HRNR (hornerin)

2013-02-01  

Identity

HGNC
HRNR
LOCATION
1q21.3
LOCUSID
388697
ALIAS
FLG3,S100A16,S100a18

Other Information

Locus ID:

NCBI: 388697
MIM: 616293
HGNC: 20846
Ensembl: ENSG00000197915

Variants:

dbSNP: 388697
ClinVar: 388697
TCGA: ENSG00000197915
COSMIC: HRNR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197915ENST00000368801Q86YZ3

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
276781212016Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.11
277425732017Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases.4
196019982009Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.3
155074462005Identification of human hornerin and its expression in regenerating and psoriatic skin.0
190205532009Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin.0
212822072011Hornerin is a component of the epidermal cornified cell envelopes.0
227273332012Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer.0
235577452013Association of the chromosome 11q13.5 variant with atopic dermatitis in Austrian patients.0
237512022014Ultraviolet B irradiation induces the expression of hornerin in xenotransplanted human skin.0
289167562017Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity.0

Citation

Dessen P

HRNR (hornerin)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53156/hrnr