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HP1BP3 (heterochromatin protein 1 binding protein 3)

Identity

Alias_namesheterochromatin protein 1, binding protein 3
Alias_symbol (synonym)HP1-BP74
Other aliasHP1BP74
HGNC (Hugo) HP1BP3
LocusID (NCBI) 50809
Atlas_Id 55344
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 20742678 and ends at 20786688 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HP1BP3 (1p36.12) / HP1BP3 (1p36.12)HP1BP3 (1p36.12) / HSPA5 (9q33.3)HP1BP3 (1p36.12) / TMCO4 (1p36.13)
IFFO2 (1p36.13) / HP1BP3 (1p36.12)KDM4B (19p13.3) / HP1BP3 (1p36.12)SLCO1A2 (12p12.1) / HP1BP3 (1p36.12)
ZNF791 (19p13.2) / HP1BP3 (1p36.12)HP1BP3 1p36.12 / TMCO4 1p36.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  HP1BP3/TMCO4 (1p36)

External links

Nomenclature
HGNC (Hugo)HP1BP3   24973
Cards
Entrez_Gene (NCBI)HP1BP3  50809  heterochromatin protein 1 binding protein 3
AliasesHP1-BP74; HP1BP74
GeneCards (Weizmann)HP1BP3
Ensembl hg19 (Hinxton)ENSG00000127483 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127483 [Gene_View]  ENSG00000127483 [Sequence]  chr1:20742678-20786688 [Contig_View]  HP1BP3 [Vega]
ICGC DataPortalENSG00000127483
TCGA cBioPortalHP1BP3
AceView (NCBI)HP1BP3
Genatlas (Paris)HP1BP3
WikiGenes50809
SOURCE (Princeton)HP1BP3
Genetics Home Reference (NIH)HP1BP3
Genomic and cartography
GoldenPath hg38 (UCSC)HP1BP3  -     chr1:20742678-20786688 -  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HP1BP3  -     1p36.12   [Description]    (hg19-Feb_2009)
GoldenPathHP1BP3 - 1p36.12 [CytoView hg19]  HP1BP3 - 1p36.12 [CytoView hg38]
ImmunoBaseENSG00000127483
Mapping of homologs : NCBIHP1BP3 [Mapview hg19]  HP1BP3 [Mapview hg38]
OMIM616072   
Gene and transcription
Genbank (Entrez)AF113534 AK023129 AK025754 AK291252 AK303456
RefSeq transcript (Entrez)NM_001372052 NM_016287
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HP1BP3
Cluster EST : UnigeneHs.142442 [ NCBI ]
CGAP (NCI)Hs.142442
Alternative Splicing GalleryENSG00000127483
Gene ExpressionHP1BP3 [ NCBI-GEO ]   HP1BP3 [ EBI - ARRAY_EXPRESS ]   HP1BP3 [ SEEK ]   HP1BP3 [ MEM ]
Gene Expression Viewer (FireBrowse)HP1BP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50809
GTEX Portal (Tissue expression)HP1BP3
Human Protein AtlasENSG00000127483-HP1BP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5SSJ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5SSJ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5SSJ5
Splice isoforms : SwissVarQ5SSJ5
PhosPhoSitePlusQ5SSJ5
Domaine pattern : Prosite (Expaxy)H15 (PS51504)   
Domains : Interpro (EBI)Histone_H1/H5_H15    HP1BP3    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Linker_histone (PF00538)   
Domain families : Pfam (NCBI)pfam00538   
Domain families : Smart (EMBL)H15 (SM00526)  
Conserved Domain (NCBI)HP1BP3
DMDM Disease mutations50809
Blocks (Seattle)HP1BP3
PDB (RSDB)2RQP   
PDB Europe2RQP   
PDB (PDBSum)2RQP   
PDB (IMB)2RQP   
Structural Biology KnowledgeBase2RQP   
SCOP (Structural Classification of Proteins)2RQP   
CATH (Classification of proteins structures)2RQP   
SuperfamilyQ5SSJ5
Human Protein Atlas [tissue]ENSG00000127483-HP1BP3 [tissue]
Peptide AtlasQ5SSJ5
HPRD11026
IPIIPI00642238   IPI00646486   IPI00871239   IPI00448752   IPI00980952   IPI00640417   IPI00877866   IPI00878331   IPI00878182   IPI00878648   IPI00744429   IPI00878947   
Protein Interaction databases
DIP (DOE-UCLA)Q5SSJ5
IntAct (EBI)Q5SSJ5
FunCoupENSG00000127483
BioGRIDHP1BP3
STRING (EMBL)HP1BP3
ZODIACHP1BP3
Ontologies - Pathways
QuickGOQ5SSJ5
Ontology : AmiGOnucleosome  DNA binding  protein binding  nucleus  chromosome  nucleosome assembly  regulation of transcription, DNA-templated  nuclear speck  nucleosome binding  regulation of cell proliferation  heterochromatin organization  cellular response to hypoxia  regulation of nucleus size  
Ontology : EGO-EBInucleosome  DNA binding  protein binding  nucleus  chromosome  nucleosome assembly  regulation of transcription, DNA-templated  nuclear speck  nucleosome binding  regulation of cell proliferation  heterochromatin organization  cellular response to hypoxia  regulation of nucleus size  
NDEx NetworkHP1BP3
Atlas of Cancer Signalling NetworkHP1BP3
Wikipedia pathwaysHP1BP3
Orthology - Evolution
OrthoDB50809
GeneTree (enSembl)ENSG00000127483
Phylogenetic Trees/Animal Genes : TreeFamHP1BP3
HOGENOMQ5SSJ5
Homologs : HomoloGeneHP1BP3
Homology/Alignments : Family Browser (UCSC)HP1BP3
Gene fusions - Rearrangements
Fusion : MitelmanHP1BP3/TMCO4 [1p36.12/1p36.13]  
Fusion PortalHP1BP3 1p36.12 TMCO4 1p36.13 LGG
Fusion : QuiverHP1BP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHP1BP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HP1BP3
dbVarHP1BP3
ClinVarHP1BP3
1000_GenomesHP1BP3 
Exome Variant ServerHP1BP3
ExAC (Exome Aggregation Consortium)ENSG00000127483
GNOMAD BrowserENSG00000127483
Varsome BrowserHP1BP3
Genetic variants : HAPMAP50809
Genomic Variants (DGV)HP1BP3 [DGVbeta]
DECIPHERHP1BP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHP1BP3 
Mutations
ICGC Data PortalHP1BP3 
TCGA Data PortalHP1BP3 
Broad Tumor PortalHP1BP3
OASIS PortalHP1BP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHP1BP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHP1BP3
Mutations and Diseases : HGMDHP1BP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HP1BP3
DgiDB (Drug Gene Interaction Database)HP1BP3
DoCM (Curated mutations)HP1BP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HP1BP3 (select a term)
intoGenHP1BP3
Cancer3DHP1BP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616072   
Orphanet
DisGeNETHP1BP3
MedgenHP1BP3
Genetic Testing Registry HP1BP3
NextProtQ5SSJ5 [Medical]
TSGene50809
GENETestsHP1BP3
Target ValidationHP1BP3
Huge Navigator HP1BP3 [HugePedia]
snp3D : Map Gene to Disease50809
BioCentury BCIQHP1BP3
ClinGenHP1BP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50809
Chemical/Pharm GKB GenePA142671673
Clinical trialHP1BP3
Miscellaneous
canSAR (ICR)HP1BP3 (select the gene name)
DataMed IndexHP1BP3
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHP1BP3
EVEXHP1BP3
GoPubMedHP1BP3
iHOPHP1BP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:47:14 CET 2019
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