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HOXD8 (homeobox D8)

Identity

Other aliasHOX4
HOX4E
HOX5.4
HGNC (Hugo) HOXD8
LocusID (NCBI) 3234
Atlas_Id 56821
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 176129740 and ends at 176132695 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HOXD8   5139
Cards
Entrez_Gene (NCBI)HOXD8  3234  homeobox D8
AliasesHOX4; HOX4E; HOX5.4
GeneCards (Weizmann)HOXD8
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:176129740-176132695 [Contig_View]  HOXD8 [Vega]
TCGA cBioPortalHOXD8
AceView (NCBI)HOXD8
Genatlas (Paris)HOXD8
WikiGenes3234
SOURCE (Princeton)HOXD8
Genetics Home Reference (NIH)HOXD8
Genomic and cartography
GoldenPath hg38 (UCSC)HOXD8  -     chr2:176129740-176132695 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HOXD8  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblHOXD8 - 2q31.1 [CytoView hg19]  HOXD8 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIHOXD8 [Mapview hg19]  HOXD8 [Mapview hg38]
OMIM142985   
Gene and transcription
Genbank (Entrez)AL530925 AW140108 BC038709 BC090853 BI764317
RefSeq transcript (Entrez)NM_001199746 NM_001199747 NM_019558
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HOXD8
Cluster EST : UnigeneHs.700870 [ NCBI ]
CGAP (NCI)Hs.700870
Gene ExpressionHOXD8 [ NCBI-GEO ]   HOXD8 [ EBI - ARRAY_EXPRESS ]   HOXD8 [ SEEK ]   HOXD8 [ MEM ]
Gene Expression Viewer (FireBrowse)HOXD8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3234
GTEX Portal (Tissue expression)HOXD8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13378   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13378  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13378
Splice isoforms : SwissVarP13378
PhosPhoSitePlusP13378
Domaine pattern : Prosite (Expaxy)ANTENNAPEDIA (PS00032)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_Antennapedia_CS    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HOXD8
DMDM Disease mutations3234
Blocks (Seattle)HOXD8
SuperfamilyP13378
Peptide AtlasP13378
IPIIPI00008481   IPI01018181   IPI00916034   
Protein Interaction databases
DIP (DOE-UCLA)P13378
IntAct (EBI)P13378
BioGRIDHOXD8
STRING (EMBL)HOXD8
ZODIACHOXD8
Ontologies - Pathways
QuickGOP13378
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  nucleus  transcription from RNA polymerase II promoter  anterior/posterior axis specification, embryo  positive regulation of transcription from RNA polymerase II promoter  skeletal system morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  nucleus  transcription from RNA polymerase II promoter  anterior/posterior axis specification, embryo  positive regulation of transcription from RNA polymerase II promoter  skeletal system morphogenesis  
NDEx NetworkHOXD8
Atlas of Cancer Signalling NetworkHOXD8
Wikipedia pathwaysHOXD8
Orthology - Evolution
OrthoDB3234
Phylogenetic Trees/Animal Genes : TreeFamHOXD8
HOVERGENP13378
HOGENOMP13378
Homologs : HomoloGeneHOXD8
Homology/Alignments : Family Browser (UCSC)HOXD8
Gene fusions - Rearrangements
Tumor Fusion PortalHOXD8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHOXD8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HOXD8
dbVarHOXD8
ClinVarHOXD8
1000_GenomesHOXD8 
Exome Variant ServerHOXD8
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP3234
Genomic Variants (DGV)HOXD8 [DGVbeta]
DECIPHERHOXD8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHOXD8 
Mutations
ICGC Data PortalHOXD8 
TCGA Data PortalHOXD8 
Broad Tumor PortalHOXD8
OASIS PortalHOXD8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHOXD8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHOXD8
BioMutasearch HOXD8
DgiDB (Drug Gene Interaction Database)HOXD8
DoCM (Curated mutations)HOXD8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HOXD8 (select a term)
intoGenHOXD8
Cancer3DHOXD8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142985   
Orphanet
DisGeNETHOXD8
MedgenHOXD8
Genetic Testing Registry HOXD8
NextProtP13378 [Medical]
TSGene3234
GENETestsHOXD8
Target ValidationHOXD8
Huge Navigator HOXD8 [HugePedia]
snp3D : Map Gene to Disease3234
BioCentury BCIQHOXD8
ClinGenHOXD8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3234
Chemical/Pharm GKB GenePA29413
Clinical trialHOXD8
Miscellaneous
canSAR (ICR)HOXD8 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHOXD8
EVEXHOXD8
GoPubMedHOXD8
iHOPHOXD8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:16:42 CET 2017

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