Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HOXB9 (homeobox B9)

Identity

Alias_namesHOX2E
HOX2
homeo box B9
Other aliasHOX-2.5
HGNC (Hugo) HOXB9
LocusID (NCBI) 3219
Atlas_Id 47552
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48621157 and ends at 48626473 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCAS3 (17q23.2) / HOXB9 (17q21.32)ECE2 (3q27.1) / HOXB9 (17q21.32)HOXB9 (17q21.32) / RPL26 (17p13.1)
NIPBL (5p13.2) / HOXB9 (17q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
t(6;9)(p22;q34) DEK/NUP214 in Childhood


External links

Nomenclature
HGNC (Hugo)HOXB9   5120
Cards
Entrez_Gene (NCBI)HOXB9  3219  homeobox B9
AliasesHOX-2.5; HOX2; HOX2E
GeneCards (Weizmann)HOXB9
Ensembl hg19 (Hinxton)ENSG00000170689 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170689 [Gene_View]  chr17:48621157-48626473 [Contig_View]  HOXB9 [Vega]
ICGC DataPortalENSG00000170689
TCGA cBioPortalHOXB9
AceView (NCBI)HOXB9
Genatlas (Paris)HOXB9
WikiGenes3219
SOURCE (Princeton)HOXB9
Genetics Home Reference (NIH)HOXB9
Genomic and cartography
GoldenPath hg38 (UCSC)HOXB9  -     chr17:48621157-48626473 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXB9  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblHOXB9 - 17q21.32 [CytoView hg19]  HOXB9 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIHOXB9 [Mapview hg19]  HOXB9 [Mapview hg38]
OMIM142964   
Gene and transcription
Genbank (Entrez)AK026084 AK056123 AK056414 AK315480 BC015565
RefSeq transcript (Entrez)NM_024017
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXB9
Cluster EST : UnigeneHs.463350 [ NCBI ]
CGAP (NCI)Hs.463350
Alternative Splicing GalleryENSG00000170689
Gene ExpressionHOXB9 [ NCBI-GEO ]   HOXB9 [ EBI - ARRAY_EXPRESS ]   HOXB9 [ SEEK ]   HOXB9 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXB9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3219
GTEX Portal (Tissue expression)HOXB9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17482   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17482  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17482
Splice isoforms : SwissVarP17482
PhosPhoSitePlusP17482
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    Hox9_activation_N    HXA9/HXB9/HXC9   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Hox9_act (PF04617)   
Domain families : Pfam (NCBI)pfam00046    pfam04617   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXB9
DMDM Disease mutations3219
Blocks (Seattle)HOXB9
SuperfamilyP17482
Human Protein AtlasENSG00000170689
Peptide AtlasP17482
HPRD00852
IPIIPI00014539   IPI00902521   IPI01022289   
Protein Interaction databases
DIP (DOE-UCLA)P17482
IntAct (EBI)P17482
FunCoupENSG00000170689
BioGRIDHOXB9
STRING (EMBL)HOXB9
ZODIACHOXB9
Ontologies - Pathways
QuickGOP17482
Ontology : AmiGOprotein binding  nucleoplasm  mitochondrion  transcription, DNA-templated  anterior/posterior pattern specification  mammary gland development  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  embryonic skeletal system development  canonical Wnt signaling pathway  cell chemotaxis  
Ontology : EGO-EBIprotein binding  nucleoplasm  mitochondrion  transcription, DNA-templated  anterior/posterior pattern specification  mammary gland development  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  embryonic skeletal system development  canonical Wnt signaling pathway  cell chemotaxis  
Pathways : BIOCARTABTG family proteins and cell cycle regulation [Genes]   
NDEx NetworkHOXB9
Atlas of Cancer Signalling NetworkHOXB9
Wikipedia pathwaysHOXB9
Orthology - Evolution
OrthoDB3219
GeneTree (enSembl)ENSG00000170689
Phylogenetic Trees/Animal Genes : TreeFamHOXB9
HOVERGENP17482
HOGENOMP17482
Homologs : HomoloGeneHOXB9
Homology/Alignments : Family Browser (UCSC)HOXB9
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/HOXB9 [17q23.2/17q21.32]  [t(17;17)(q21;q23)]  
Fusion : MitelmanNIPBL/HOXB9 [5p13.2/17q21.32]  [t(5;17)(p13;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXB9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXB9
dbVarHOXB9
ClinVarHOXB9
1000_GenomesHOXB9 
Exome Variant ServerHOXB9
ExAC (Exome Aggregation Consortium)HOXB9 (select the gene name)
Genetic variants : HAPMAP3219
Genomic Variants (DGV)HOXB9 [DGVbeta]
DECIPHERHOXB9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXB9 
Mutations
ICGC Data PortalHOXB9 
TCGA Data PortalHOXB9 
Broad Tumor PortalHOXB9
OASIS PortalHOXB9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXB9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXB9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXB9
DgiDB (Drug Gene Interaction Database)HOXB9
DoCM (Curated mutations)HOXB9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXB9 (select a term)
intoGenHOXB9
Cancer3DHOXB9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142964   
Orphanet
MedgenHOXB9
Genetic Testing Registry HOXB9
NextProtP17482 [Medical]
TSGene3219
GENETestsHOXB9
Target ValidationHOXB9
Huge Navigator HOXB9 [HugePedia]
snp3D : Map Gene to Disease3219
BioCentury BCIQHOXB9
ClinGenHOXB9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3219
Chemical/Pharm GKB GenePA29396
Clinical trialHOXB9
Miscellaneous
canSAR (ICR)HOXB9 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXB9
EVEXHOXB9
GoPubMedHOXB9
iHOPHOXB9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:12:07 CEST 2017

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