HPGD (15-hydroxyprostaglandin dehydrogenase)

2007-02-01  

Identity

HGNC
HPGD
LOCATION
4q34.1
LOCUSID
3248
ALIAS
15-PGDH,PGDH,PGDH1,PHOAR1,SDR36C1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3248
MIM: 601688
HGNC: 5154
Ensembl: ENSG00000164120

Variants:

dbSNP: 3248
ClinVar: 3248
TCGA: ENSG00000164120
COSMIC: HPGD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164120ENST00000296521P15428
ENSG00000164120ENST00000296522P15428
ENSG00000164120ENST00000422112P15428
ENSG00000164120ENST00000504433E9PBZ2
ENSG00000164120ENST00000506910D6RA83
ENSG00000164120ENST00000508330E9PD69
ENSG00000164120ENST00000510835D6RHF8
ENSG00000164120ENST00000510901P15428
ENSG00000164120ENST00000514584D6RA66
ENSG00000164120ENST00000541923P15428
ENSG00000164120ENST00000542498P15428

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Synthesis of Lipoxins (LX)REACTOMER-HSA-2142700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
16880406200615-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.104
15574495200415-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.87
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
260688572015TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.67
185003422008Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.54
247601902014Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).40
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
19584167200915-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.31
200934792010Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.31
212817862011Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer.31

Citation

Dessen P

HPGD (15-hydroxyprostaglandin dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43840/hpgd