HSH2D (hematopoietic SH2 domain containing)

2014-11-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
ALX,HSH2
FUSION GENES

Other Information

Locus ID:

NCBI: 84941
MIM: 608349
HGNC: 24920
Ensembl: ENSG00000196684

Variants:

dbSNP: 84941
ClinVar: 84941
TCGA: ENSG00000196684
COSMIC: HSH2D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196684ENST00000586872K7ES08
ENSG00000196684ENST00000591154K7ER77
ENSG00000196684ENST00000593031K7EP18
ENSG00000196684ENST00000613195A0A087X0V9
ENSG00000196684ENST00000613986Q96JZ2
ENSG00000196684ENST00000616070A0A087WT88
ENSG00000196684ENST00000616645Q96JZ2

Expression (GTEx)

0
50
100
150

References

Pubmed IDYearTitleCitations
200806362010Resolvin D1 binds human phagocytes with evidence for proresolving receptors.257
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
241667362014Lipoxin A₄ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism.23
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
129601722003Cloning and characterization of ALX, an adaptor downstream of CD28.10
278604532017Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.9
117000212001HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells.5
152842402004The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP.5
161698522005The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.5

Citation

Dessen P

HSH2D (hematopoietic SH2 domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64450/hsh2d