Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HPSE (heparanase)

Identity

Alias (NCBI)HPA
HPA1
HPR1
HPSE1
HSE1
HGNC (Hugo) HPSE
HGNC Alias symbHPA
HSE1
HPSE1
LocusID (NCBI) 10855
Atlas_Id 40858
Location 4q21.23  [Link to chromosome band 4q21]
Location_base_pair Starts at 83292461 and ends at 83335153 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HPSE   5164
Cards
Entrez_Gene (NCBI)HPSE    heparanase
AliasesHPA; HPA1; HPR1; HPSE1; 
HSE1
GeneCards (Weizmann)HPSE
Ensembl hg19 (Hinxton)ENSG00000173083 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173083 [Gene_View]  ENSG00000173083 [Sequence]  chr4:83292461-83335153 [Contig_View]  HPSE [Vega]
ICGC DataPortalENSG00000173083
TCGA cBioPortalHPSE
AceView (NCBI)HPSE
Genatlas (Paris)HPSE
SOURCE (Princeton)HPSE
Genetics Home Reference (NIH)HPSE
Genomic and cartography
GoldenPath hg38 (UCSC)HPSE  -     chr4:83292461-83335153 -  4q21.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HPSE  -     4q21.23   [Description]    (hg19-Feb_2009)
GoldenPathHPSE - 4q21.23 [CytoView hg19]  HPSE - 4q21.23 [CytoView hg38]
ImmunoBaseENSG00000173083
Genome Data Viewer NCBIHPSE [Mapview hg19]  
OMIM604724   
Gene and transcription
Genbank (Entrez)AF084467 AF144325 AF152376 AF155510 AF165154
RefSeq transcript (Entrez)NM_001098540 NM_001166498 NM_001199830 NM_006665
Consensus coding sequences : CCDS (NCBI)HPSE
Gene ExpressionHPSE [ NCBI-GEO ]   HPSE [ EBI - ARRAY_EXPRESS ]   HPSE [ SEEK ]   HPSE [ MEM ]
Gene Expression Viewer (FireBrowse)HPSE [ Firebrowse - Broad ]
GenevisibleExpression of HPSE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10855
GTEX Portal (Tissue expression)HPSE
Human Protein AtlasENSG00000173083-HPSE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y251   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y251  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y251
Catalytic activity : Enzyme3.2.1.166 [ Enzyme-Expasy ]   3.2.1.1663.2.1.166 [ IntEnz-EBI ]   3.2.1.166 [ BRENDA ]   3.2.1.166 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y251
Domains : Interpro (EBI)Glyco_hydro_79    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_79n (PF03662)   
Domain families : Pfam (NCBI)pfam03662   
Conserved Domain (NCBI)HPSE
PDB (RSDB)5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
PDB Europe5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
PDB (PDBSum)5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
PDB (IMB)5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
Structural Biology KnowledgeBase5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
SCOP (Structural Classification of Proteins)5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
CATH (Classification of proteins structures)5E8M    5E97    5E98    5E9B    5E9C    5L9Y    5L9Z    5LA4    5LA7    6ZDM   
SuperfamilyQ9Y251
AlphaFold pdb e-kbQ9Y251   
Human Protein Atlas [tissue]ENSG00000173083-HPSE [tissue]
HPRD05286
Protein Interaction databases
DIP (DOE-UCLA)Q9Y251
IntAct (EBI)Q9Y251
BioGRIDHPSE
STRING (EMBL)HPSE
ZODIACHPSE
Ontologies - Pathways
QuickGOQ9Y251
Ontology : AmiGObeta-glucuronidase activity  protein binding  extracellular region  extracellular space  nucleus  nucleoplasm  lysosome  lysosomal membrane  proteoglycan metabolic process  cell-matrix adhesion  cell-matrix adhesion  response to organic substance  positive regulation of vascular endothelial growth factor production  positive regulation of blood coagulation  heparan sulfate proteoglycan catabolic process  heparin metabolic process  heparanase activity  extracellular matrix  positive regulation of osteoblast proliferation  specific granule lumen  lysosomal lumen  intracellular membrane-bounded organelle  membrane raft  syndecan binding  regulation of hair follicle development  positive regulation of hair follicle development  positive regulation of protein kinase B signaling  angiogenesis involved in wound healing  establishment of endothelial barrier  vascular wound healing  protein transmembrane transport  
Ontology : EGO-EBIbeta-glucuronidase activity  protein binding  extracellular region  extracellular space  nucleus  nucleoplasm  lysosome  lysosomal membrane  proteoglycan metabolic process  cell-matrix adhesion  cell-matrix adhesion  response to organic substance  positive regulation of vascular endothelial growth factor production  positive regulation of blood coagulation  heparan sulfate proteoglycan catabolic process  heparin metabolic process  heparanase activity  extracellular matrix  positive regulation of osteoblast proliferation  specific granule lumen  lysosomal lumen  intracellular membrane-bounded organelle  membrane raft  syndecan binding  regulation of hair follicle development  positive regulation of hair follicle development  positive regulation of protein kinase B signaling  angiogenesis involved in wound healing  establishment of endothelial barrier  vascular wound healing  protein transmembrane transport  
Pathways : KEGGKEGG_GLYCOSAMINOGLYCAN_DEGRADATION   
NDEx NetworkHPSE
Atlas of Cancer Signalling NetworkHPSE
Wikipedia pathwaysHPSE
Orthology - Evolution
OrthoDB10855
GeneTree (enSembl)ENSG00000173083
Phylogenetic Trees/Animal Genes : TreeFamHPSE
Homologs : HomoloGeneHPSE
Homology/Alignments : Family Browser (UCSC)HPSE
Gene fusions - Rearrangements
Fusion : QuiverHPSE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHPSE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HPSE
dbVarHPSE
ClinVarHPSE
MonarchHPSE
1000_GenomesHPSE 
Exome Variant ServerHPSE
GNOMAD BrowserENSG00000173083
Varsome BrowserHPSE
ACMGHPSE variants
VarityQ9Y251
Genomic Variants (DGV)HPSE [DGVbeta]
DECIPHERHPSE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHPSE 
Mutations
ICGC Data PortalHPSE 
TCGA Data PortalHPSE 
Broad Tumor PortalHPSE
OASIS PortalHPSE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHPSE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHPSE
Mutations and Diseases : HGMDHPSE
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHPSE
DgiDB (Drug Gene Interaction Database)HPSE
DoCM (Curated mutations)HPSE
CIViC (Clinical Interpretations of Variants in Cancer)HPSE
Cancer3DHPSE
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604724   
Orphanet
DisGeNETHPSE
MedgenHPSE
Genetic Testing Registry HPSE
NextProtQ9Y251 [Medical]
GENETestsHPSE
Target ValidationHPSE
Huge Navigator HPSE [HugePedia]
ClinGenHPSE
Clinical trials, drugs, therapy
MyCancerGenomeHPSE
Protein Interactions : CTDHPSE
Pharm GKB GenePA29435
PharosQ9Y251
Clinical trialHPSE
Miscellaneous
canSAR (ICR)HPSE
HarmonizomeHPSE
ARCHS4HPSE
DataMed IndexHPSE
Probes
Litterature
PubMed371 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHPSE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:37:32 CET 2022

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.