Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HSF1 (heat shock transcription factor 1)

Identity

Alias_symbol (synonym)HSTF1
Other alias
HGNC (Hugo) HSF1
LocusID (NCBI) 3297
Atlas_Id 40870
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 145515270 and ends at 145538385 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EIF5A (17p13.1) / HSF1 (8q24.3)HSF1 (8q24.3) / ADAMTS12 (5p13.3)HSF1 (8q24.3) / BAIAP2L1 (7q21.3)
HSF1 (8q24.3) / BOP1 (8q24.3)HSF1 (8q24.3) / HSF1 (8q24.3)UBE2M (19q13.43) / HSF1 (8q24.3)
HSF1 8q24.3 / ADAMTS12 5p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSF1   5224
Cards
Entrez_Gene (NCBI)HSF1  3297  heat shock transcription factor 1
AliasesHSTF1
GeneCards (Weizmann)HSF1
Ensembl hg19 (Hinxton)ENSG00000185122 [Gene_View]  chr8:145515270-145538385 [Contig_View]  HSF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185122 [Gene_View]  chr8:145515270-145538385 [Contig_View]  HSF1 [Vega]
ICGC DataPortalENSG00000185122
TCGA cBioPortalHSF1
AceView (NCBI)HSF1
Genatlas (Paris)HSF1
WikiGenes3297
SOURCE (Princeton)HSF1
Genetics Home Reference (NIH)HSF1
Genomic and cartography
GoldenPath hg19 (UCSC)HSF1  -     chr8:145515270-145538385 +  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HSF1  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblHSF1 - 8q24.3 [CytoView hg19]  HSF1 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIHSF1 [Mapview hg19]  HSF1 [Mapview hg38]
OMIM140580   
Gene and transcription
Genbank (Entrez)AF299094 AK054762 AK125467 AK126580 AK222497
RefSeq transcript (Entrez)NM_005526
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929341
Consensus coding sequences : CCDS (NCBI)HSF1
Cluster EST : UnigeneHs.530227 [ NCBI ]
CGAP (NCI)Hs.530227
Alternative Splicing GalleryENSG00000185122
Gene ExpressionHSF1 [ NCBI-GEO ]   HSF1 [ EBI - ARRAY_EXPRESS ]   HSF1 [ SEEK ]   HSF1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3297
GTEX Portal (Tissue expression)HSF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00613   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00613  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00613
Splice isoforms : SwissVarQ00613
PhosPhoSitePlusQ00613
Domaine pattern : Prosite (Expaxy)HSF_DOMAIN (PS00434)   
Domains : Interpro (EBI)HSF1    HSF_DNA-bd    HSF_fam    Vert_HSTF_C    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)HSF_DNA-bind (PF00447)    Vert_HS_TF (PF06546)   
Domain families : Pfam (NCBI)pfam00447    pfam06546   
Domain families : Smart (EMBL)HSF (SM00415)  
Conserved Domain (NCBI)HSF1
DMDM Disease mutations3297
Blocks (Seattle)HSF1
PDB (SRS)2LDU    5D5U    5D5V   
PDB (PDBSum)2LDU    5D5U    5D5V   
PDB (IMB)2LDU    5D5U    5D5V   
PDB (RSDB)2LDU    5D5U    5D5V   
Structural Biology KnowledgeBase2LDU    5D5U    5D5V   
SCOP (Structural Classification of Proteins)2LDU    5D5U    5D5V   
CATH (Classification of proteins structures)2LDU    5D5U    5D5V   
SuperfamilyQ00613
Human Protein AtlasENSG00000185122
Peptide AtlasQ00613
HPRD00778
IPIIPI00024071   IPI00218507   IPI00902551   IPI00940195   IPI00978861   IPI00871163   
Protein Interaction databases
DIP (DOE-UCLA)Q00613
IntAct (EBI)Q00613
FunCoupENSG00000185122
BioGRIDHSF1
STRING (EMBL)HSF1
ZODIACHSF1
Ontologies - Pathways
QuickGOQ00613
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding  embryonic placenta development  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  defense response  female meiotic division  spermatogenesis  negative regulation of cell proliferation  mRNA transcription  response to lipopolysaccharide  negative regulation of tumor necrosis factor production  cellular response to heat  positive regulation of multicellular organism growth  protein complex  pronucleus  positive regulation of transcription from RNA polymerase II promoter  embryonic process involved in female pregnancy  regulation of cellular response to heat  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding  embryonic placenta development  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  defense response  female meiotic division  spermatogenesis  negative regulation of cell proliferation  mRNA transcription  response to lipopolysaccharide  negative regulation of tumor necrosis factor production  cellular response to heat  positive regulation of multicellular organism growth  protein complex  pronucleus  positive regulation of transcription from RNA polymerase II promoter  embryonic process involved in female pregnancy  regulation of cellular response to heat  
Pathways : KEGGLegionellosis   
NDEx NetworkHSF1
Atlas of Cancer Signalling NetworkHSF1
Wikipedia pathwaysHSF1
Orthology - Evolution
OrthoDB3297
GeneTree (enSembl)ENSG00000185122
Phylogenetic Trees/Animal Genes : TreeFamHSF1
HOVERGENQ00613
HOGENOMQ00613
Homologs : HomoloGeneHSF1
Homology/Alignments : Family Browser (UCSC)HSF1
Gene fusions - Rearrangements
Fusion : MitelmanHSF1/ADAMTS12 [8q24.3/5p13.3]  
Fusion: TCGAHSF1 8q24.3 ADAMTS12 5p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSF1
dbVarHSF1
ClinVarHSF1
1000_GenomesHSF1 
Exome Variant ServerHSF1
ExAC (Exome Aggregation Consortium)HSF1 (select the gene name)
Genetic variants : HAPMAP3297
Genomic Variants (DGV)HSF1 [DGVbeta]
DECIPHER (Syndromes)8:145515270-145538385  ENSG00000185122
CONAN: Copy Number AnalysisHSF1 
Mutations
ICGC Data PortalHSF1 
TCGA Data PortalHSF1 
Broad Tumor PortalHSF1
OASIS PortalHSF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSF1
DgiDB (Drug Gene Interaction Database)HSF1
DoCM (Curated mutations)HSF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSF1 (select a term)
intoGenHSF1
Cancer3DHSF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140580   
Orphanet
MedgenHSF1
Genetic Testing Registry HSF1
NextProtQ00613 [Medical]
TSGene3297
GENETestsHSF1
Huge Navigator HSF1 [HugePedia]
snp3D : Map Gene to Disease3297
BioCentury BCIQHSF1
ClinGenHSF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3297
Chemical/Pharm GKB GenePA29493
Clinical trialHSF1
Miscellaneous
canSAR (ICR)HSF1 (select the gene name)
Probes
Litterature
PubMed239 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSF1
EVEXHSF1
GoPubMedHSF1
iHOPHSF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:09:51 CET 2017

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