HS6ST2 (heparan sulfate 6-O-sulfotransferase 2)

2011-08-01  

Identity

HGNC
LOCATION
Xq26.2
LOCUSID
ALIAS
MRXSPM
FUSION GENES

Other Information

Locus ID:

NCBI: 90161
MIM: 300545
HGNC: 19133
Ensembl: ENSG00000171004

Variants:

dbSNP: 90161
ClinVar: 90161
TCGA: ENSG00000171004
COSMIC: HS6ST2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171004ENST00000370833Q96MM7
ENSG00000171004ENST00000370836Q96MM7
ENSG00000171004ENST00000406696Q96MM7
ENSG00000171004ENST00000521489Q96MM7
ENSG00000171004ENST00000640529A0A1W2PQ14

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGko00534
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGhsa00534
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG biosynthesisREACTOMER-HSA-2022928

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380580802023Downregulation of HS6ST2 Inhibits Cervical Cancer Cell Migration and Invasion in Vivo and in Vitro.0
380580802023Downregulation of HS6ST2 Inhibits Cervical Cancer Cell Migration and Invasion in Vivo and in Vitro.0
352600442022Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis.3
352600442022Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis.3
304710912019A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins.11
304710912019A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins.11
298995282018Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis.16
298995282018Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis.16
291042772017Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.17
291042772017Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.17
245634832014Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.34
245634832014Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.34
214435202011Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling.17
214435202011Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling.17
124923992003Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.24

Citation

Dessen P

HS6ST2 (heparan sulfate 6-O-sulfotransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52350/hs6st2