Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HRH4 (histamine receptor H4)

Identity

Alias_symbol (synonym)H4R
HH4R
AXOR35
GPCR105
GPRv53
Other aliasBG26
H4
HGNC (Hugo) HRH4
LocusID (NCBI) 59340
Atlas_Id 45609
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 24460629 and ends at 24479957 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HRH4 (18q11.2) / BCL6 (3q27.3)HRH4 (18q11.2) / PDGFRB (5q32)HRH4 (18q11.2) / RET (10q11.21)
PDGFRB (5q32) / HRH4 (18q11.2)RET (10q11.21) / HRH4 (18q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HRH4   17383
Cards
Entrez_Gene (NCBI)HRH4  59340  histamine receptor H4
AliasesAXOR35; BG26; GPCR105; GPRv53; 
H4; H4R; HH4R
GeneCards (Weizmann)HRH4
Ensembl hg19 (Hinxton)ENSG00000134489 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134489 [Gene_View]  chr18:24460629-24479957 [Contig_View]  HRH4 [Vega]
ICGC DataPortalENSG00000134489
TCGA cBioPortalHRH4
AceView (NCBI)HRH4
Genatlas (Paris)HRH4
WikiGenes59340
SOURCE (Princeton)HRH4
Genetics Home Reference (NIH)HRH4
Genomic and cartography
GoldenPath hg38 (UCSC)HRH4  -     chr18:24460629-24479957 +  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HRH4  -     18q11.2   [Description]    (hg19-Feb_2009)
EnsemblHRH4 - 18q11.2 [CytoView hg19]  HRH4 - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBIHRH4 [Mapview hg19]  HRH4 [Mapview hg38]
OMIM606792   
Gene and transcription
Genbank (Entrez)AB044934 AB045370 AF307973 AF312230 AF325356
RefSeq transcript (Entrez)NM_001143828 NM_001160166 NM_021624
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HRH4
Cluster EST : UnigeneHs.287388 [ NCBI ]
CGAP (NCI)Hs.287388
Alternative Splicing GalleryENSG00000134489
Gene ExpressionHRH4 [ NCBI-GEO ]   HRH4 [ EBI - ARRAY_EXPRESS ]   HRH4 [ SEEK ]   HRH4 [ MEM ]
Gene Expression Viewer (FireBrowse)HRH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59340
GTEX Portal (Tissue expression)HRH4
Human Protein AtlasENSG00000134489-HRH4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3N8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3N8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3N8
Splice isoforms : SwissVarQ9H3N8
PhosPhoSitePlusQ9H3N8
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Histamine_H4_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)HRH4
DMDM Disease mutations59340
Blocks (Seattle)HRH4
SuperfamilyQ9H3N8
Human Protein Atlas [tissue]ENSG00000134489-HRH4 [tissue]
Peptide AtlasQ9H3N8
HPRD06004
IPIIPI00023596   IPI00909646   IPI00930374   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3N8
IntAct (EBI)Q9H3N8
FunCoupENSG00000134489
BioGRIDHRH4
STRING (EMBL)HRH4
ZODIACHRH4
Ontologies - Pathways
QuickGOQ9H3N8
Ontology : AmiGOhistamine receptor activity  plasma membrane  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  biological_process  integral component of membrane  regulation of MAPK cascade  
Ontology : EGO-EBIhistamine receptor activity  plasma membrane  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  biological_process  integral component of membrane  regulation of MAPK cascade  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkHRH4
Atlas of Cancer Signalling NetworkHRH4
Wikipedia pathwaysHRH4
Orthology - Evolution
OrthoDB59340
GeneTree (enSembl)ENSG00000134489
Phylogenetic Trees/Animal Genes : TreeFamHRH4
HOVERGENQ9H3N8
HOGENOMQ9H3N8
Homologs : HomoloGeneHRH4
Homology/Alignments : Family Browser (UCSC)HRH4
Gene fusions - Rearrangements
Fusion: Tumor Portal HRH4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHRH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HRH4
dbVarHRH4
ClinVarHRH4
1000_GenomesHRH4 
Exome Variant ServerHRH4
ExAC (Exome Aggregation Consortium)ENSG00000134489
GNOMAD BrowserENSG00000134489
Genetic variants : HAPMAP59340
Genomic Variants (DGV)HRH4 [DGVbeta]
DECIPHERHRH4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHRH4 
Mutations
ICGC Data PortalHRH4 
TCGA Data PortalHRH4 
Broad Tumor PortalHRH4
OASIS PortalHRH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHRH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHRH4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HRH4
DgiDB (Drug Gene Interaction Database)HRH4
DoCM (Curated mutations)HRH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HRH4 (select a term)
intoGenHRH4
Cancer3DHRH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606792   
Orphanet
MedgenHRH4
Genetic Testing Registry HRH4
NextProtQ9H3N8 [Medical]
TSGene59340
GENETestsHRH4
Target ValidationHRH4
Huge Navigator HRH4 [HugePedia]
snp3D : Map Gene to Disease59340
BioCentury BCIQHRH4
ClinGenHRH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59340
Chemical/Pharm GKB GenePA134982275
Clinical trialHRH4
Miscellaneous
canSAR (ICR)HRH4 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHRH4
EVEXHRH4
GoPubMedHRH4
iHOPHRH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:53:28 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.