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HPSE2 (heparanase 2 (inactive))

Identity

Alias (NCBI)HPA2
HPR2
UFS
UFS1
HGNC (Hugo) HPSE2
HGNC Alias symbHPA2
HPR2
HGNC Previous nameUFS
HGNC Previous nameurofacial syndrome
 heparanase 2
LocusID (NCBI) 60495
Atlas_Id 46219
Location 10q24.2  [Link to chromosome band 10q24]
Location_base_pair Starts at 98457077 and ends at 99235852 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HPSE2 (10q24.2) / CWF19L1 (10q24.31)HPSE2 10q24.2 / CWF19L1 10q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q24;q24) LCOR/HPSE2


External links

 

Nomenclature
HGNC (Hugo)HPSE2   18374
Cards
Entrez_Gene (NCBI)HPSE2    heparanase 2 (inactive)
AliasesHPA2; HPR2; UFS; UFS1
GeneCards (Weizmann)HPSE2
Ensembl hg19 (Hinxton)ENSG00000172987 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172987 [Gene_View]  ENSG00000172987 [Sequence]  chr10:98457077-99235852 [Contig_View]  HPSE2 [Vega]
ICGC DataPortalENSG00000172987
TCGA cBioPortalHPSE2
AceView (NCBI)HPSE2
Genatlas (Paris)HPSE2
SOURCE (Princeton)HPSE2
Genetics Home Reference (NIH)HPSE2
Genomic and cartography
GoldenPath hg38 (UCSC)HPSE2  -     chr10:98457077-99235852 -  10q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HPSE2  -     10q24.2   [Description]    (hg19-Feb_2009)
GoldenPathHPSE2 - 10q24.2 [CytoView hg19]  HPSE2 - 10q24.2 [CytoView hg38]
ImmunoBaseENSG00000172987
Genome Data Viewer NCBIHPSE2 [Mapview hg19]  
OMIM236730   613469   
Gene and transcription
Genbank (Entrez)AF282885 AF282886 AF282887 AJ299719 AJ299720
RefSeq transcript (Entrez)NM_001166244 NM_001166245 NM_001166246 NM_021828
Consensus coding sequences : CCDS (NCBI)HPSE2
Gene ExpressionHPSE2 [ NCBI-GEO ]   HPSE2 [ EBI - ARRAY_EXPRESS ]   HPSE2 [ SEEK ]   HPSE2 [ MEM ]
Gene Expression Viewer (FireBrowse)HPSE2 [ Firebrowse - Broad ]
GenevisibleExpression of HPSE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60495
GTEX Portal (Tissue expression)HPSE2
Human Protein AtlasENSG00000172987-HPSE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWQ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWQ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWQ2
PhosPhoSitePlusQ8WWQ2
Domains : Interpro (EBI)Glyco_hydro_79    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_79n (PF03662)   
Domain families : Pfam (NCBI)pfam03662   
Conserved Domain (NCBI)HPSE2
SuperfamilyQ8WWQ2
AlphaFold pdb e-kbQ8WWQ2   
Human Protein Atlas [tissue]ENSG00000172987-HPSE2 [tissue]
HPRD13669
Protein Interaction databases
DIP (DOE-UCLA)Q8WWQ2
IntAct (EBI)Q8WWQ2
BioGRIDHPSE2
STRING (EMBL)HPSE2
ZODIACHPSE2
Ontologies - Pathways
QuickGOQ8WWQ2
Ontology : AmiGOextracellular region  plasma membrane  glycosaminoglycan catabolic process  biological_process  positive regulation of cell population proliferation  extracellular matrix organization  heparanase activity  heparanase activity  extracellular matrix  extracellular matrix  heparan sulfate proteoglycan binding  
Ontology : EGO-EBIextracellular region  plasma membrane  glycosaminoglycan catabolic process  biological_process  positive regulation of cell population proliferation  extracellular matrix organization  heparanase activity  heparanase activity  extracellular matrix  extracellular matrix  heparan sulfate proteoglycan binding  
Pathways : KEGGGlycosaminoglycan degradation    Proteoglycans in cancer   
NDEx NetworkHPSE2
Atlas of Cancer Signalling NetworkHPSE2
Wikipedia pathwaysHPSE2
Orthology - Evolution
OrthoDB60495
GeneTree (enSembl)ENSG00000172987
Phylogenetic Trees/Animal Genes : TreeFamHPSE2
Homologs : HomoloGeneHPSE2
Homology/Alignments : Family Browser (UCSC)HPSE2
Gene fusions - Rearrangements
Fusion : MitelmanHPSE2/CWF19L1 [10q24.2/10q24.31]  
Fusion : QuiverHPSE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHPSE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HPSE2
dbVarHPSE2
ClinVarHPSE2
MonarchHPSE2
1000_GenomesHPSE2 
Exome Variant ServerHPSE2
GNOMAD BrowserENSG00000172987
Varsome BrowserHPSE2
ACMGHPSE2 variants
VarityQ8WWQ2
Genomic Variants (DGV)HPSE2 [DGVbeta]
DECIPHERHPSE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHPSE2 
Mutations
ICGC Data PortalHPSE2 
TCGA Data PortalHPSE2 
Broad Tumor PortalHPSE2
OASIS PortalHPSE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHPSE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHPSE2
Mutations and Diseases : HGMDHPSE2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHPSE2
DgiDB (Drug Gene Interaction Database)HPSE2
DoCM (Curated mutations)HPSE2
CIViC (Clinical Interpretations of Variants in Cancer)HPSE2
Cancer3DHPSE2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM236730    613469   
Orphanet2465   
DisGeNETHPSE2
MedgenHPSE2
Genetic Testing Registry HPSE2
NextProtQ8WWQ2 [Medical]
GENETestsHPSE2
Target ValidationHPSE2
Huge Navigator HPSE2 [HugePedia]
ClinGenHPSE2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeHPSE2
Protein Interactions : CTDHPSE2
Pharm GKB GenePA38533
PharosQ8WWQ2
Clinical trialHPSE2
Miscellaneous
canSAR (ICR)HPSE2
HarmonizomeHPSE2
DataMed IndexHPSE2
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHPSE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:57 CEST 2021

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