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HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)

Identity

Alias_nameshydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
hydroxysteroid (17-beta) dehydrogenase 6
Alias_symbol (synonym)HSE
RODH
SDR9C6
Other alias
HGNC (Hugo) HSD17B6
LocusID (NCBI) 8630
Atlas_Id 54826
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56763218 and ends at 56787790 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSD17B6   23316
Cards
Entrez_Gene (NCBI)HSD17B6  8630  hydroxysteroid 17-beta dehydrogenase 6
AliasesHSE; RODH; SDR9C6
GeneCards (Weizmann)HSD17B6
Ensembl hg19 (Hinxton)ENSG00000025423 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000025423 [Gene_View]  chr12:56763218-56787790 [Contig_View]  HSD17B6 [Vega]
ICGC DataPortalENSG00000025423
TCGA cBioPortalHSD17B6
AceView (NCBI)HSD17B6
Genatlas (Paris)HSD17B6
WikiGenes8630
SOURCE (Princeton)HSD17B6
Genetics Home Reference (NIH)HSD17B6
Genomic and cartography
GoldenPath hg38 (UCSC)HSD17B6  -     chr12:56763218-56787790 +  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSD17B6  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblHSD17B6 - 12q13.3 [CytoView hg19]  HSD17B6 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBIHSD17B6 [Mapview hg19]  HSD17B6 [Mapview hg38]
OMIM606623   
Gene and transcription
Genbank (Entrez)AA934892 AF016509 AF223225 AI760144 AK313423
RefSeq transcript (Entrez)NM_003725
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSD17B6
Cluster EST : UnigeneHs.524513 [ NCBI ]
CGAP (NCI)Hs.524513
Alternative Splicing GalleryENSG00000025423
Gene ExpressionHSD17B6 [ NCBI-GEO ]   HSD17B6 [ EBI - ARRAY_EXPRESS ]   HSD17B6 [ SEEK ]   HSD17B6 [ MEM ]
Gene Expression Viewer (FireBrowse)HSD17B6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8630
GTEX Portal (Tissue expression)HSD17B6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14756   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14756  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14756
Splice isoforms : SwissVarO14756
Catalytic activity : Enzyme1.1.1.105 [ Enzyme-Expasy ]   1.1.1.1051.1.1.105 [ IntEnz-EBI ]   1.1.1.105 [ BRENDA ]   1.1.1.105 [ KEGG ]   
PhosPhoSitePlusO14756
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)NAD(P)-bd_dom    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
Conserved Domain (NCBI)HSD17B6
DMDM Disease mutations8630
Blocks (Seattle)HSD17B6
SuperfamilyO14756
Human Protein AtlasENSG00000025423
Peptide AtlasO14756
HPRD09431
IPIIPI00099595   IPI01025674   IPI01026381   
Protein Interaction databases
DIP (DOE-UCLA)O14756
IntAct (EBI)O14756
FunCoupENSG00000025423
BioGRIDHSD17B6
STRING (EMBL)HSD17B6
ZODIACHSD17B6
Ontologies - Pathways
QuickGOO14756
Ontology : AmiGOcatalytic activity  estradiol 17-beta-dehydrogenase activity  retinol dehydrogenase activity  intracellular  endoplasmic reticulum  androgen biosynthetic process  androgen catabolic process  electron carrier activity  oxidoreductase activity  early endosome membrane  testosterone dehydrogenase (NAD+) activity  oxidation-reduction process  
Ontology : EGO-EBIcatalytic activity  estradiol 17-beta-dehydrogenase activity  retinol dehydrogenase activity  intracellular  endoplasmic reticulum  androgen biosynthetic process  androgen catabolic process  electron carrier activity  oxidoreductase activity  early endosome membrane  testosterone dehydrogenase (NAD+) activity  oxidation-reduction process  
Pathways : KEGGSteroid hormone biosynthesis    Retinol metabolism   
NDEx NetworkHSD17B6
Atlas of Cancer Signalling NetworkHSD17B6
Wikipedia pathwaysHSD17B6
Orthology - Evolution
OrthoDB8630
GeneTree (enSembl)ENSG00000025423
Phylogenetic Trees/Animal Genes : TreeFamHSD17B6
HOVERGENO14756
HOGENOMO14756
Homologs : HomoloGeneHSD17B6
Homology/Alignments : Family Browser (UCSC)HSD17B6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSD17B6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSD17B6
dbVarHSD17B6
ClinVarHSD17B6
1000_GenomesHSD17B6 
Exome Variant ServerHSD17B6
ExAC (Exome Aggregation Consortium)HSD17B6 (select the gene name)
Genetic variants : HAPMAP8630
Genomic Variants (DGV)HSD17B6 [DGVbeta]
DECIPHERHSD17B6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSD17B6 
Mutations
ICGC Data PortalHSD17B6 
TCGA Data PortalHSD17B6 
Broad Tumor PortalHSD17B6
OASIS PortalHSD17B6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSD17B6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSD17B6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSD17B6
DgiDB (Drug Gene Interaction Database)HSD17B6
DoCM (Curated mutations)HSD17B6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSD17B6 (select a term)
intoGenHSD17B6
Cancer3DHSD17B6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606623   
Orphanet
MedgenHSD17B6
Genetic Testing Registry HSD17B6
NextProtO14756 [Medical]
TSGene8630
GENETestsHSD17B6
Target ValidationHSD17B6
Huge Navigator HSD17B6 [HugePedia]
snp3D : Map Gene to Disease8630
BioCentury BCIQHSD17B6
ClinGenHSD17B6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8630
Chemical/Pharm GKB GenePA142671671
Clinical trialHSD17B6
Miscellaneous
canSAR (ICR)HSD17B6 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSD17B6
EVEXHSD17B6
GoPubMedHSD17B6
iHOPHSD17B6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:37:36 CEST 2017

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