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HOXD11 (homeobox D11)

Identity

Alias_namesHOX4
HOX4F
homeo box D11
Other alias
HGNC (Hugo) HOXD11
LocusID (NCBI) 3237
Atlas_Id 40853
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 176107356 and ends at 176109588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AGAP3 (7q36.1) / HOXD11 (2q31.1)HOXD11 (2q31.1) / HOXD10 (2q31.1)HOXD11 (2q31.1) / NUP98 (11p15.4)
NUP98 (11p15.4) / HOXD11 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;11)(q23;p15) NUP98/PRRX1
t(2;11)(q31;p15) NUP98/HOXD13::t(2;11)(q31;p15) NUP98/HOXD11


External links

Nomenclature
HGNC (Hugo)HOXD11   5134
Cards
Entrez_Gene (NCBI)HOXD11  3237  homeobox D11
AliasesHOX4; HOX4F
GeneCards (Weizmann)HOXD11
Ensembl hg19 (Hinxton)ENSG00000128713 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128713 [Gene_View]  chr2:176107356-176109588 [Contig_View]  HOXD11 [Vega]
ICGC DataPortalENSG00000128713
TCGA cBioPortalHOXD11
AceView (NCBI)HOXD11
Genatlas (Paris)HOXD11
WikiGenes3237
SOURCE (Princeton)HOXD11
Genetics Home Reference (NIH)HOXD11
Genomic and cartography
GoldenPath hg38 (UCSC)HOXD11  -     chr2:176107356-176109588 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXD11  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblHOXD11 - 2q31.1 [CytoView hg19]  HOXD11 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIHOXD11 [Mapview hg19]  HOXD11 [Mapview hg38]
OMIM142986   
Gene and transcription
Genbank (Entrez)AK309681 BC109394 BC160135 BE260674
RefSeq transcript (Entrez)NM_021192
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXD11
Cluster EST : UnigeneHs.421136 [ NCBI ]
CGAP (NCI)Hs.421136
Alternative Splicing GalleryENSG00000128713
Gene ExpressionHOXD11 [ NCBI-GEO ]   HOXD11 [ EBI - ARRAY_EXPRESS ]   HOXD11 [ SEEK ]   HOXD11 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXD11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3237
GTEX Portal (Tissue expression)HOXD11
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31277   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31277  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31277
Splice isoforms : SwissVarP31277
PhosPhoSitePlusP31277
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)DUF3528    Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)DUF3528 (PF12045)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam12045    pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXD11
DMDM Disease mutations3237
Blocks (Seattle)HOXD11
SuperfamilyP31277
Human Protein AtlasENSG00000128713
Peptide AtlasP31277
HPRD00869
IPIIPI00305856   IPI00784141   
Protein Interaction databases
DIP (DOE-UCLA)P31277
IntAct (EBI)P31277
FunCoupENSG00000128713
BioGRIDHOXD11
STRING (EMBL)HOXD11
ZODIACHOXD11
Ontologies - Pathways
QuickGOP31277
Ontology : AmiGObranching involved in ureteric bud morphogenesis  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  dorsal/ventral pattern formation  sequence-specific DNA binding  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  dorsal/ventral pattern formation  sequence-specific DNA binding  
NDEx NetworkHOXD11
Atlas of Cancer Signalling NetworkHOXD11
Wikipedia pathwaysHOXD11
Orthology - Evolution
OrthoDB3237
GeneTree (enSembl)ENSG00000128713
Phylogenetic Trees/Animal Genes : TreeFamHOXD11
HOVERGENP31277
HOGENOMP31277
Homologs : HomoloGeneHOXD11
Homology/Alignments : Family Browser (UCSC)HOXD11
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/HOXD11 [11p15.4/2q31.1]  [t(2;11)(q31;p15)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXD11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXD11
dbVarHOXD11
ClinVarHOXD11
1000_GenomesHOXD11 
Exome Variant ServerHOXD11
ExAC (Exome Aggregation Consortium)HOXD11 (select the gene name)
Genetic variants : HAPMAP3237
Genomic Variants (DGV)HOXD11 [DGVbeta]
DECIPHERHOXD11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXD11 
Mutations
ICGC Data PortalHOXD11 
TCGA Data PortalHOXD11 
Broad Tumor PortalHOXD11
OASIS PortalHOXD11 [ Somatic mutations - Copy number]
Cancer Gene: CensusHOXD11 
Mutations and Diseases : HGMDHOXD11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HOXD11
DgiDB (Drug Gene Interaction Database)HOXD11
DoCM (Curated mutations)HOXD11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXD11 (select a term)
intoGenHOXD11
Cancer3DHOXD11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142986   
Orphanet
MedgenHOXD11
Genetic Testing Registry HOXD11
NextProtP31277 [Medical]
TSGene3237
GENETestsHOXD11
Target ValidationHOXD11
Huge Navigator HOXD11 [HugePedia]
snp3D : Map Gene to Disease3237
BioCentury BCIQHOXD11
ClinGenHOXD11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3237
Chemical/Pharm GKB GenePA29408
Clinical trialHOXD11
Miscellaneous
canSAR (ICR)HOXD11 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXD11
EVEXHOXD11
GoPubMedHOXD11
iHOPHOXD11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:37:22 CEST 2017

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