HSF2 (heat shock transcription factor 2)

2007-02-01  

Identity

HGNC
HSF2
LOCATION
6q22.31
LOCUSID
3298
ALIAS
HSF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3298
MIM: 140581
HGNC: 5225
Ensembl: ENSG00000025156

Variants:

dbSNP: 3298
ClinVar: 3298
TCGA: ENSG00000025156
COSMIC: HSF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025156ENST00000368455Q03933
ENSG00000025156ENST00000452194Q03933
ENSG00000025156ENST00000465214V9GZ44

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
156620142005Mechanism of hsp70i gene bookmarking.74
172131962007Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191294772009Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.48
239598602013Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells.46
128654372003Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70.34
128130382003Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress.29
179155612007HSF2 binds to the Hsp90, Hsp27, and c-Fos promoters constitutively and modulates their expression.21
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
230648882013A dominant-negative mutation of HSF2 associated with idiopathic azoospermia.17

Citation

Dessen P

HSF2 (heat shock transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43866/hsf2