612346 and ends at 48614939 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOXB8 (17q21.32) / DIAPH1 (5q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK/NUP214 in Childhood


External links

Nomenclature
HGNC (Hugo)HOXB8   5119
Cards
Entrez_Gene (NCBI)HOXB8  3218  homeobox B8
AliasesHOX2; HOX2D; Hox-2.4
GeneCards (Weizmann)HOXB8
Ensembl hg19 (Hinxton)ENSG00000120068 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120068 [Gene_View]  chr17:48612346-48614939 [Contig_View]  HOXB8 [Vega]
ICGC DataPortalENSG00000120068
TCGA cBioPortalHOXB8
AceView (NCBI)HOXB8
Genatlas (Paris)HOXB8
WikiGenes3218
SOURCE (Princeton)HOXB8
Genetics Home Reference (NIH)HOXB8
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB8  -     chr17:48612346-48614939 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB8  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblHOXB8 - 17q21.32 [CytoView hg19]  HOXB8 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIHOXB8 [Mapview hg19]  HOXB8 [Mapview hg38]
OMIM142963   
Gene and transcription
Genbank (Entrez)AI277015 AI672407 AK096222 AW612644 BC141560
RefSeq transcript (Entrez)NM_024016
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXB8
Cluster EST : UnigeneHs.514292 [ NCBI ]
CGAP (NCI)Hs.514292
Alternative Splicing GalleryENSG00000120068
Gene ExpressionHOXB8 [ NCBI-GEO ]   HOXB8 [ EBI - ARRAY_EXPRESS ]   HOXB8 [ SEEK ]   HOXB8 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3218
GTEX Portal (Tissue expression)HOXB8
Human Protein AtlasENSG00000120068-HOXB8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17481   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17481  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17481
Splice isoforms : SwissVarP17481
PhosPhoSitePlusP17481
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB8
DMDM Disease mutations3218
Blocks (Seattle)HOXB8
SuperfamilyP17481
Human Protein Atlas [tissue]ENSG00000120068-HOXB8 [tissue]
Peptide AtlasP17481
HPRD00851
IPIIPI00014536   
Protein Interaction databases
DIP (DOE-UCLA)P17481
IntAct (EBI)P17481
FunCoupENSG00000120068
BioGRIDHOXB8
STRING (EMBL)HOXB8
ZODIACHOXB8
Ontologies - Pathways
QuickGOP17481
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  grooming behavior  adult locomotory behavior  anterior/posterior pattern specification  sensory perception of pain  dorsal spinal cord development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  embryonic skeletal system morphogenesis  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  grooming behavior  adult locomotory behavior  anterior/posterior pattern specification  sensory perception of pain  dorsal spinal cord development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  embryonic skeletal system morphogenesis  
NDEx NetworkHOXB8
Atlas of Cancer Signalling NetworkHOXB8
Wikipedia pathwaysHOXB8
Orthology - Evolution
OrthoDB3218
GeneTree (enSembl)ENSG00000120068
Phylogenetic Trees/Animal Genes : TreeFamHOXB8
HOVERGENP17481
HOGENOMP17481
Homologs : HomoloGeneHOXB8
Homology/Alignments : Family Browser (UCSC)HOXB8
Gene fusions - Rearrangements
Tumor Fusion PortalHOXB8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB8
dbVarHOXB8
ClinVarHOXB8
1000_GenomesHOXB8 
Exome Variant ServerHOXB8
ExAC (Exome Aggregation Consortium)ENSG00000120068
GNOMAD BrowserENSG00000120068
Genetic variants : HAPMAP3218
Genomic Variants (DGV)HOXB8 [DGVbeta]
DECIPHERHOXB8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB8 
Mutations
ICGC Data PortalHOXB8 
TCGA Data PortalHOXB8 
Broad Tumor PortalHOXB8
OASIS PortalHOXB8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXB8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXB8
DgiDB (Drug Gene Interaction Database)HOXB8
DoCM (Curated mutations)HOXB8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXB8 (select a term)
intoGenHOXB8
Cancer3DHOXB8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142963   
Orphanet
DisGeNETHOXB8
MedgenHOXB8
Genetic Testing Registry HOXB8
NextProtP17481 [Medical]
TSGene3218
GENETestsHOXB8
Target ValidationHOXB8
Huge Navigator HOXB8 [HugePedia]
snp3D : Map Gene to Disease3218
BioCentury BCIQHOXB8
ClinGenHOXB8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3218
Chemical/Pharm GKB GenePA29395
Clinical trialHOXB8
Miscellaneous
canSAR (ICR)HOXB8 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXB8
EVEXHOXB8
GoPubMedHOXB8
iHOPHOXB8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:16:40 CET 2017

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