Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HOXC11 (homeobox C11)

Identity

Alias_namesHOX3H
homeo box C11
HGNC (Hugo) HOXC11
LocusID (NCBI) 3227
Atlas_Id 40852
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 54366910 and ends at 54370203 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HOXC11 (12q13.13) / NUP98 (11p15.4)NUP98 (11p15.4) / HOXC11 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;11)(q23;p15) NUP98/PRRX1


External links

Nomenclature
HGNC (Hugo)HOXC11   5123
Cards
Entrez_Gene (NCBI)HOXC11  3227  homeobox C11
AliasesHOX3H
GeneCards (Weizmann)HOXC11
Ensembl hg19 (Hinxton)ENSG00000123388 [Gene_View]  chr12:54366910-54370203 [Contig_View]  HOXC11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000123388 [Gene_View]  chr12:54366910-54370203 [Contig_View]  HOXC11 [Vega]
ICGC DataPortalENSG00000123388
TCGA cBioPortalHOXC11
AceView (NCBI)HOXC11
Genatlas (Paris)HOXC11
WikiGenes3227
SOURCE (Princeton)HOXC11
Genetics Home Reference (NIH)HOXC11
Genomic and cartography
GoldenPath hg19 (UCSC)HOXC11  -     chr12:54366910-54370203 +  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HOXC11  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblHOXC11 - 12q13.13 [CytoView hg19]  HOXC11 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIHOXC11 [Mapview hg19]  HOXC11 [Mapview hg38]
OMIM605559   
Gene and transcription
Genbank (Entrez)AJ000041 AK291946 BC001543 HQ447392 X99630
RefSeq transcript (Entrez)NM_014212
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)HOXC11
Cluster EST : UnigeneHs.127562 [ NCBI ]
CGAP (NCI)Hs.127562
Alternative Splicing GalleryENSG00000123388
Gene ExpressionHOXC11 [ NCBI-GEO ]   HOXC11 [ EBI - ARRAY_EXPRESS ]   HOXC11 [ SEEK ]   HOXC11 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXC11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3227
GTEX Portal (Tissue expression)HOXC11
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43248   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43248  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43248
Splice isoforms : SwissVarO43248
PhosPhoSitePlusO43248
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)DUF3528    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    Homeodomain-like   
Domain families : Pfam (Sanger)DUF3528 (PF12045)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam12045    pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXC11
DMDM Disease mutations3227
Blocks (Seattle)HOXC11
SuperfamilyO43248
Human Protein AtlasENSG00000123388
Peptide AtlasO43248
HPRD09275
IPIIPI00011610   IPI01022231   
Protein Interaction databases
DIP (DOE-UCLA)O43248
IntAct (EBI)O43248
FunCoupENSG00000123388
BioGRIDHOXC11
STRING (EMBL)HOXC11
ZODIACHOXC11
Ontologies - Pathways
QuickGOO43248
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  metanephros development  organ induction  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  endoderm development  anterior/posterior pattern specification  proximal/distal pattern formation  embryonic digit morphogenesis  positive regulation of transcription from RNA polymerase II promoter  embryonic skeletal joint morphogenesis  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  metanephros development  organ induction  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  endoderm development  anterior/posterior pattern specification  proximal/distal pattern formation  embryonic digit morphogenesis  positive regulation of transcription from RNA polymerase II promoter  embryonic skeletal joint morphogenesis  
NDEx NetworkHOXC11
Atlas of Cancer Signalling NetworkHOXC11
Wikipedia pathwaysHOXC11
Orthology - Evolution
OrthoDB3227
GeneTree (enSembl)ENSG00000123388
Phylogenetic Trees/Animal Genes : TreeFamHOXC11
HOVERGENO43248
HOGENOMO43248
Homologs : HomoloGeneHOXC11
Homology/Alignments : Family Browser (UCSC)HOXC11
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/HOXC11 [11p15.4/12q13.13]  [t(11;12)(p15;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXC11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXC11
dbVarHOXC11
ClinVarHOXC11
1000_GenomesHOXC11 
Exome Variant ServerHOXC11
ExAC (Exome Aggregation Consortium)HOXC11 (select the gene name)
Genetic variants : HAPMAP3227
Genomic Variants (DGV)HOXC11 [DGVbeta]
DECIPHER (Syndromes)12:54366910-54370203  ENSG00000123388
CONAN: Copy Number AnalysisHOXC11 
Mutations
ICGC Data PortalHOXC11 
TCGA Data PortalHOXC11 
Broad Tumor PortalHOXC11
OASIS PortalHOXC11 [ Somatic mutations - Copy number]
Cancer Gene: CensusHOXC11 
Somatic Mutations in Cancer : COSMICHOXC11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXC11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXC11
DgiDB (Drug Gene Interaction Database)HOXC11
DoCM (Curated mutations)HOXC11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXC11 (select a term)
intoGenHOXC11
Cancer3DHOXC11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605559   
Orphanet
MedgenHOXC11
Genetic Testing Registry HOXC11
NextProtO43248 [Medical]
TSGene3227
GENETestsHOXC11
Huge Navigator HOXC11 [HugePedia]
snp3D : Map Gene to Disease3227
BioCentury BCIQHOXC11
ClinGenHOXC11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3227
Chemical/Pharm GKB GenePA29398
Clinical trialHOXC11
Miscellaneous
canSAR (ICR)HOXC11 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXC11
EVEXHOXC11
GoPubMedHOXC11
iHOPHOXC11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:39:41 CET 2016

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