HRG (histidine rich glycoprotein)

2007-02-01  

Identity

HGNC
LOCATION
3q27.3
LOCUSID
ALIAS
HPRG,HRGP,THPH11

Other Information

Locus ID:

NCBI: 3273
MIM: 142640
HGNC: 5181
Ensembl: ENSG00000113905

Variants:

dbSNP: 3273
ClinVar: 3273
TCGA: ENSG00000113905
COSMIC: HRG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113905ENST00000232003P04196

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Dissolution of Fibrin ClotREACTOMER-HSA-75205

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212157062011HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.216
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203030642010Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.33
203030642010Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.33
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
187975152008Histidine-rich glycoprotein protects from systemic Candida infection.19
172291452007Histidine-rich glycoprotein exerts antibacterial activity.18
263548572016Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway.16
151382722004Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation.15
164363872006The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner.15

Citation

Dessen P

HRG (histidine rich glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43976/hrg