Identity
HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
17-beta-HSD,20-alpha-HSD,E2DH,EDH17B2,EDHB17,HSD17,SDR28C1
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3292
MIM: 109684
HGNC: 5210
Ensembl: ENSG00000108786
Variants:
dbSNP: 3292
ClinVar: 3292
TCGA: ENSG00000108786
COSMIC: HSD17B1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000108786 | ENST00000225929 | A0A0A0MQS7 |
| ENSG00000108786 | ENST00000585807 | P14061 |
| ENSG00000108786 | ENST00000590299 | B4DU11 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36634828 | 2023 | New insights into the substrate inhibition of human 17β-hydroxysteroid dehydrogenase type 1. | 0 |
| 36634828 | 2023 | New insights into the substrate inhibition of human 17β-hydroxysteroid dehydrogenase type 1. | 0 |
| 35563206 | 2022 | Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice. | 2 |
| 35563206 | 2022 | Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice. | 2 |
| 34764940 | 2021 | Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20α/20βHSD Activity. | 5 |
| 34764940 | 2021 | Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20α/20βHSD Activity. | 5 |
| 31989268 | 2020 | G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto. | 0 |
| 32161197 | 2020 | Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. | 37 |
| 32236582 | 2020 | Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer. | 3 |
| 31989268 | 2020 | G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto. | 0 |
| 32161197 | 2020 | Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. | 37 |
| 32236582 | 2020 | Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer. | 3 |
| 30768851 | 2019 | Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP(+) reveal the mechanism of substrate inhibition. | 5 |
| 30768851 | 2019 | Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP(+) reveal the mechanism of substrate inhibition. | 5 |
| 29941172 | 2018 | Estrogen-related receptor γ regulates expression of 17β-hydroxysteroid dehydrogenase type 1 in fetal growth restriction. | 8 |
Citation
Dessen P
HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40867/hsd17b1
