HSF1 (heat shock transcription factor 1)

2003-08-01  

Identity

HGNC
HSF1
LOCATION
8q24.3
LOCUSID
3297
ALIAS
HSTF1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3297
MIM: 140580
HGNC: 5224
Ensembl: ENSG00000185122

Variants:

dbSNP: 3297
ClinVar: 3297
TCGA: ENSG00000185122
COSMIC: HSF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185122ENST00000400780E9PMQ6
ENSG00000185122ENST00000528838Q00613
ENSG00000185122ENST00000528988A0A087WXG6
ENSG00000185122ENST00000530661A0A087WWQ3
ENSG00000185122ENST00000533240E9PI02
ENSG00000185122ENST00000534314A0A087X1F9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
178896462007Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.359
192290362009Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.256
228630082012HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.224
220428602011High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.122
157604752005Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.110
126655922003Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.107
250838682014The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.106
238690222013Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.96
193350682009Inhibiting the transcription factor HSF1 as an anticancer strategy.94
160515982005Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.88

Citation

Dessen P

HSF1 (heat shock transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40870/hsf1