Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HPSE (heparanase)

Identity

Other namesHPA
HPA1
HPR1
HPSE1
HSE1
HGNC (Hugo) HPSE
LocusID (NCBI) 10855
Location 4q21.23
Location_base_pair Starts at 84213614 and ends at 84256034 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HPSE   5164
Cards
Entrez_Gene (NCBI)HPSE  10855  heparanase
GeneCards (Weizmann)HPSE
Ensembl hg19 (Hinxton)ENSG00000173083 [Gene_View]  chr4:84213614-84256034 [Contig_View]  HPSE [Vega]
Ensembl hg38 (Hinxton)ENSG00000173083 [Gene_View]  chr4:84213614-84256034 [Contig_View]  HPSE [Vega]
ICGC DataPortalENSG00000173083
cBioPortalHPSE
AceView (NCBI)HPSE
Genatlas (Paris)HPSE
WikiGenes10855
SOURCE (Princeton)HPSE
Genomic and cartography
GoldenPath hg19 (UCSC)HPSE  -     chr4:84213614-84256034 -  4q21.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HPSE  -     4q21.23   [Description]    (hg38-Dec_2013)
EnsemblHPSE - 4q21.23 [CytoView hg19]  HPSE - 4q21.23 [CytoView hg38]
Mapping of homologs : NCBIHPSE [Mapview hg19]  HPSE [Mapview hg38]
OMIM604724   
Gene and transcription
Genbank (Entrez)AF084467 AF144325 AF152376 AF155510 AF165154
RefSeq transcript (Entrez)NM_001098540 NM_001166498 NM_001199830 NM_006665
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_028037 NT_016354 NW_001838915 NW_004929320
Consensus coding sequences : CCDS (NCBI)HPSE
Cluster EST : UnigeneHs.44227 [ NCBI ]
CGAP (NCI)Hs.44227
Alternative Splicing : Fast-db (Paris)GSHG0023374
Alternative Splicing GalleryENSG00000173083
Gene ExpressionHPSE [ NCBI-GEO ]     HPSE [ SEEK ]   HPSE [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y251 (Uniprot)
NextProtQ9Y251  [Medical]
With graphics : InterProQ9Y251
Splice isoforms : SwissVarQ9Y251 (Swissvar)
Catalytic activity : Enzyme3.2.1.166 [ Enzyme-Expasy ]   3.2.1.1663.2.1.166 [ IntEnz-EBI ]   3.2.1.166 [ BRENDA ]   3.2.1.166 [ KEGG ]   
Domains : Interpro (EBI)Glyco_hydro_79    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF   
Related proteins : CluSTrQ9Y251
Domain families : Pfam (Sanger)Glyco_hydro_79n (PF03662)   
Domain families : Pfam (NCBI)pfam03662   
DMDM Disease mutations10855
Blocks (Seattle)Q9Y251
Human Protein AtlasENSG00000173083
Peptide AtlasQ9Y251
HPRD05286
IPIIPI00410297   IPI01009943   IPI00884403   IPI00966332   IPI00944522   IPI00966531   IPI00967976   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y251
IntAct (EBI)Q9Y251
FunCoupENSG00000173083
BioGRIDHPSE
IntegromeDBHPSE
STRING (EMBL)HPSE
Ontologies - Pathways
QuickGOQ9Y251
Ontology : AmiGObeta-glucuronidase activity  protein binding  extracellular region  nucleus  nucleolus  lysosome  lysosomal membrane  carbohydrate metabolic process  glycosaminoglycan catabolic process  proteoglycan metabolic process  cell-matrix adhesion  positive regulation vascular endothelial growth factor production  positive regulation of blood coagulation  heparan sulfate proteoglycan catabolic process  glycosaminoglycan metabolic process  heparanase activity  heparanase activity  positive regulation of osteoblast proliferation  lysosomal lumen  intracellular membrane-bounded organelle  small molecule metabolic process  membrane raft  syndecan binding  protein dimerization activity  regulation of hair follicle development  positive regulation of hair follicle development  positive regulation of protein kinase B signaling  vascular wound healing  
Ontology : EGO-EBIbeta-glucuronidase activity  protein binding  extracellular region  nucleus  nucleolus  lysosome  lysosomal membrane  carbohydrate metabolic process  glycosaminoglycan catabolic process  proteoglycan metabolic process  cell-matrix adhesion  positive regulation vascular endothelial growth factor production  positive regulation of blood coagulation  heparan sulfate proteoglycan catabolic process  glycosaminoglycan metabolic process  heparanase activity  heparanase activity  positive regulation of osteoblast proliferation  lysosomal lumen  intracellular membrane-bounded organelle  small molecule metabolic process  membrane raft  syndecan binding  protein dimerization activity  regulation of hair follicle development  positive regulation of hair follicle development  positive regulation of protein kinase B signaling  vascular wound healing  
Pathways : KEGGGlycosaminoglycan degradation    Proteoglycans in cancer   
Protein Interaction DatabaseHPSE
DoCM (Curated mutations)HPSE
Wikipedia pathwaysHPSE
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerHPSE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HPSE
dbVarHPSE
ClinVarHPSE
1000_GenomesHPSE 
Exome Variant ServerHPSE
SNP (GeneSNP Utah)HPSE
SNP : HGBaseHPSE
Genetic variants : HAPMAPHPSE
Genomic VariantsHPSE  HPSE [DGVbeta]
Mutations
ICGC Data PortalENSG00000173083 
Somatic Mutations in Cancer : COSMICHPSE 
CONAN: Copy Number AnalysisHPSE 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:84213614-84256034
Mutations and Diseases : HGMDHPSE
OMIM604724   
MedgenHPSE
NextProtQ9Y251 [Medical]
GENETestsHPSE
Disease Genetic AssociationHPSE
Huge Navigator HPSE [HugePedia]  HPSE [HugeCancerGEM]
snp3D : Map Gene to Disease10855
DGIdb (Drug Gene Interaction db)HPSE
General knowledge
Homologs : HomoloGeneHPSE
Homology/Alignments : Family Browser (UCSC)HPSE
Phylogenetic Trees/Animal Genes : TreeFamHPSE
Chemical/Protein Interactions : CTD10855
Chemical/Pharm GKB GenePA29435
Clinical trialHPSE
Cancer Resource (Charite)ENSG00000173083
Other databases
Probes
Litterature
PubMed235 Pubmed reference(s) in Entrez
CoreMineHPSE
GoPubMedHPSE
iHOPHPSE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:03:40 CET 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.