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HSP90AA1 (heat shock protein 90 alpha family class A member 1)

Identity

Alias_namesHSPC1
HSPCA
heat shock 90kD protein 1, alpha
heat shock 90kDa protein 1, alpha
heat shock protein 90kDa alpha (cytosolic), class A member 1
Alias_symbol (synonym)Hsp89
Hsp90
FLJ31884
HSP90N
Other aliasEL52
HEL-S-65p
HSP86
HSP89A
HSP90A
HSPCAL1
HSPCAL4
HSPN
Hsp103
LAP-2
LAP2
HGNC (Hugo) HSP90AA1
LocusID (NCBI) 3320
Atlas_Id 40886
Location 14q32.31  [Link to chromosome band 14q32]
Location_base_pair Starts at 102080738 and ends at 102139749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AP3D1 (19p13.3) / HSP90AA1 (14q32.31)B4GALT5 (20q13.13) / HSP90AA1 (14q32.31)BCL6 (3q27.3) / HSP90AA1 (14q32.31)
C1orf112 (1q24.2) / HSP90AA1 (14q32.31)CDKAL1 (6p22.3) / HSP90AA1 (14q32.31)EIF3B (7p22.3) / HSP90AA1 (14q32.31)
HIST1H2BK (6p22.1) / HSP90AA1 (14q32.31)HLA-C (6p21.33) / HSP90AA1 (14q32.31)HSP90AA1 (14q32.31) / ARHGAP32 (11q24.3)
HSP90AA1 (14q32.31) / BCL6 (3q27.3)HSP90AA1 (14q32.31) / C14orf37 (14q23.1)HSP90AA1 (14q32.31) / CALD1 (7q33)
HSP90AA1 (14q32.31) / CCDC91 (12p11.22)HSP90AA1 (14q32.31) / DHX38 (16q22.2)HSP90AA1 (14q32.31) / DYNC1H1 (14q32.31)
HSP90AA1 (14q32.31) / GNAI2 (3p21.31)HSP90AA1 (14q32.31) / HSP90AA1 (14q32.31)HSP90AA1 (14q32.31) / LINC00914 ()
HSP90AA1 (14q32.31) / MIR6723 (1p36.33)HSP90AA1 (14q32.31) / MS4A6A (11q12.2)HSP90AA1 (14q32.31) / NFRKB (11q24.3)
HSP90AA1 (14q32.31) / PAIP1 (5p12)HSP90AA1 (14q32.31) / PCDHB5 (5q31.3)HSP90AA1 (14q32.31) / RNF31 (14q12)
HSP90AA1 (14q32.31) / VPS13B (8q22.2)LARS (5q32) / HSP90AA1 (14q32.31)LOC442459 () / HSP90AA1 (14q32.31)
MALAT1 (11q13.1) / HSP90AA1 (14q32.31)PAIP1 (5p12) / HSP90AA1 (14q32.31)PHC2 (1p35.1) / HSP90AA1 (14q32.31)
PTPN12 (7q11.23) / HSP90AA1 (14q32.31)RFC2 (7q11.23) / HSP90AA1 (14q32.31)RPL38 (17q25.1) / HSP90AA1 (14q32.31)
SHFM1 (7q21.3) / HSP90AA1 (14q32.31)CDKAL1 6p22.3 / HSP90AA1 14q32.31HSP90AA1 14q32.31 RAGE
PHC2 1p35.1 / HSP90AA1 14q32.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;14)(q27;q32) HSP90AA1/BCL6


External links

Nomenclature
HGNC (Hugo)HSP90AA1   5253
Cards
Entrez_Gene (NCBI)HSP90AA1  3320  heat shock protein 90 alpha family class A member 1
AliasesEL52; HEL-S-65p; HSP86; HSP89A; 
HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp103; Hsp89; Hsp90; LAP-2; LAP2
GeneCards (Weizmann)HSP90AA1
Ensembl hg19 (Hinxton)ENSG00000080824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080824 [Gene_View]  chr14:102080738-102139749 [Contig_View]  HSP90AA1 [Vega]
ICGC DataPortalENSG00000080824
TCGA cBioPortalHSP90AA1
AceView (NCBI)HSP90AA1
Genatlas (Paris)HSP90AA1
WikiGenes3320
SOURCE (Princeton)HSP90AA1
Genetics Home Reference (NIH)HSP90AA1
Genomic and cartography
GoldenPath hg38 (UCSC)HSP90AA1  -     chr14:102080738-102139749 -  14q32.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSP90AA1  -     14q32.31   [Description]    (hg19-Feb_2009)
EnsemblHSP90AA1 - 14q32.31 [CytoView hg19]  HSP90AA1 - 14q32.31 [CytoView hg38]
Mapping of homologs : NCBIHSP90AA1 [Mapview hg19]  HSP90AA1 [Mapview hg38]
OMIM140571   
Gene and transcription
Genbank (Entrez)AF028832 AI250920 AJ890082 AJ890083 AK056446
RefSeq transcript (Entrez)NM_001017963 NM_005348
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSP90AA1
Cluster EST : UnigeneHs.525600 [ NCBI ]
CGAP (NCI)Hs.525600
Alternative Splicing GalleryENSG00000080824
Gene ExpressionHSP90AA1 [ NCBI-GEO ]   HSP90AA1 [ EBI - ARRAY_EXPRESS ]   HSP90AA1 [ SEEK ]   HSP90AA1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSP90AA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3320
GTEX Portal (Tissue expression)HSP90AA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07900   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07900  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07900
Splice isoforms : SwissVarP07900
PhosPhoSitePlusP07900
Domaine pattern : Prosite (Expaxy)HSP90 (PS00298)   
Domains : Interpro (EBI)HATPase_C    Heat_shock_protein_90_CS    Hsp90_fam    Hsp90_N    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)HATPase_c (PF02518)    HSP90 (PF00183)   
Domain families : Pfam (NCBI)pfam02518    pfam00183   
Domain families : Smart (EMBL)HATPase_c (SM00387)  
Conserved Domain (NCBI)HSP90AA1
DMDM Disease mutations3320
Blocks (Seattle)HSP90AA1
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP07900
Human Protein AtlasENSG00000080824
Peptide AtlasP07900
HPRD00777
IPIIPI00784295   IPI00382470   IPI00910046   IPI00604607   IPI01024910   IPI01024776   IPI01025664   
Protein Interaction databases
DIP (DOE-UCLA)P07900
IntAct (EBI)P07900
FunCoupENSG00000080824
BioGRIDHSP90AA1
STRING (EMBL)HSP90AA1
ZODIACHSP90AA1
Ontologies - Pathways
QuickGOP07900
Ontology : AmiGOG2/M transition of mitotic cell cycle  nucleotide binding  RNA binding  protein tyrosine kinase activity  protein binding  ATP binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  mitochondrial transport  receptor-mediated endocytosis  response to unfolded protein  telomere maintenance via telomerase  signal transduction  response to heat  response to cold  membrane  ATPase activity  peptidyl-tyrosine phosphorylation  MHC class II protein complex binding  nitric-oxide synthase regulator activity  TPR domain binding  TPR domain binding  regulation of protein ubiquitination  ruffle membrane  secretory granule lumen  Fc-gamma receptor signaling pathway involved in phagocytosis  ERBB2 signaling pathway  protein refolding  melanosome  identical protein binding  protein homodimerization activity  histone deacetylase binding  lysosomal lumen  myelin sheath  regulation of protein complex assembly  neutrophil degranulation  protein unfolding  protein import into mitochondrial outer membrane  positive regulation of nitric oxide biosynthetic process  response to antibiotic  vascular endothelial growth factor receptor signaling pathway  protein stabilization  protein stabilization  regulation of nitric-oxide synthase activity  GTPase binding  unfolded protein binding  chaperone-mediated protein complex assembly  positive regulation of telomerase activity  chaperone-mediated autophagy  extracellular exosome  DNA polymerase binding  endocytic vesicle lumen  ciliary basal body docking  disordered domain specific binding  regulation of cellular response to heat  ficolin-1-rich granule lumen  telomerase holoenzyme complex assembly  protein tyrosine kinase binding  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  nucleotide binding  RNA binding  protein tyrosine kinase activity  protein binding  ATP binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  mitochondrial transport  receptor-mediated endocytosis  response to unfolded protein  telomere maintenance via telomerase  signal transduction  response to heat  response to cold  membrane  ATPase activity  peptidyl-tyrosine phosphorylation  MHC class II protein complex binding  nitric-oxide synthase regulator activity  TPR domain binding  TPR domain binding  regulation of protein ubiquitination  ruffle membrane  secretory granule lumen  Fc-gamma receptor signaling pathway involved in phagocytosis  ERBB2 signaling pathway  protein refolding  melanosome  identical protein binding  protein homodimerization activity  histone deacetylase binding  lysosomal lumen  myelin sheath  regulation of protein complex assembly  neutrophil degranulation  protein unfolding  protein import into mitochondrial outer membrane  positive regulation of nitric oxide biosynthetic process  response to antibiotic  vascular endothelial growth factor receptor signaling pathway  protein stabilization  protein stabilization  regulation of nitric-oxide synthase activity  GTPase binding  unfolded protein binding  chaperone-mediated protein complex assembly  positive regulation of telomerase activity  chaperone-mediated autophagy  extracellular exosome  DNA polymerase binding  endocytic vesicle lumen  ciliary basal body docking  disordered domain specific binding  regulation of cellular response to heat  ficolin-1-rich granule lumen  telomerase holoenzyme complex assembly  protein tyrosine kinase binding  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkHSP90AA1
Atlas of Cancer Signalling NetworkHSP90AA1
Wikipedia pathwaysHSP90AA1
Orthology - Evolution
OrthoDB3320
GeneTree (enSembl)ENSG00000080824
Phylogenetic Trees/Animal Genes : TreeFamHSP90AA1
HOVERGENP07900
HOGENOMP07900
Homologs : HomoloGeneHSP90AA1
Homology/Alignments : Family Browser (UCSC)HSP90AA1
Gene fusions - Rearrangements
Fusion : MitelmanCDKAL1/HSP90AA1 [6p22.3/14q32.31]  [t(6;14)(p22;q32)]  
Fusion : MitelmanHSP90AA1/BCL6 [14q32.31/3q27.3]  [t(3;14)(q27;q32)]  
Fusion : MitelmanPHC2/HSP90AA1 [1p35.1/14q32.31]  [t(1;14)(p35;q32)]  
Fusion : MitelmanPTPN12/HSP90AA1 [7q11.23/14q32.31]  [t(7;14)(q11;q32)]  
Fusion: TCGACDKAL1 6p22.3 HSP90AA1 14q32.31 BRCA
Fusion: TCGAHSP90AA1 14q32.31 RAGE LUSC
Fusion: TCGAPHC2 1p35.1 HSP90AA1 14q32.31 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSP90AA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSP90AA1
dbVarHSP90AA1
ClinVarHSP90AA1
1000_GenomesHSP90AA1 
Exome Variant ServerHSP90AA1
ExAC (Exome Aggregation Consortium)HSP90AA1 (select the gene name)
Genetic variants : HAPMAP3320
Genomic Variants (DGV)HSP90AA1 [DGVbeta]
DECIPHERHSP90AA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSP90AA1 
Mutations
ICGC Data PortalHSP90AA1 
TCGA Data PortalHSP90AA1 
Broad Tumor PortalHSP90AA1
OASIS PortalHSP90AA1 [ Somatic mutations - Copy number]
Cancer Gene: CensusHSP90AA1 
Somatic Mutations in Cancer : COSMICHSP90AA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSP90AA1
intOGen PortalHSP90AA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSP90AA1
DgiDB (Drug Gene Interaction Database)HSP90AA1
DoCM (Curated mutations)HSP90AA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSP90AA1 (select a term)
intoGenHSP90AA1
Cancer3DHSP90AA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140571   
Orphanet
MedgenHSP90AA1
Genetic Testing Registry HSP90AA1
NextProtP07900 [Medical]
TSGene3320
GENETestsHSP90AA1
Target ValidationHSP90AA1
Huge Navigator HSP90AA1 [HugePedia]
snp3D : Map Gene to Disease3320
BioCentury BCIQHSP90AA1
ClinGenHSP90AA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3320
Chemical/Pharm GKB GenePA29519
Clinical trialHSP90AA1
Miscellaneous
canSAR (ICR)HSP90AA1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSP90AA1
EVEXHSP90AA1
GoPubMedHSP90AA1
iHOPHSP90AA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:29 CEST 2017

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