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HRC (histidine rich calcium binding protein)

Identity

Alias_nameshistidine-rich calcium-binding protein
Alias_symbol (synonym)MGC133236
Other alias-
HGNC (Hugo) HRC
LocusID (NCBI) 3270
Atlas_Id 55599
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49151199 and ends at 49155424 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MIR548N (2q31.2) / HRC (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HRC   5178
Cards
Entrez_Gene (NCBI)HRC  3270  histidine rich calcium binding protein
Aliases
GeneCards (Weizmann)HRC
Ensembl hg19 (Hinxton)ENSG00000130528 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130528 [Gene_View]  chr19:49151199-49155424 [Contig_View]  HRC [Vega]
ICGC DataPortalENSG00000130528
TCGA cBioPortalHRC
AceView (NCBI)HRC
Genatlas (Paris)HRC
WikiGenes3270
SOURCE (Princeton)HRC
Genetics Home Reference (NIH)HRC
Genomic and cartography
GoldenPath hg38 (UCSC)HRC  -     chr19:49151199-49155424 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HRC  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblHRC - 19q13.33 [CytoView hg19]  HRC - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIHRC [Mapview hg19]  HRC [Mapview hg38]
OMIM142705   
Gene and transcription
Genbank (Entrez)AK300706 BC069795 BC069802 BC094691 BC112355
RefSeq transcript (Entrez)NM_002152
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HRC
Cluster EST : UnigeneHs.436885 [ NCBI ]
CGAP (NCI)Hs.436885
Alternative Splicing GalleryENSG00000130528
Gene ExpressionHRC [ NCBI-GEO ]   HRC [ EBI - ARRAY_EXPRESS ]   HRC [ SEEK ]   HRC [ MEM ]
Gene Expression Viewer (FireBrowse)HRC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3270
GTEX Portal (Tissue expression)HRC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23327
Splice isoforms : SwissVarP23327
PhosPhoSitePlusP23327
Domains : Interpro (EBI)Hist_rich_Ca-bd    HRC   
Domain families : Pfam (Sanger)Hist_rich_Ca-bd (PF10529)   
Domain families : Pfam (NCBI)pfam10529   
Conserved Domain (NCBI)HRC
DMDM Disease mutations3270
Blocks (Seattle)HRC
SuperfamilyP23327
Human Protein AtlasENSG00000130528
Peptide AtlasP23327
HPRD00818
IPIIPI00219226   IPI00908566   IPI00914561   IPI00747637   
Protein Interaction databases
DIP (DOE-UCLA)P23327
IntAct (EBI)P23327
FunCoupENSG00000130528
BioGRIDHRC
STRING (EMBL)HRC
ZODIACHRC
Ontologies - Pathways
QuickGOP23327
Ontology : AmiGOregulation of heart rate  calcium ion binding  protein binding  muscle contraction  positive regulation of heart rate  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  Z disc  sarcoplasmic reticulum membrane  sarcoplasmic reticulum lumen  regulation of peptidyl-serine phosphorylation  ion channel binding  positive regulation of heart contraction  ATPase binding  regulation of cytosolic calcium ion concentration  negative regulation of cytosolic calcium ion concentration  regulation of ryanodine-sensitive calcium-release channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  positive regulation of relaxation of cardiac muscle  negative regulation of calcium ion import into sarcoplasmic reticulum  regulation of calcium ion transmembrane transport  
Ontology : EGO-EBIregulation of heart rate  calcium ion binding  protein binding  muscle contraction  positive regulation of heart rate  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  Z disc  sarcoplasmic reticulum membrane  sarcoplasmic reticulum lumen  regulation of peptidyl-serine phosphorylation  ion channel binding  positive regulation of heart contraction  ATPase binding  regulation of cytosolic calcium ion concentration  negative regulation of cytosolic calcium ion concentration  regulation of ryanodine-sensitive calcium-release channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  positive regulation of relaxation of cardiac muscle  negative regulation of calcium ion import into sarcoplasmic reticulum  regulation of calcium ion transmembrane transport  
NDEx NetworkHRC
Atlas of Cancer Signalling NetworkHRC
Wikipedia pathwaysHRC
Orthology - Evolution
OrthoDB3270
GeneTree (enSembl)ENSG00000130528
Phylogenetic Trees/Animal Genes : TreeFamHRC
HOVERGENP23327
HOGENOMP23327
Homologs : HomoloGeneHRC
Homology/Alignments : Family Browser (UCSC)HRC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHRC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HRC
dbVarHRC
ClinVarHRC
1000_GenomesHRC 
Exome Variant ServerHRC
ExAC (Exome Aggregation Consortium)HRC (select the gene name)
Genetic variants : HAPMAP3270
Genomic Variants (DGV)HRC [DGVbeta]
DECIPHERHRC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHRC 
Mutations
ICGC Data PortalHRC 
TCGA Data PortalHRC 
Broad Tumor PortalHRC
OASIS PortalHRC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHRC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHRC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HRC
DgiDB (Drug Gene Interaction Database)HRC
DoCM (Curated mutations)HRC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HRC (select a term)
intoGenHRC
Cancer3DHRC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142705   
Orphanet
MedgenHRC
Genetic Testing Registry HRC
NextProtP23327 [Medical]
TSGene3270
GENETestsHRC
Target ValidationHRC
Huge Navigator HRC [HugePedia]
snp3D : Map Gene to Disease3270
BioCentury BCIQHRC
ClinGenHRC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3270
Chemical/Pharm GKB GenePA29452
Clinical trialHRC
Miscellaneous
canSAR (ICR)HRC (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHRC
EVEXHRC
GoPubMedHRC
iHOPHRC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:37:30 CEST 2017

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