Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HSD17B11 (hydroxysteroid (17-beta) dehydrogenase 11)

Identity

Alias_namesDHRS8
dehydrogenase/reductase (SDR family) member 8
hydroxysteroid (17-beta) dehydrogenase 11
Alias_symbol (synonym)RetSDR2
17-BETA-HSD11
17-BETA-HSDXI
PAN1B
SDR16C2
Other alias17BHSD11
RETSDR2
HGNC (Hugo) HSD17B11
LocusID (NCBI) 51170
Atlas_Id 51079
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 88257677 and ends at 88312455 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLASP1 (2q14.2) / HSD17B11 (4q22.1)HSD17B11 (4q22.1) / HSD17B11 (4q22.1)HSD17B11 (4q22.1) / HSD17B13 (4q22.1)
PROM1 (4p15.32) / HSD17B11 (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSD17B11   22960
Cards
Entrez_Gene (NCBI)HSD17B11  51170  hydroxysteroid (17-beta) dehydrogenase 11
Aliases17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11; DHRS8; 
PAN1B; RETSDR2; SDR16C2
GeneCards (Weizmann)HSD17B11
Ensembl hg19 (Hinxton)ENSG00000198189 [Gene_View]  chr4:88257677-88312455 [Contig_View]  HSD17B11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198189 [Gene_View]  chr4:88257677-88312455 [Contig_View]  HSD17B11 [Vega]
ICGC DataPortalENSG00000198189
TCGA cBioPortalHSD17B11
AceView (NCBI)HSD17B11
Genatlas (Paris)HSD17B11
WikiGenes51170
SOURCE (Princeton)HSD17B11
Genetics Home Reference (NIH)HSD17B11
Genomic and cartography
GoldenPath hg19 (UCSC)HSD17B11  -     chr4:88257677-88312455 -  4q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HSD17B11  -     4q22.1   [Description]    (hg38-Dec_2013)
EnsemblHSD17B11 - 4q22.1 [CytoView hg19]  HSD17B11 - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBIHSD17B11 [Mapview hg19]  HSD17B11 [Mapview hg38]
OMIM612831   
Gene and transcription
Genbank (Entrez)AF126780 AF273056 AK075348 AY358553 BC008650
RefSeq transcript (Entrez)NM_016245
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)HSD17B11
Cluster EST : UnigeneHs.594923 [ NCBI ]
CGAP (NCI)Hs.594923
Alternative Splicing GalleryENSG00000198189
Gene ExpressionHSD17B11 [ NCBI-GEO ]   HSD17B11 [ EBI - ARRAY_EXPRESS ]   HSD17B11 [ SEEK ]   HSD17B11 [ MEM ]
Gene Expression Viewer (FireBrowse)HSD17B11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51170
GTEX Portal (Tissue expression)HSD17B11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NBQ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NBQ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NBQ5
Splice isoforms : SwissVarQ8NBQ5
Catalytic activity : Enzyme1.1.1.62 [ Enzyme-Expasy ]   1.1.1.621.1.1.62 [ IntEnz-EBI ]   1.1.1.62 [ BRENDA ]   1.1.1.62 [ KEGG ]   
PhosPhoSitePlusQ8NBQ5
Domains : Interpro (EBI)DH_sc/Rdtase_SDR    Glc/ribitol_DH    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
Conserved Domain (NCBI)HSD17B11
DMDM Disease mutations51170
Blocks (Seattle)HSD17B11
PDB (SRS)1YB1   
PDB (PDBSum)1YB1   
PDB (IMB)1YB1   
PDB (RSDB)1YB1   
Structural Biology KnowledgeBase1YB1   
SCOP (Structural Classification of Proteins)1YB1   
CATH (Classification of proteins structures)1YB1   
SuperfamilyQ8NBQ5
Human Protein AtlasENSG00000198189
Peptide AtlasQ8NBQ5
HPRD10881
IPIIPI00329598   IPI00966408   
Protein Interaction databases
DIP (DOE-UCLA)Q8NBQ5
IntAct (EBI)Q8NBQ5
FunCoupENSG00000198189
BioGRIDHSD17B11
STRING (EMBL)HSD17B11
ZODIACHSD17B11
Ontologies - Pathways
QuickGOQ8NBQ5
Ontology : AmiGOestradiol 17-beta-dehydrogenase activity  extracellular region  cytoplasm  lipid particle  cytosol  estrogen biosynthetic process  androgen catabolic process  steroid dehydrogenase activity  intracellular membrane-bounded organelle  oxidation-reduction process  
Ontology : EGO-EBIestradiol 17-beta-dehydrogenase activity  extracellular region  cytoplasm  lipid particle  cytosol  estrogen biosynthetic process  androgen catabolic process  steroid dehydrogenase activity  intracellular membrane-bounded organelle  oxidation-reduction process  
NDEx NetworkHSD17B11
Atlas of Cancer Signalling NetworkHSD17B11
Wikipedia pathwaysHSD17B11
Orthology - Evolution
OrthoDB51170
GeneTree (enSembl)ENSG00000198189
Phylogenetic Trees/Animal Genes : TreeFamHSD17B11
HOVERGENQ8NBQ5
HOGENOMQ8NBQ5
Homologs : HomoloGeneHSD17B11
Homology/Alignments : Family Browser (UCSC)HSD17B11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSD17B11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSD17B11
dbVarHSD17B11
ClinVarHSD17B11
1000_GenomesHSD17B11 
Exome Variant ServerHSD17B11
ExAC (Exome Aggregation Consortium)HSD17B11 (select the gene name)
Genetic variants : HAPMAP51170
Genomic Variants (DGV)HSD17B11 [DGVbeta]
DECIPHER (Syndromes)4:88257677-88312455  ENSG00000198189
CONAN: Copy Number AnalysisHSD17B11 
Mutations
ICGC Data PortalHSD17B11 
TCGA Data PortalHSD17B11 
Broad Tumor PortalHSD17B11
OASIS PortalHSD17B11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSD17B11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSD17B11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSD17B11
DgiDB (Drug Gene Interaction Database)HSD17B11
DoCM (Curated mutations)HSD17B11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSD17B11 (select a term)
intoGenHSD17B11
Cancer3DHSD17B11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612831   
Orphanet
MedgenHSD17B11
Genetic Testing Registry HSD17B11
NextProtQ8NBQ5 [Medical]
TSGene51170
GENETestsHSD17B11
Huge Navigator HSD17B11 [HugePedia]
snp3D : Map Gene to Disease51170
BioCentury BCIQHSD17B11
ClinGenHSD17B11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51170
Chemical/Pharm GKB GenePA162391655
Clinical trialHSD17B11
Miscellaneous
canSAR (ICR)HSD17B11 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSD17B11
EVEXHSD17B11
GoPubMedHSD17B11
iHOPHSD17B11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:04:23 CEST 2017

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