Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HPGD (15-hydroxyprostaglandin dehydrogenase)

Identity

Alias (NCBI)15-PGDH
PGDH
PGDH1
PHOAR1
SDR36C1
HGNC (Hugo) HPGD
HGNC Alias symbSDR36C1
HGNC Alias nameshort chain dehydrogenase/reductase family 36C, member 1
 15-hydroxyprostaglandin dehydrogenase (NAD(+))
HGNC Previous namehydroxyprostaglandin dehydrogenase 15-(NAD)
LocusID (NCBI) 3248
Atlas_Id 43840
Location 4q34.1  [Link to chromosome band 4q34]
Location_base_pair Starts at 174506743 and ends at 174522488 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSPT1 (16p13.13) / HPGD (4q34.1)HPGD (4q34.1) / HPGD (4q34.1)MIR100HG (11q24.1) / HPGD (4q34.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HPGD   5154
Cards
Entrez_Gene (NCBI)HPGD    15-hydroxyprostaglandin dehydrogenase
Aliases15-PGDH; PGDH; PGDH1; PHOAR1; 
SDR36C1
GeneCards (Weizmann)HPGD
Ensembl hg19 (Hinxton)ENSG00000164120 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164120 [Gene_View]  ENSG00000164120 [Sequence]  chr4:174506743-174522488 [Contig_View]  HPGD [Vega]
ICGC DataPortalENSG00000164120
TCGA cBioPortalHPGD
AceView (NCBI)HPGD
Genatlas (Paris)HPGD
SOURCE (Princeton)HPGD
Genetics Home Reference (NIH)HPGD
Genomic and cartography
GoldenPath hg38 (UCSC)HPGD  -     chr4:174506743-174522488 -  4q34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HPGD  -     4q34.1   [Description]    (hg19-Feb_2009)
GoldenPathHPGD - 4q34.1 [CytoView hg19]  HPGD - 4q34.1 [CytoView hg38]
ImmunoBaseENSG00000164120
Genome Data Viewer NCBIHPGD [Mapview hg19]  
OMIM119900   259100   601688   
Gene and transcription
Genbank (Entrez)AI435471 AK058013 AK296642 AK300125 AK300524
RefSeq transcript (Entrez)NM_000860 NM_001145816 NM_001256301 NM_001256305 NM_001256306 NM_001256307 NM_001363574
Consensus coding sequences : CCDS (NCBI)HPGD
Gene ExpressionHPGD [ NCBI-GEO ]   HPGD [ EBI - ARRAY_EXPRESS ]   HPGD [ SEEK ]   HPGD [ MEM ]
Gene Expression Viewer (FireBrowse)HPGD [ Firebrowse - Broad ]
GenevisibleExpression of HPGD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3248
GTEX Portal (Tissue expression)HPGD
Human Protein AtlasENSG00000164120-HPGD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15428   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15428  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15428
PhosPhoSitePlusP15428
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)NAD(P)-bd_dom_sf    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
Conserved Domain (NCBI)HPGD
PDB (RSDB)2GDZ   
PDB Europe2GDZ   
PDB (PDBSum)2GDZ   
PDB (IMB)2GDZ   
Structural Biology KnowledgeBase2GDZ   
SCOP (Structural Classification of Proteins)2GDZ   
CATH (Classification of proteins structures)2GDZ   
SuperfamilyP15428
AlphaFold pdb e-kbP15428   
Human Protein Atlas [tissue]ENSG00000164120-HPGD [tissue]
HPRD03406
Protein Interaction databases
DIP (DOE-UCLA)P15428
IntAct (EBI)P15428
BioGRIDHPGD
STRING (EMBL)HPGD
ZODIACHPGD
Ontologies - Pathways
QuickGOP15428
Ontology : AmiGOkidney development  prostaglandin E receptor activity  nucleoplasm  cytoplasm  cytosol  cytosol  cytosol  prostaglandin metabolic process  prostaglandin metabolic process  transforming growth factor beta receptor signaling pathway  female pregnancy  female pregnancy  parturition  basolateral plasma membrane  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  lipoxygenase pathway  ovulation  response to estradiol  response to lipopolysaccharide  long-chain fatty acid biosynthetic process  identical protein binding  positive regulation of apoptotic process  response to ethanol  negative regulation of cell cycle  NAD binding  extracellular exosome  NAD+ binding  thrombin-activated receptor signaling pathway  ductus arteriosus closure  positive regulation of vascular associated smooth muscle cell proliferation  regulation of prostaglandin catabolic process  lipoxin biosynthetic process  
Ontology : EGO-EBIkidney development  prostaglandin E receptor activity  nucleoplasm  cytoplasm  cytosol  cytosol  cytosol  prostaglandin metabolic process  prostaglandin metabolic process  transforming growth factor beta receptor signaling pathway  female pregnancy  female pregnancy  parturition  basolateral plasma membrane  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  lipoxygenase pathway  ovulation  response to estradiol  response to lipopolysaccharide  long-chain fatty acid biosynthetic process  identical protein binding  positive regulation of apoptotic process  response to ethanol  negative regulation of cell cycle  NAD binding  extracellular exosome  NAD+ binding  thrombin-activated receptor signaling pathway  ductus arteriosus closure  positive regulation of vascular associated smooth muscle cell proliferation  regulation of prostaglandin catabolic process  lipoxin biosynthetic process  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkHPGD
Atlas of Cancer Signalling NetworkHPGD
Wikipedia pathwaysHPGD
Orthology - Evolution
OrthoDB3248
GeneTree (enSembl)ENSG00000164120
Phylogenetic Trees/Animal Genes : TreeFamHPGD
Homologs : HomoloGeneHPGD
Homology/Alignments : Family Browser (UCSC)HPGD
Gene fusions - Rearrangements
Fusion : QuiverHPGD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHPGD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HPGD
dbVarHPGD
ClinVarHPGD
MonarchHPGD
1000_GenomesHPGD 
Exome Variant ServerHPGD
GNOMAD BrowserENSG00000164120
Varsome BrowserHPGD
ACMGHPGD variants
VarityP15428
Genomic Variants (DGV)HPGD [DGVbeta]
DECIPHERHPGD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHPGD 
Mutations
ICGC Data PortalHPGD 
TCGA Data PortalHPGD 
Broad Tumor PortalHPGD
OASIS PortalHPGD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHPGD  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHPGD
Mutations and Diseases : HGMDHPGD
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHPGD
DgiDB (Drug Gene Interaction Database)HPGD
DoCM (Curated mutations)HPGD
CIViC (Clinical Interpretations of Variants in Cancer)HPGD
Cancer3DHPGD
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM119900    259100    601688   
Orphanet1691    2542    18818   
DisGeNETHPGD
MedgenHPGD
Genetic Testing Registry HPGD
NextProtP15428 [Medical]
GENETestsHPGD
Target ValidationHPGD
Huge Navigator HPGD [HugePedia]
ClinGenHPGD
Clinical trials, drugs, therapy
MyCancerGenomeHPGD
Protein Interactions : CTDHPGD
Pharm GKB GenePA29424
PharosP15428
Clinical trialHPGD
Miscellaneous
canSAR (ICR)HPGD
HarmonizomeHPGD
DataMed IndexHPGD
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHPGD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:12:55 CEST 2021

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