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HOXB8 (homeobox B8)

Identity

Alias (NCBI)HOX2
HOX2D
Hox-2.4
HGNC (Hugo) HOXB8
HGNC Previous nameHOX2
 HOX2D
HGNC Previous namehomeo box B8
LocusID (NCBI) 3218
Atlas_Id 53424
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48612346 and ends at 48615292 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOXB8 (17q21.32)::DIAPH1 (5q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;9)(p22;q34) DEK::NUP214 in Childhood
t(17;22)(q21;q12) EWSR1::HOXB8


External links

 

Nomenclature
HGNC (Hugo)HOXB8   5119
Cards
Entrez_Gene (NCBI)HOXB8    homeobox B8
AliasesHOX2; HOX2D; Hox-2.4
GeneCards (Weizmann)HOXB8
Ensembl hg19 (Hinxton)ENSG00000120068 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120068 [Gene_View]  ENSG00000120068 [Sequence]  chr17:48612346-48615292 [Contig_View]  HOXB8 [Vega]
ICGC DataPortalENSG00000120068
TCGA cBioPortalHOXB8
AceView (NCBI)HOXB8
Genatlas (Paris)HOXB8
SOURCE (Princeton)HOXB8
Genetics Home Reference (NIH)HOXB8
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB8  -     chr17:48612346-48615292 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB8  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathHOXB8 - 17q21.32 [CytoView hg19]  HOXB8 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000120068
Genome Data Viewer NCBIHOXB8 [Mapview hg19]  
OMIM142963   
Gene and transcription
Genbank (Entrez)AI277015 AI672407 AK096222 AW612644 BF761142
RefSeq transcript (Entrez)NM_024016
Consensus coding sequences : CCDS (NCBI)HOXB8
Gene ExpressionHOXB8 [ NCBI-GEO ]   HOXB8 [ EBI - ARRAY_EXPRESS ]   HOXB8 [ SEEK ]   HOXB8 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB8 [ Firebrowse - Broad ]
GenevisibleExpression of HOXB8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3218
GTEX Portal (Tissue expression)HOXB8
Human Protein AtlasENSG00000120068-HOXB8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17481   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17481  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17481
PhosPhoSitePlusP17481
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB8
SuperfamilyP17481
AlphaFold pdb e-kbP17481   
Human Protein Atlas [tissue]ENSG00000120068-HOXB8 [tissue]
HPRD00851
Protein Interaction databases
DIP (DOE-UCLA)P17481
IntAct (EBI)P17481
BioGRIDHOXB8
STRING (EMBL)HOXB8
ZODIACHOXB8
Ontologies - Pathways
QuickGOP17481
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  grooming behavior  adult locomotory behavior  anterior/posterior pattern specification  sensory perception of pain  dorsal spinal cord development  negative regulation of myeloid cell differentiation  embryonic skeletal system morphogenesis  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  grooming behavior  adult locomotory behavior  anterior/posterior pattern specification  sensory perception of pain  dorsal spinal cord development  negative regulation of myeloid cell differentiation  embryonic skeletal system morphogenesis  sequence-specific double-stranded DNA binding  
NDEx NetworkHOXB8
Atlas of Cancer Signalling NetworkHOXB8
Wikipedia pathwaysHOXB8
Orthology - Evolution
OrthoDB3218
GeneTree (enSembl)ENSG00000120068
Phylogenetic Trees/Animal Genes : TreeFamHOXB8
Homologs : HomoloGeneHOXB8
Homology/Alignments : Family Browser (UCSC)HOXB8
Gene fusions - Rearrangements
Fusion : QuiverHOXB8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB8
dbVarHOXB8
ClinVarHOXB8
MonarchHOXB8
1000_GenomesHOXB8 
Exome Variant ServerHOXB8
GNOMAD BrowserENSG00000120068
Varsome BrowserHOXB8
ACMGHOXB8 variants
VarityP17481
Genomic Variants (DGV)HOXB8 [DGVbeta]
DECIPHERHOXB8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB8 
Mutations
ICGC Data PortalHOXB8 
TCGA Data PortalHOXB8 
Broad Tumor PortalHOXB8
OASIS PortalHOXB8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHOXB8
Mutations and Diseases : HGMDHOXB8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHOXB8
DgiDB (Drug Gene Interaction Database)HOXB8
DoCM (Curated mutations)HOXB8
CIViC (Clinical Interpretations of Variants in Cancer)HOXB8
Cancer3DHOXB8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142963   
Orphanet
DisGeNETHOXB8
MedgenHOXB8
Genetic Testing Registry HOXB8
NextProtP17481 [Medical]
GENETestsHOXB8
Target ValidationHOXB8
Huge Navigator HOXB8 [HugePedia]
ClinGenHOXB8
Clinical trials, drugs, therapy
MyCancerGenomeHOXB8
Protein Interactions : CTDHOXB8
Pharm GKB GenePA29395
PharosP17481
Clinical trialHOXB8
Miscellaneous
canSAR (ICR)HOXB8
HarmonizomeHOXB8
ARCHS4HOXB8
DataMed IndexHOXB8
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHOXB8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:37:23 CET 2022

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