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HPGD (hydroxyprostaglandin dehydrogenase 15-(NAD))

Identity

Other names15-PGDH
PGDH
PGDH1
PHOAR1
SDR36C1
HGNC (Hugo) HPGD
LocusID (NCBI) 3248
Location 4q34.1
Location_base_pair Starts at 175411328 and ends at 175444049 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HPGD   5154
Cards
Entrez_Gene (NCBI)HPGD  3248  hydroxyprostaglandin dehydrogenase 15-(NAD)
GeneCards (Weizmann)HPGD
Ensembl (Hinxton)ENSG00000164120 [Gene_View]  chr4:175411328-175444049 [Contig_View]  HPGD [Vega]
ICGC DataPortalENSG00000164120
cBioPortalHPGD
AceView (NCBI)HPGD
Genatlas (Paris)HPGD
WikiGenes3248
SOURCE (Princeton)NM_000860 NM_001145816 NM_001256301 NM_001256305 NM_001256306 NM_001256307
Genomic and cartography
GoldenPath (UCSC)HPGD  -  4q34.1   chr4:175411328-175444049 -  4q34.1   [Description]    (hg19-Feb_2009)
EnsemblHPGD - 4q34.1 [CytoView]
Mapping of homologs : NCBIHPGD [Mapview]
OMIM119900   259100   601688   
Gene and transcription
Genbank (Entrez)AI435471 AK058013 AK296642 AK300125 AK300524
RefSeq transcript (Entrez)NM_000860 NM_001145816 NM_001256301 NM_001256305 NM_001256306 NM_001256307
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_011689 NT_016354 NW_001838921 NW_004929320
Consensus coding sequences : CCDS (NCBI)HPGD
Cluster EST : UnigeneHs.596913 [ NCBI ]
CGAP (NCI)Hs.596913
Alternative Splicing : Fast-db (Paris)GSHG0023659
Alternative Splicing GalleryENSG00000164120
Gene ExpressionHPGD [ NCBI-GEO ]     HPGD [ SEEK ]   HPGD [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15428 (Uniprot)
NextProtP15428  [Medical]
With graphics : InterProP15428
Splice isoforms : SwissVarP15428 (Swissvar)
Catalytic activity : Enzyme1.1.1.141 [ Enzyme-Expasy ]   1.1.1.1411.1.1.141 [ IntEnz-EBI ]   1.1.1.141 [ BRENDA ]   1.1.1.141 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)DH_sc/Rdtase_SDR [organisation]   Glc/ribitol_DH [organisation]   NAD(P)-bd_dom [organisation]   Sc_DH/Rdtase_CS [organisation]  
Related proteins : CluSTrP15428
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
DMDM Disease mutations3248
Blocks (Seattle)P15428
PDB (SRS)2GDZ   
PDB (PDBSum)2GDZ   
PDB (IMB)2GDZ   
PDB (RSDB)2GDZ   
Human Protein AtlasENSG00000164120 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP15428
HPRD03406
IPIIPI00305286   IPI00966984   IPI00965509   IPI00964054   IPI00967930   IPI00965021   IPI00965302   IPI00910658   IPI00290420   
Protein Interaction databases
DIP (DOE-UCLA)P15428
IntAct (EBI)P15428
FunCoupENSG00000164120
BioGRIDHPGD
InParanoidP15428
Interologous Interaction database P15428
IntegromeDBHPGD
STRING (EMBL)HPGD
Ontologies - Pathways
Ontology : AmiGOcatalytic activity  prostaglandin E receptor activity  cytosol  cytosol  prostaglandin metabolic process  transforming growth factor beta receptor signaling pathway  female pregnancy  parturition  basolateral plasma membrane  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  arachidonic acid metabolic process  cyclooxygenase pathway  lipoxygenase pathway  ovulation  protein homodimerization activity  small molecule metabolic process  negative regulation of cell cycle  NAD binding  oxidation-reduction process  extracellular vesicular exosome  NAD+ binding  thrombin receptor signaling pathway  ductus arteriosus closure  lipoxin metabolic process  
Ontology : EGO-EBIcatalytic activity  prostaglandin E receptor activity  cytosol  cytosol  prostaglandin metabolic process  transforming growth factor beta receptor signaling pathway  female pregnancy  parturition  basolateral plasma membrane  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  15-hydroxyprostaglandin dehydrogenase (NAD+) activity  arachidonic acid metabolic process  cyclooxygenase pathway  lipoxygenase pathway  ovulation  protein homodimerization activity  small molecule metabolic process  negative regulation of cell cycle  NAD binding  oxidation-reduction process  extracellular vesicular exosome  NAD+ binding  thrombin receptor signaling pathway  ductus arteriosus closure  lipoxin metabolic process  
Pathways : KEGGTranscriptional misregulation in cancer   
Protein Interaction DatabaseHPGD
Wikipedia pathwaysHPGD
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HPGD
snp3D : Map Gene to Disease3248
SNP (GeneSNP Utah)HPGD
SNP : HGBaseHPGD
Genetic variants : HAPMAPHPGD
Exome VariantHPGD
1000_GenomesHPGD 
ICGC programENSG00000164120 
Somatic Mutations in Cancer : COSMICHPGD 
CONAN: Copy Number AnalysisHPGD 
Mutations and Diseases : HGMDHPGD
Mutations and Diseases : intOGenHPGD
Genomic VariantsHPGD  HPGD [DGVbeta]
dbVarHPGD
ClinVarHPGD
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM119900    259100    601688   
MedgenHPGD
GENETestsHPGD
Disease Genetic AssociationHPGD
Huge Navigator HPGD [HugePedia]  HPGD [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneHPGD
Homology/Alignments : Family Browser (UCSC)HPGD
Phylogenetic Trees/Animal Genes : TreeFamHPGD
Chemical/Protein Interactions : CTD3248
Chemical/Pharm GKB GenePA29424
Clinical trialHPGD
Cancer Resource (Charite)ENSG00000164120
Other databases
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
CoreMineHPGD
iHOPHPGD
OncoSearchHPGD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:49:56 CEST 2014

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