HRH4 (histamine receptor H4)

2007-02-01  

Identity

HGNC
LOCATION
18q11.2
LOCUSID
ALIAS
AXOR35,BG26,GPCR105,GPRv53,H4,H4R,HH4R
FUSION GENES

Other Information

Locus ID:

NCBI: 59340
MIM: 606792
HGNC: 17383
Ensembl: ENSG00000134489

Variants:

dbSNP: 59340
ClinVar: 59340
TCGA: ENSG00000134489
COSMIC: HRH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134489ENST00000256906Q9H3N8
ENSG00000134489ENST00000426880Q9H3N8

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Histamine receptorsREACTOMER-HSA-390650
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD23422377
PA451257risperidoneChemicalClinicalAnnotationassociatedPD23422377

References

Pubmed IDYearTitleCitations
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
190469502009Localization of histamine H4 receptors in the central nervous system of human and rat.42
192819092009The histamine H4 receptor is functionally expressed on T(H)2 cells.29
162037682005The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.28
176279822007Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
175070842007Histamine downregulates monocyte CCL2 production through the histamine H4 receptor.24
176813652007H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12.21
182396172008Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor.19
249349792014Functional characterization of histamine H4 receptor on human mast cells.19

Citation

Dessen P

HRH4 (histamine receptor H4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45609/hrh4