Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HP (haptoglobin)

Identity

Other aliasBP
HP2ALPHA2
HPA1S
HGNC (Hugo) HP
LocusID (NCBI) 3240
Atlas_Id 45677
Location 16q22.2  [Link to chromosome band 16q22]
Location_base_pair Starts at 72054592 and ends at 72061056 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HP (16q22.2) / HP (16q22.2)HP (16q22.2) / MRPS10 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HP   5141
Cards
Entrez_Gene (NCBI)HP  3240  haptoglobin
AliasesBP; HP2ALPHA2; HPA1S
GeneCards (Weizmann)HP
Ensembl hg19 (Hinxton)ENSG00000257017 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000257017 [Gene_View]  chr16:72054592-72061056 [Contig_View]  HP [Vega]
ICGC DataPortalENSG00000257017
TCGA cBioPortalHP
AceView (NCBI)HP
Genatlas (Paris)HP
WikiGenes3240
SOURCE (Princeton)HP
Genetics Home Reference (NIH)HP
Genomic and cartography
GoldenPath hg38 (UCSC)HP  -     chr16:72054592-72061056 +  16q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HP  -     16q22.2   [Description]    (hg19-Feb_2009)
EnsemblHP - 16q22.2 [CytoView hg19]  HP - 16q22.2 [CytoView hg38]
Mapping of homologs : NCBIHP [Mapview hg19]  HP [Mapview hg38]
OMIM140100   614081   
Gene and transcription
Genbank (Entrez)AK055872 AK314700 BC017862 BC058031 BC070299
RefSeq transcript (Entrez)NM_001126102 NM_001318138 NM_005143
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HP
Cluster EST : UnigeneHs.702099 [ NCBI ]
CGAP (NCI)Hs.702099
Alternative Splicing GalleryENSG00000257017
Gene ExpressionHP [ NCBI-GEO ]   HP [ EBI - ARRAY_EXPRESS ]   HP [ SEEK ]   HP [ MEM ]
Gene Expression Viewer (FireBrowse)HP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3240
GTEX Portal (Tissue expression)HP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00738   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00738  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00738
Splice isoforms : SwissVarP00738
PhosPhoSitePlusP00738
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)    TRYPSIN_DOM (PS50240)   
Domains : Interpro (EBI)Haptoglobin    Peptidase_S1_PA    Peptidase_S1A    Sushi_SCR_CCP_dom    Trypsin_dom   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)HP
DMDM Disease mutations3240
Blocks (Seattle)HP
PDB (SRS)4WJG    4X0L    5HU6   
PDB (PDBSum)4WJG    4X0L    5HU6   
PDB (IMB)4WJG    4X0L    5HU6   
PDB (RSDB)4WJG    4X0L    5HU6   
Structural Biology KnowledgeBase4WJG    4X0L    5HU6   
SCOP (Structural Classification of Proteins)4WJG    4X0L    5HU6   
CATH (Classification of proteins structures)4WJG    4X0L    5HU6   
SuperfamilyP00738
Human Protein AtlasENSG00000257017
Peptide AtlasP00738
HPRD00772
Protein Interaction databases
DIP (DOE-UCLA)P00738
IntAct (EBI)P00738
FunCoupENSG00000257017
BioGRIDHP
STRING (EMBL)HP
ZODIACHP
Ontologies - Pathways
QuickGOP00738
Ontology : AmiGOprotein binding  extracellular region  extracellular region  extracellular space  receptor-mediated endocytosis  defense response  acute-phase response  positive regulation of cell death  antioxidant activity  hemoglobin binding  haptoglobin-hemoglobin complex  specific granule lumen  response to hydrogen peroxide  defense response to bacterium  neutrophil degranulation  negative regulation of oxidoreductase activity  extracellular exosome  endocytic vesicle lumen  blood microparticle  cellular oxidant detoxification  tertiary granule lumen  negative regulation of hydrogen peroxide catabolic process  
Ontology : EGO-EBIprotein binding  extracellular region  extracellular region  extracellular space  receptor-mediated endocytosis  defense response  acute-phase response  positive regulation of cell death  antioxidant activity  hemoglobin binding  haptoglobin-hemoglobin complex  specific granule lumen  response to hydrogen peroxide  defense response to bacterium  neutrophil degranulation  negative regulation of oxidoreductase activity  extracellular exosome  endocytic vesicle lumen  blood microparticle  cellular oxidant detoxification  tertiary granule lumen  negative regulation of hydrogen peroxide catabolic process  
NDEx NetworkHP
Atlas of Cancer Signalling NetworkHP
Wikipedia pathwaysHP
Orthology - Evolution
OrthoDB3240
GeneTree (enSembl)ENSG00000257017
Phylogenetic Trees/Animal Genes : TreeFamHP
HOVERGENP00738
HOGENOMP00738
Homologs : HomoloGeneHP
Homology/Alignments : Family Browser (UCSC)HP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HP
dbVarHP
ClinVarHP
1000_GenomesHP 
Exome Variant ServerHP
ExAC (Exome Aggregation Consortium)HP (select the gene name)
Genetic variants : HAPMAP3240
Genomic Variants (DGV)HP [DGVbeta]
DECIPHERHP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHP 
Mutations
ICGC Data PortalHP 
TCGA Data PortalHP 
Broad Tumor PortalHP
OASIS PortalHP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HP
DgiDB (Drug Gene Interaction Database)HP
DoCM (Curated mutations)HP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HP (select a term)
intoGenHP
Cancer3DHP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140100    614081   
Orphanet
MedgenHP
Genetic Testing Registry HP
NextProtP00738 [Medical]
TSGene3240
GENETestsHP
Target ValidationHP
Huge Navigator HP [HugePedia]
snp3D : Map Gene to Disease3240
BioCentury BCIQHP
ClinGenHP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3240
Chemical/Pharm GKB GenePA29415
Clinical trialHP
Miscellaneous
canSAR (ICR)HP (select the gene name)
Probes
Litterature
PubMed324 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHP
EVEXHP
GoPubMedHP
iHOPHP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:20 CEST 2017

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