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HSCB (HscB mitochondrial iron-sulfur cluster cochaperone)

Identity

Alias (NCBI)DNAJC20
HSC20
JAC1
HGNC (Hugo) HSCB
HGNC Alias symbHSC20
DNAJC20
Jac1
HGNC Alias nameDnaJ (Hsp40) homolog, subfamily C, member 20
HGNC Previous nameHscB iron-sulfur cluster co-chaperone homolog (E. coli)
LocusID (NCBI) 150274
Atlas_Id 46982
Location 22q12.1  [Link to chromosome band 22q12]
Location_base_pair Starts at 28742039 and ends at 28757508 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF18 (19p13.2) / HSCB (22q12.1)HSCB (22q12.1) / CFAP206 (6q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HSCB   28913
Cards
Entrez_Gene (NCBI)HSCB    HscB mitochondrial iron-sulfur cluster cochaperone
AliasesDNAJC20; HSC20; JAC1
GeneCards (Weizmann)HSCB
Ensembl hg19 (Hinxton)ENSG00000100209 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100209 [Gene_View]  ENSG00000100209 [Sequence]  chr22:28742039-28757508 [Contig_View]  HSCB [Vega]
ICGC DataPortalENSG00000100209
TCGA cBioPortalHSCB
AceView (NCBI)HSCB
Genatlas (Paris)HSCB
SOURCE (Princeton)HSCB
Genetics Home Reference (NIH)HSCB
Genomic and cartography
GoldenPath hg38 (UCSC)HSCB  -     chr22:28742039-28757508 +  22q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSCB  -     22q12.1   [Description]    (hg19-Feb_2009)
GoldenPathHSCB - 22q12.1 [CytoView hg19]  HSCB - 22q12.1 [CytoView hg38]
ImmunoBaseENSG00000100209
Genome Data Viewer NCBIHSCB [Mapview hg19]  
OMIM608142   
Gene and transcription
Genbank (Entrez)AA804625 AY191719 BC000004 BC065569 BG696148
RefSeq transcript (Entrez)NM_001318314 NM_001318315 NM_001318316 NM_001363856 NM_172002
Consensus coding sequences : CCDS (NCBI)HSCB
Gene ExpressionHSCB [ NCBI-GEO ]   HSCB [ EBI - ARRAY_EXPRESS ]   HSCB [ SEEK ]   HSCB [ MEM ]
Gene Expression Viewer (FireBrowse)HSCB [ Firebrowse - Broad ]
GenevisibleExpression of HSCB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150274
GTEX Portal (Tissue expression)HSCB
Human Protein AtlasENSG00000100209-HSCB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWL3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWL3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWL3
PhosPhoSitePlusQ8IWL3
Domains : Interpro (EBI)DnaJ_domain    HscB    HscB_4_cys    HscB_C_sf    HscB_oligo_C    J_dom_sf   
Domain families : Pfam (Sanger)HscB_4_cys (PF18256)    HSCB_C (PF07743)   
Domain families : Pfam (NCBI)pfam18256    pfam07743   
Conserved Domain (NCBI)HSCB
PDB (RSDB)3BVO   
PDB Europe3BVO   
PDB (PDBSum)3BVO   
PDB (IMB)3BVO   
Structural Biology KnowledgeBase3BVO   
SCOP (Structural Classification of Proteins)3BVO   
CATH (Classification of proteins structures)3BVO   
SuperfamilyQ8IWL3
AlphaFold pdb e-kbQ8IWL3   
Human Protein Atlas [tissue]ENSG00000100209-HSCB [tissue]
HPRD16289
Protein Interaction databases
DIP (DOE-UCLA)Q8IWL3
IntAct (EBI)Q8IWL3
BioGRIDHSCB
STRING (EMBL)HSCB
ZODIACHSCB
Ontologies - Pathways
QuickGOQ8IWL3
Ontology : AmiGOATPase activator activity  molecular_function  protein binding  nucleoplasm  cytoplasm  mitochondrion  mitochondrion  mitochondrion  cytosol  iron-sulfur cluster assembly  identical protein binding  [2Fe-2S] cluster assembly  metal ion binding  regulation of catalytic activity  chaperone binding  protein complex oligomerization  protein maturation by iron-sulfur cluster transfer  
Ontology : EGO-EBIATPase activator activity  molecular_function  protein binding  nucleoplasm  cytoplasm  mitochondrion  mitochondrion  mitochondrion  cytosol  iron-sulfur cluster assembly  identical protein binding  [2Fe-2S] cluster assembly  metal ion binding  regulation of catalytic activity  chaperone binding  protein complex oligomerization  protein maturation by iron-sulfur cluster transfer  
NDEx NetworkHSCB
Atlas of Cancer Signalling NetworkHSCB
Wikipedia pathwaysHSCB
Orthology - Evolution
OrthoDB150274
GeneTree (enSembl)ENSG00000100209
Phylogenetic Trees/Animal Genes : TreeFamHSCB
Homologs : HomoloGeneHSCB
Homology/Alignments : Family Browser (UCSC)HSCB
Gene fusions - Rearrangements
Fusion : QuiverHSCB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSCB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSCB
dbVarHSCB
ClinVarHSCB
MonarchHSCB
1000_GenomesHSCB 
Exome Variant ServerHSCB
GNOMAD BrowserENSG00000100209
Varsome BrowserHSCB
ACMGHSCB variants
VarityQ8IWL3
Genomic Variants (DGV)HSCB [DGVbeta]
DECIPHERHSCB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSCB 
Mutations
ICGC Data PortalHSCB 
TCGA Data PortalHSCB 
Broad Tumor PortalHSCB
OASIS PortalHSCB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSCB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHSCB
Mutations and Diseases : HGMDHSCB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHSCB
DgiDB (Drug Gene Interaction Database)HSCB
DoCM (Curated mutations)HSCB
CIViC (Clinical Interpretations of Variants in Cancer)HSCB
Cancer3DHSCB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608142   
Orphanet
DisGeNETHSCB
MedgenHSCB
Genetic Testing Registry HSCB
NextProtQ8IWL3 [Medical]
GENETestsHSCB
Target ValidationHSCB
Huge Navigator HSCB [HugePedia]
ClinGenHSCB
Clinical trials, drugs, therapy
MyCancerGenomeHSCB
Protein Interactions : CTDHSCB
Pharm GKB GenePA162391621
PharosQ8IWL3
Clinical trialHSCB
Miscellaneous
canSAR (ICR)HSCB
HarmonizomeHSCB
DataMed IndexHSCB
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHSCB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:02 CEST 2021

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