HPX (hemopexin)

2015-11-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
HX
FUSION GENES

Other Information

Locus ID:

NCBI: 3263
MIM: 142290
HGNC: 5171
Ensembl: ENSG00000110169

Variants:

dbSNP: 3263
ClinVar: 3263
TCGA: ENSG00000110169
COSMIC: HPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110169ENST00000265983P02790
ENSG00000110169ENST00000615166Q9BS19

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171853592007Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.47
155580182005CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase.40
206104012010Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.40
198631882009Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease.34
227724442012Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation.34
199660412010MMP20 hemopexin domain mutation in amelogenesis imperfecta.24
211934112011The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions.22
160140372005Protease activity of plasma hemopexin.16
160799872005Altered activity of plasma hemopexin in patients with minimal change disease in relapse.16

Citation

Dessen P

HPX (hemopexin)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/55516/hpx