HRH1 (histamine receptor H1)

2008-09-01 Affiliation

Identity

HGNC

HRH1

LOCATION

3p25.3

LOCUSID

3269

ALIAS

H1-R,H1R,HH1R,hisH1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3269
MIM: 600167
HGNC: 5182
Ensembl: ENSG00000196639

Variants:

dbSNP: 3269
ClinVar: 3269
TCGA: ENSG00000196639
COSMIC: HRH1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196639	ENST00000397056	P35367
ENSG00000196639	ENST00000413416	C9J2E6
ENSG00000196639	ENST00000431010	P35367
ENSG00000196639	ENST00000438284	P35367

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Histamine receptors	REACTOME	R-HSA-390650
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406954	Weight gain	Disease	MultilinkAnnotation	associated		24279860
PA164776964	desloratadine	Chemical	ClinicalAnnotation	associated	PD	31406237
PA166129521	sedation	Disease	ClinicalAnnotation	associated	PD	31406237
PA445999	Urticaria	Disease	ClinicalAnnotation	associated	PD	31406237

References

Pubmed ID	Year	Title	Citations
21697825	2011	Structure of the human histamine H1 receptor complex with doxepin.	225
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22169095	2012	Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.	64
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
26752109	2016	Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.	46
15542600	2005	Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2.	30
17627982	2007	Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.	28
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
16888049	2006	H1 and H2 receptors mediate postexercise hyperemia in sedentary and endurance exercise-trained men and women.	24
19193342	2008	Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.	22

Citation

Dessen P

HRH1 (histamine receptor H1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50324/hrh1