HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11)

2009-09-01  

Identity

HGNC
HSD17B11
LOCATION
4q22.1
LOCUSID
51170
ALIAS
17-BETA-HSD11,17-BETA-HSDXI,17BHSD11,DHRS8,PAN1B,RETSDR2,SDR16C2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51170
MIM: 612831
HGNC: 22960
Ensembl: ENSG00000198189

Variants:

dbSNP: 51170
ClinVar: 51170
TCGA: ENSG00000198189
COSMIC: HSD17B11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198189ENST00000358290Q8NBQ5
ENSG00000198189ENST00000507286D6RCD0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Estrogen biosynthesisREACTOMER-HSA-193144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188044472008Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11.15
12697717200317 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.9
19469652200917beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer.4
215498062011Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells.1
264727322016Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties.1

Citation

Dessen P

HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51079/hsd17b11