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HSP90AB1 (heat shock protein 90 alpha family class B member 1)

Identity

Alias_namesHSPC2
HSPCB
heat shock 90kD protein 1, beta
heat shock 90kDa protein 1, beta
heat shock protein 90kDa alpha (cytosolic), class B member 1
Other aliasD6S182
HSP84
HSP90B
HGNC (Hugo) HSP90AB1
LocusID (NCBI) 3326
Atlas_Id 40887
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 44246958 and ends at 44253888 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL6 (3q27.3) / HSP90AB1 (6p21.1)HSP90AB1 (6p21.1) / ANKLE2 (12q24.33)HSP90AB1 (6p21.1) / BCL6 (3q27.3)
HSP90AB1 (6p21.1) / DNAJC21 (5p13.2)HSP90AB1 (6p21.1) / HSP90AB1 (6p21.1)HSP90AB1 (6p21.1) / NAPEPLD (7q22.1)
HSP90AB1 (6p21.1) / PCGF2 (17q12)HSP90AB1 (6p21.1) / PTCHD4 (6p12.3)HSP90AB1 (6p21.1) / SLC29A1 (6p21.1)
HSP90AB1 (6p21.1) / TAF3 (10p14)HSP90AB1 (6p21.1) / TVAS5 ()LOC100507412 (-) / HSP90AB1 (6p21.1)
RASA2 (3q23) / HSP90AB1 (6p21.1)SH3GLB1 (1p22.3) / HSP90AB1 (6p21.1)SLC29A1 (6p21.1) / HSP90AB1 (6p21.1)
SYNGAP1 (6p21.32) / HSP90AB1 (6p21.1)TMEM164 (Xq23) / HSP90AB1 (6p21.1)XIAP (Xq25) / HSP90AB1 (6p21.1)
HSP90AB1 6p21.1 / SLC29A1 6p21.1HSP90AB1 6p21.1 / TAF3 10p14

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p21) SLC29A1/HSP90AB1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 11 ]
  t(6;6)(p12;p21) HSP90AB1/PTCHD4
HSP90AB1/SLC29A1 (6p21)
SLC29A1/HSP90AB1 (6p21)
SLC29A1/HSP90AB1 (6p21)
SLC29A1/HSP90AB1 (6p21)
SLC29A1/HSP90AB1 (6p21)
SLC29A1/HSP90AB1 (6p21)
SLC29A1/HSP90AB1 (6p21)
SYNGAP1/HSP90AB1 (6p21)
t(6;10)(p21;p14) HSP90AB1/TAF3
t(6;17)(p21;q12) HSP90AB1/PCGF2

External links

Nomenclature
HGNC (Hugo)HSP90AB1   5258
Cards
Entrez_Gene (NCBI)HSP90AB1  3326  heat shock protein 90 alpha family class B member 1
AliasesD6S182; HSP84; HSP90B; HSPC2; 
HSPCB
GeneCards (Weizmann)HSP90AB1
Ensembl hg19 (Hinxton)ENSG00000096384 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000096384 [Gene_View]  ENSG00000096384 [Sequence]  chr6:44246958-44253888 [Contig_View]  HSP90AB1 [Vega]
ICGC DataPortalENSG00000096384
TCGA cBioPortalHSP90AB1
AceView (NCBI)HSP90AB1
Genatlas (Paris)HSP90AB1
WikiGenes3326
SOURCE (Princeton)HSP90AB1
Genetics Home Reference (NIH)HSP90AB1
Genomic and cartography
GoldenPath hg38 (UCSC)HSP90AB1  -     chr6:44246958-44253888 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSP90AB1  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblHSP90AB1 - 6p21.1 [CytoView hg19]  HSP90AB1 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIHSP90AB1 [Mapview hg19]  HSP90AB1 [Mapview hg38]
OMIM140572   
Gene and transcription
Genbank (Entrez)AF275719 AK025370 AK130494 AK290734 AK294643
RefSeq transcript (Entrez)NM_001271969 NM_001271970 NM_001271971 NM_001271972 NM_007355
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSP90AB1
Cluster EST : UnigeneHs.509736 [ NCBI ]
CGAP (NCI)Hs.509736
Alternative Splicing GalleryENSG00000096384
Gene ExpressionHSP90AB1 [ NCBI-GEO ]   HSP90AB1 [ EBI - ARRAY_EXPRESS ]   HSP90AB1 [ SEEK ]   HSP90AB1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSP90AB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3326
GTEX Portal (Tissue expression)HSP90AB1
Human Protein AtlasENSG00000096384-HSP90AB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08238   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08238
Splice isoforms : SwissVarP08238
PhosPhoSitePlusP08238
Domaine pattern : Prosite (Expaxy)HSP90 (PS00298)   
Domains : Interpro (EBI)HATPase_C    HATPase_C_sf    Heat_shock_protein_90_CS    HSP90_C    Hsp90_fam    Hsp90_N    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)HATPase_c (PF02518)    HSP90 (PF00183)   
Domain families : Pfam (NCBI)pfam02518    pfam00183   
Domain families : Smart (EMBL)HATPase_c (SM00387)  
Conserved Domain (NCBI)HSP90AB1
DMDM Disease mutations3326
Blocks (Seattle)HSP90AB1
PDB (SRS)1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
PDB (PDBSum)1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
PDB (IMB)1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
PDB (RSDB)1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
Structural Biology KnowledgeBase1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
SCOP (Structural Classification of Proteins)1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
CATH (Classification of proteins structures)1QZ2    1UYM    2L6J    3FWV    3NMQ    3PRY    3UQ3    5FWK    5FWL    5FWM    5FWP    5UC4    5UCH    5UCI    5UCJ   
SuperfamilyP08238
Human Protein Atlas [tissue]ENSG00000096384-HSP90AB1 [tissue]
Peptide AtlasP08238
HPRD06763
IPIIPI00414676   IPI00746291   IPI00515119   IPI00640129   IPI00411633   IPI00514027   
Protein Interaction databases
DIP (DOE-UCLA)P08238
IntAct (EBI)P08238
FunCoupENSG00000096384
BioGRIDHSP90AB1
STRING (EMBL)HSP90AB1
ZODIACHSP90AB1
Ontologies - Pathways
QuickGOP08238
Ontology : AmiGOplacenta development  UTP binding  CTP binding  RNA binding  double-stranded RNA binding  protein binding  ATP binding  ATP binding  GTP binding  extracellular region  extracellular region  nucleus  nucleoplasm  cytoplasm  mitochondrion  lysosomal membrane  cytosol  cytosol  protein folding  xenobiotic metabolic process  response to unfolded protein  telomere maintenance via telomerase  COP9 signalosome  response to salt stress  cell surface  membrane  inclusion body  basolateral plasma membrane  apical plasma membrane  sulfonylurea receptor binding  virion attachment to host cell  protein kinase regulator activity  kinase binding  protein kinase binding  central nervous system neuron axonogenesis  MHC class II protein complex binding  establishment of cell polarity  nitric-oxide synthase regulator activity  positive regulation of transforming growth factor beta receptor signaling pathway  TPR domain binding  heat shock protein binding  regulation of protein ubiquitination  brush border membrane  ubiquitin protein ligase binding  positive regulation of protein binding  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of phosphoprotein phosphatase activity  dATP binding  protein-containing complex  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  positive regulation of protein import into nucleus, translocation  aryl hydrocarbon receptor complex  secretory granule lumen  cellular response to drug  Fc-gamma receptor signaling pathway involved in phagocytosis  response to cocaine  peptide binding  melanosome  ATPase activity, coupled  identical protein binding  protein homodimerization activity  histone deacetylase binding  ATP-dependent protein binding  neuronal cell body  neutrophil degranulation  negative regulation of neuron apoptotic process  dendritic growth cone  axonal growth cone  ion channel binding  cadherin binding  positive regulation of nitric oxide biosynthetic process  positive regulation of cell differentiation  positive regulation of cell size  protein dimerization activity  tau protein binding  perinuclear region of cytoplasm  axon extension  protein stabilization  unfolded protein binding  chaperone-mediated protein complex assembly  negative regulation of protein metabolic process  positive regulation of protein kinase B signaling  positive regulation of telomerase activity  regulation of interferon-gamma-mediated signaling pathway  regulation of type I interferon-mediated signaling pathway  extracellular exosome  DNA polymerase binding  negative regulation of cell cycle arrest  cellular response to interleukin-4  cellular response to organic cyclic compound  positive regulation of protein serine/threonine kinase activity  supramolecular fiber organization  disordered domain specific binding  regulation of cellular response to heat  negative regulation of transforming growth factor beta activation  negative regulation of proteasomal protein catabolic process  positive regulation of tau-protein kinase activity  negative regulation of complement-dependent cytotoxicity  regulation of cellular protein localization  positive regulation of cyclin-dependent protein kinase activity  ficolin-1-rich granule lumen  telomerase holoenzyme complex assembly  histone methyltransferase binding  sperm head plasma membrane  ooplasm  positive regulation of protein localization to cell surface  
Ontology : EGO-EBIplacenta development  UTP binding  CTP binding  RNA binding  double-stranded RNA binding  protein binding  ATP binding  ATP binding  GTP binding  extracellular region  extracellular region  nucleus  nucleoplasm  cytoplasm  mitochondrion  lysosomal membrane  cytosol  cytosol  protein folding  xenobiotic metabolic process  response to unfolded protein  telomere maintenance via telomerase  COP9 signalosome  response to salt stress  cell surface  membrane  inclusion body  basolateral plasma membrane  apical plasma membrane  sulfonylurea receptor binding  virion attachment to host cell  protein kinase regulator activity  kinase binding  protein kinase binding  central nervous system neuron axonogenesis  MHC class II protein complex binding  establishment of cell polarity  nitric-oxide synthase regulator activity  positive regulation of transforming growth factor beta receptor signaling pathway  TPR domain binding  heat shock protein binding  regulation of protein ubiquitination  brush border membrane  ubiquitin protein ligase binding  positive regulation of protein binding  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of phosphoprotein phosphatase activity  dATP binding  protein-containing complex  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  positive regulation of protein import into nucleus, translocation  aryl hydrocarbon receptor complex  secretory granule lumen  cellular response to drug  Fc-gamma receptor signaling pathway involved in phagocytosis  response to cocaine  peptide binding  melanosome  ATPase activity, coupled  identical protein binding  protein homodimerization activity  histone deacetylase binding  ATP-dependent protein binding  neuronal cell body  neutrophil degranulation  negative regulation of neuron apoptotic process  dendritic growth cone  axonal growth cone  ion channel binding  cadherin binding  positive regulation of nitric oxide biosynthetic process  positive regulation of cell differentiation  positive regulation of cell size  protein dimerization activity  tau protein binding  perinuclear region of cytoplasm  axon extension  protein stabilization  unfolded protein binding  chaperone-mediated protein complex assembly  negative regulation of protein metabolic process  positive regulation of protein kinase B signaling  positive regulation of telomerase activity  regulation of interferon-gamma-mediated signaling pathway  regulation of type I interferon-mediated signaling pathway  extracellular exosome  DNA polymerase binding  negative regulation of cell cycle arrest  cellular response to interleukin-4  cellular response to organic cyclic compound  positive regulation of protein serine/threonine kinase activity  supramolecular fiber organization  disordered domain specific binding  regulation of cellular response to heat  negative regulation of transforming growth factor beta activation  negative regulation of proteasomal protein catabolic process  positive regulation of tau-protein kinase activity  negative regulation of complement-dependent cytotoxicity  regulation of cellular protein localization  positive regulation of cyclin-dependent protein kinase activity  ficolin-1-rich granule lumen  telomerase holoenzyme complex assembly  histone methyltransferase binding  sperm head plasma membrane  ooplasm  positive regulation of protein localization to cell surface  
Pathways : KEGG   
NDEx NetworkHSP90AB1
Atlas of Cancer Signalling NetworkHSP90AB1
Wikipedia pathwaysHSP90AB1
Orthology - Evolution
OrthoDB3326
GeneTree (enSembl)ENSG00000096384
Phylogenetic Trees/Animal Genes : TreeFamHSP90AB1
HOVERGENP08238
HOGENOMP08238
Homologs : HomoloGeneHSP90AB1
Homology/Alignments : Family Browser (UCSC)HSP90AB1
Gene fusions - Rearrangements
Fusion : MitelmanHSP90AB1/PCGF2 [6p21.1/17q12]  
Fusion : MitelmanHSP90AB1/PTCHD4 [6p21.1/6p12.3]  [t(6;6)(p12;p21)]  
Fusion : MitelmanHSP90AB1/SLC29A1 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanHSP90AB1/TAF3 [6p21.1/10p14]  [t(6;10)(p21;p14)]  
Fusion : MitelmanSLC29A1/HSP90AB1 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanSYNGAP1/HSP90AB1 [6p21.32/6p21.1]  [t(6;6)(p21;p21)]  
Fusion PortalHSP90AB1 6p21.1 SLC29A1 6p21.1 BRCA
Fusion PortalHSP90AB1 6p21.1 TAF3 10p14 BRCA
Fusion Cancer (Beijing)HSP90AB1 [6p21.1]  -  TVAS5 [FUSC001644]
Fusion : QuiverHSP90AB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSP90AB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSP90AB1
dbVarHSP90AB1
ClinVarHSP90AB1
1000_GenomesHSP90AB1 
Exome Variant ServerHSP90AB1
ExAC (Exome Aggregation Consortium)ENSG00000096384
GNOMAD BrowserENSG00000096384
Varsome BrowserHSP90AB1
Genetic variants : HAPMAP3326
Genomic Variants (DGV)HSP90AB1 [DGVbeta]
DECIPHERHSP90AB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSP90AB1 
Mutations
ICGC Data PortalHSP90AB1 
TCGA Data PortalHSP90AB1 
Broad Tumor PortalHSP90AB1
OASIS PortalHSP90AB1 [ Somatic mutations - Copy number]
Cancer Gene: CensusHSP90AB1 
Somatic Mutations in Cancer : COSMICHSP90AB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSP90AB1
intOGen PortalHSP90AB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSP90AB1
DgiDB (Drug Gene Interaction Database)HSP90AB1
DoCM (Curated mutations)HSP90AB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSP90AB1 (select a term)
intoGenHSP90AB1
Cancer3DHSP90AB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140572   
Orphanet
DisGeNETHSP90AB1
MedgenHSP90AB1
Genetic Testing Registry HSP90AB1
NextProtP08238 [Medical]
TSGene3326
GENETestsHSP90AB1
Target ValidationHSP90AB1
Huge Navigator HSP90AB1 [HugePedia]
snp3D : Map Gene to Disease3326
BioCentury BCIQHSP90AB1
ClinGenHSP90AB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3326
Chemical/Pharm GKB GenePA29524
Clinical trialHSP90AB1
Miscellaneous
canSAR (ICR)HSP90AB1 (select the gene name)
Probes
Litterature
PubMed296 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSP90AB1
EVEXHSP90AB1
GoPubMedHSP90AB1
iHOPHSP90AB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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