Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HSF2 (heat shock transcription factor 2)

Identity

Other aliasHSF 2
HSTF 2
HGNC (Hugo) HSF2
LocusID (NCBI) 3298
Atlas_Id 43866
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 122399551 and ends at 122433119 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HSF2 (6q22.31) / SERINC1 (6q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSF2   5225
Cards
Entrez_Gene (NCBI)HSF2  3298  heat shock transcription factor 2
AliasesHSF; HSTF
GeneCards (Weizmann)HSF2
Ensembl hg19 (Hinxton)ENSG00000025156 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000025156 [Gene_View]  ENSG00000025156 [Sequence]  chr6:122399551-122433119 [Contig_View]  HSF2 [Vega]
ICGC DataPortalENSG00000025156
TCGA cBioPortalHSF2
AceView (NCBI)HSF2
Genatlas (Paris)HSF2
WikiGenes3298
SOURCE (Princeton)HSF2
Genetics Home Reference (NIH)HSF2
Genomic and cartography
GoldenPath hg38 (UCSC)HSF2  -     chr6:122399551-122433119 +  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSF2  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblHSF2 - 6q22.31 [CytoView hg19]  HSF2 - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBIHSF2 [Mapview hg19]  HSF2 [Mapview hg38]
OMIM140581   
Gene and transcription
Genbank (Entrez)AK225593 AK225594 AK294624 AK316377 BC005329
RefSeq transcript (Entrez)NM_001135564 NM_001243094 NM_004506
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSF2
Cluster EST : UnigeneHs.158195 [ NCBI ]
CGAP (NCI)Hs.158195
Alternative Splicing GalleryENSG00000025156
Gene ExpressionHSF2 [ NCBI-GEO ]   HSF2 [ EBI - ARRAY_EXPRESS ]   HSF2 [ SEEK ]   HSF2 [ MEM ]
Gene Expression Viewer (FireBrowse)HSF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3298
GTEX Portal (Tissue expression)HSF2
Human Protein AtlasENSG00000025156-HSF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03933   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03933  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03933
Splice isoforms : SwissVarQ03933
PhosPhoSitePlusQ03933
Domaine pattern : Prosite (Expaxy)HSF_DOMAIN (PS00434)   
Domains : Interpro (EBI)HSF2    HSF_DNA-bd    HSF_fam    Vert_HSTF_C    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)HSF_DNA-bind (PF00447)    Vert_HS_TF (PF06546)   
Domain families : Pfam (NCBI)pfam00447    pfam06546   
Domain families : Smart (EMBL)HSF (SM00415)  
Conserved Domain (NCBI)HSF2
DMDM Disease mutations3298
Blocks (Seattle)HSF2
PDB (SRS)5D8K    5D8L    5HDK   
PDB (PDBSum)5D8K    5D8L    5HDK   
PDB (IMB)5D8K    5D8L    5HDK   
PDB (RSDB)5D8K    5D8L    5HDK   
Structural Biology KnowledgeBase5D8K    5D8L    5HDK   
SCOP (Structural Classification of Proteins)5D8K    5D8L    5HDK   
CATH (Classification of proteins structures)5D8K    5D8L    5HDK   
SuperfamilyQ03933
Human Protein Atlas [tissue]ENSG00000025156-HSF2 [tissue]
Peptide AtlasQ03933
HPRD00779
IPIIPI00012878   IPI00913872   
Protein Interaction databases
DIP (DOE-UCLA)Q03933
IntAct (EBI)Q03933
FunCoupENSG00000025156
BioGRIDHSF2
STRING (EMBL)HSF2
ZODIACHSF2
Ontologies - Pathways
QuickGOQ03933
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription by RNA polymerase II  spermatogenesis  cellular response to heat  protein homodimerization activity  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription from RNA polymerase II promoter in response to heat stress  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription by RNA polymerase II  spermatogenesis  cellular response to heat  protein homodimerization activity  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription from RNA polymerase II promoter in response to heat stress  
NDEx NetworkHSF2
Atlas of Cancer Signalling NetworkHSF2
Wikipedia pathwaysHSF2
Orthology - Evolution
OrthoDB3298
GeneTree (enSembl)ENSG00000025156
Phylogenetic Trees/Animal Genes : TreeFamHSF2
HOVERGENQ03933
HOGENOMQ03933
Homologs : HomoloGeneHSF2
Homology/Alignments : Family Browser (UCSC)HSF2
Gene fusions - Rearrangements
Fusion : QuiverHSF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSF2
dbVarHSF2
ClinVarHSF2
1000_GenomesHSF2 
Exome Variant ServerHSF2
ExAC (Exome Aggregation Consortium)ENSG00000025156
GNOMAD BrowserENSG00000025156
Varsome BrowserHSF2
Genetic variants : HAPMAP3298
Genomic Variants (DGV)HSF2 [DGVbeta]
DECIPHERHSF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSF2 
Mutations
ICGC Data PortalHSF2 
TCGA Data PortalHSF2 
Broad Tumor PortalHSF2
OASIS PortalHSF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSF2
DgiDB (Drug Gene Interaction Database)HSF2
DoCM (Curated mutations)HSF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSF2 (select a term)
intoGenHSF2
Cancer3DHSF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140581   
Orphanet
DisGeNETHSF2
MedgenHSF2
Genetic Testing Registry HSF2
NextProtQ03933 [Medical]
TSGene3298
GENETestsHSF2
Target ValidationHSF2
Huge Navigator HSF2 [HugePedia]
snp3D : Map Gene to Disease3298
BioCentury BCIQHSF2
ClinGenHSF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3298
Chemical/Pharm GKB GenePA29494
Clinical trialHSF2
Miscellaneous
canSAR (ICR)HSF2 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSF2
EVEXHSF2
GoPubMedHSF2
iHOPHSF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:10 CET 2018

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