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HOXC6 (homeobox C6)

Identity

Alias_namesHOX3C
HOX3
homeo box C6
Other aliasCP25
HHO.C8
HGNC (Hugo) HOXC6
LocusID (NCBI) 3223
Atlas_Id 44032
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 54028410 and ends at 54030823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HOXC6 (12q13.13) / PYM1 (12q13.2)SLC25A39 (17q21.31) / HOXC6 (12q13.13)SLC30A9 (4p13) / HOXC6 (12q13.13)
HOXC6 12q13.13 / WIBG 12q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  T-lineage acute lymphoblastic leukemia (T-ALL)


External links

Nomenclature
HGNC (Hugo)HOXC6   5128
Cards
Entrez_Gene (NCBI)HOXC6  3223  homeobox C6
AliasesCP25; HHO.C8; HOX3; HOX3C
GeneCards (Weizmann)HOXC6
Ensembl hg19 (Hinxton)ENSG00000197757 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197757 [Gene_View]  chr12:54028410-54030823 [Contig_View]  HOXC6 [Vega]
ICGC DataPortalENSG00000197757
TCGA cBioPortalHOXC6
AceView (NCBI)HOXC6
Genatlas (Paris)HOXC6
WikiGenes3223
SOURCE (Princeton)HOXC6
Genetics Home Reference (NIH)HOXC6
Genomic and cartography
GoldenPath hg38 (UCSC)HOXC6  -     chr12:54028410-54030823 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXC6  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblHOXC6 - 12q13.13 [CytoView hg19]  HOXC6 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIHOXC6 [Mapview hg19]  HOXC6 [Mapview hg38]
OMIM142972   
Gene and transcription
Genbank (Entrez)AK314829 AW445186 BC074844 BC074845 BF034547
RefSeq transcript (Entrez)NM_004503 NM_153693
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXC6
Cluster EST : UnigeneHs.549040 [ NCBI ]
CGAP (NCI)Hs.549040
Alternative Splicing GalleryENSG00000197757
Gene ExpressionHOXC6 [ NCBI-GEO ]   HOXC6 [ EBI - ARRAY_EXPRESS ]   HOXC6 [ SEEK ]   HOXC6 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3223
GTEX Portal (Tissue expression)HOXC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09630   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09630  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09630
Splice isoforms : SwissVarP09630
PhosPhoSitePlusP09630
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXC6
DMDM Disease mutations3223
Blocks (Seattle)HOXC6
SuperfamilyP09630
Human Protein AtlasENSG00000197757
Peptide AtlasP09630
HPRD00858
IPIIPI00015921   IPI00221294   IPI00966488   IPI00793306   
Protein Interaction databases
DIP (DOE-UCLA)P09630
IntAct (EBI)P09630
FunCoupENSG00000197757
BioGRIDHOXC6
STRING (EMBL)HOXC6
ZODIACHOXC6
Ontologies - Pathways
QuickGOP09630
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  transcription corepressor activity  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  multicellular organism development  anterior/posterior pattern specification  sequence-specific DNA binding  embryonic skeletal system development  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  transcription corepressor activity  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  multicellular organism development  anterior/posterior pattern specification  sequence-specific DNA binding  embryonic skeletal system development  negative regulation of nucleic acid-templated transcription  
NDEx NetworkHOXC6
Atlas of Cancer Signalling NetworkHOXC6
Wikipedia pathwaysHOXC6
Orthology - Evolution
OrthoDB3223
GeneTree (enSembl)ENSG00000197757
Phylogenetic Trees/Animal Genes : TreeFamHOXC6
HOVERGENP09630
HOGENOMP09630
Homologs : HomoloGeneHOXC6
Homology/Alignments : Family Browser (UCSC)HOXC6
Gene fusions - Rearrangements
Fusion : MitelmanHOXC6/WIBG [12q13.13/12q13.2]  
Fusion: TCGAHOXC6 12q13.13 WIBG 12q13.2 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXC6
dbVarHOXC6
ClinVarHOXC6
1000_GenomesHOXC6 
Exome Variant ServerHOXC6
ExAC (Exome Aggregation Consortium)HOXC6 (select the gene name)
Genetic variants : HAPMAP3223
Genomic Variants (DGV)HOXC6 [DGVbeta]
DECIPHERHOXC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXC6 
Mutations
ICGC Data PortalHOXC6 
TCGA Data PortalHOXC6 
Broad Tumor PortalHOXC6
OASIS PortalHOXC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXC6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXC6
DgiDB (Drug Gene Interaction Database)HOXC6
DoCM (Curated mutations)HOXC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXC6 (select a term)
intoGenHOXC6
Cancer3DHOXC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142972   
Orphanet
MedgenHOXC6
Genetic Testing Registry HOXC6
NextProtP09630 [Medical]
TSGene3223
GENETestsHOXC6
Huge Navigator HOXC6 [HugePedia]
snp3D : Map Gene to Disease3223
BioCentury BCIQHOXC6
ClinGenHOXC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3223
Chemical/Pharm GKB GenePA29403
Clinical trialHOXC6
Miscellaneous
canSAR (ICR)HOXC6 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXC6
EVEXHOXC6
GoPubMedHOXC6
iHOPHOXC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:19:20 CEST 2017

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