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HRG (histidine rich glycoprotein)

Identity

Alias (NCBI)HPRG
HRGP
THPH11
HGNC (Hugo) HRG
HGNC Alias symbHRGP
HPRG
HGNC Alias namehistidine-proline rich glycoprotein
 thrombophilia due to elevated HRG
HGNC Previous namehistidine-rich glycoprotein
LocusID (NCBI) 3273
Atlas_Id 43976
Location 3q27.3  [Link to chromosome band 3q27]
Location_base_pair Starts at 186666014 and ends at 186678234 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HRG   5181
LRG (Locus Reference Genomic)LRG_601
Cards
Entrez_Gene (NCBI)HRG    histidine rich glycoprotein
AliasesHPRG; HRGP; THPH11
GeneCards (Weizmann)HRG
Ensembl hg19 (Hinxton)ENSG00000113905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113905 [Gene_View]  ENSG00000113905 [Sequence]  chr3:186666014-186678234 [Contig_View]  HRG [Vega]
ICGC DataPortalENSG00000113905
TCGA cBioPortalHRG
AceView (NCBI)HRG
Genatlas (Paris)HRG
SOURCE (Princeton)HRG
Genetics Home Reference (NIH)HRG
Genomic and cartography
GoldenPath hg38 (UCSC)HRG  -     chr3:186666014-186678234 +  3q27.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HRG  -     3q27.3   [Description]    (hg19-Feb_2009)
GoldenPathHRG - 3q27.3 [CytoView hg19]  HRG - 3q27.3 [CytoView hg38]
ImmunoBaseENSG00000113905
Genome Data Viewer NCBIHRG [Mapview hg19]  
OMIM142640   613116   
Gene and transcription
Genbank (Entrez)AI800281 AK313381 BC069574 BC150591 CR749302
RefSeq transcript (Entrez)NM_000412
Consensus coding sequences : CCDS (NCBI)HRG
Gene ExpressionHRG [ NCBI-GEO ]   HRG [ EBI - ARRAY_EXPRESS ]   HRG [ SEEK ]   HRG [ MEM ]
Gene Expression Viewer (FireBrowse)HRG [ Firebrowse - Broad ]
GenevisibleExpression of HRG in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3273
GTEX Portal (Tissue expression)HRG
Human Protein AtlasENSG00000113905-HRG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04196   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04196  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04196
PhosPhoSitePlusP04196
Domains : Interpro (EBI)Cystatin_dom   
Domain families : Pfam (Sanger)Cystatin (PF00031)   
Domain families : Pfam (NCBI)pfam00031   
Domain families : Smart (EMBL)CY (SM00043)  
Conserved Domain (NCBI)HRG
SuperfamilyP04196
AlphaFold pdb e-kbP04196   
Human Protein Atlas [tissue]ENSG00000113905-HRG [tissue]
HPRD00812
Protein Interaction databases
DIP (DOE-UCLA)P04196
IntAct (EBI)P04196
BioGRIDHRG
STRING (EMBL)HRG
ZODIACHRG
Ontologies - Pathways
QuickGOP04196
Ontology : AmiGOangiogenesis  platelet degranulation  positive regulation of immune response to tumor cell  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  signaling receptor binding  protein binding  extracellular region  extracellular region  extracellular region  extracellular region  extracellular region  plasma membrane  chemotaxis  negative regulation of cell adhesion  heparin binding  heparin binding  zinc ion binding  zinc ion binding  negative regulation of cell population proliferation  cell surface  regulation of gene expression  regulation of platelet activation  regulation of platelet activation  negative regulation of lamellipodium assembly  negative regulation of endopeptidase activity  heme transport  negative regulation of angiogenesis  immunoglobulin binding  heme binding  platelet activation  regulation of blood coagulation  negative regulation of cell growth  platelet alpha granule lumen  regulation of actin cytoskeleton organization  negative regulation of cell adhesion mediated by integrin  endolysosome  fibrinolysis  positive regulation of apoptotic process  regulation of protein-containing complex assembly  heparan sulfate proteoglycan binding  negative regulation of blood vessel endothelial cell migration  metal ion binding  regulation of peptidyl-tyrosine phosphorylation  defense response to fungus  cytolysis by host of symbiont cells  positive regulation of focal adhesion assembly  negative regulation of fibrinolysis  antimicrobial humoral immune response mediated by antimicrobial peptide  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of blood vessel remodeling  negative regulation of endothelial cell chemotaxis  
Ontology : EGO-EBIangiogenesis  platelet degranulation  positive regulation of immune response to tumor cell  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  signaling receptor binding  protein binding  extracellular region  extracellular region  extracellular region  extracellular region  extracellular region  plasma membrane  chemotaxis  negative regulation of cell adhesion  heparin binding  heparin binding  zinc ion binding  zinc ion binding  negative regulation of cell population proliferation  cell surface  regulation of gene expression  regulation of platelet activation  regulation of platelet activation  negative regulation of lamellipodium assembly  negative regulation of endopeptidase activity  heme transport  negative regulation of angiogenesis  immunoglobulin binding  heme binding  platelet activation  regulation of blood coagulation  negative regulation of cell growth  platelet alpha granule lumen  regulation of actin cytoskeleton organization  negative regulation of cell adhesion mediated by integrin  endolysosome  fibrinolysis  positive regulation of apoptotic process  regulation of protein-containing complex assembly  heparan sulfate proteoglycan binding  negative regulation of blood vessel endothelial cell migration  metal ion binding  regulation of peptidyl-tyrosine phosphorylation  defense response to fungus  cytolysis by host of symbiont cells  positive regulation of focal adhesion assembly  negative regulation of fibrinolysis  antimicrobial humoral immune response mediated by antimicrobial peptide  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of blood vessel remodeling  negative regulation of endothelial cell chemotaxis  
NDEx NetworkHRG
Atlas of Cancer Signalling NetworkHRG
Wikipedia pathwaysHRG
Orthology - Evolution
OrthoDB3273
GeneTree (enSembl)ENSG00000113905
Phylogenetic Trees/Animal Genes : TreeFamHRG
Homologs : HomoloGeneHRG
Homology/Alignments : Family Browser (UCSC)HRG
Gene fusions - Rearrangements
Fusion : QuiverHRG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHRG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HRG
dbVarHRG
ClinVarHRG
MonarchHRG
1000_GenomesHRG 
Exome Variant ServerHRG
GNOMAD BrowserENSG00000113905
Varsome BrowserHRG
ACMGHRG variants
VarityP04196
Genomic Variants (DGV)HRG [DGVbeta]
DECIPHERHRG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHRG 
Mutations
ICGC Data PortalHRG 
TCGA Data PortalHRG 
Broad Tumor PortalHRG
OASIS PortalHRG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHRG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHRG
Mutations and Diseases : HGMDHRG
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHRG
DgiDB (Drug Gene Interaction Database)HRG
DoCM (Curated mutations)HRG
CIViC (Clinical Interpretations of Variants in Cancer)HRG
Cancer3DHRG
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142640    613116   
Orphanet18859   
DisGeNETHRG
MedgenHRG
Genetic Testing Registry HRG
NextProtP04196 [Medical]
GENETestsHRG
Target ValidationHRG
Huge Navigator HRG [HugePedia]
ClinGenHRG
Clinical trials, drugs, therapy
MyCancerGenomeHRG
Protein Interactions : CTDHRG
Pharm GKB GenePA29455
PharosP04196
Clinical trialHRG
Miscellaneous
canSAR (ICR)HRG
HarmonizomeHRG
DataMed IndexHRG
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHRG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:59 CEST 2021

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