HSP90B1 (heat shock protein 90 beta family member 1)

2003-02-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
ECGP,GP96,GRP94,HEL-S-125m,HEL35,TRA1
FUSION GENES

Other Information

Locus ID:

NCBI: 7184
MIM: 191175
HGNC: 12028
Ensembl: ENSG00000166598

Variants:

dbSNP: 7184
ClinVar: 7184
TCGA: ENSG00000166598
COSMIC: HSP90B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166598ENST00000299767P14625
ENSG00000166598ENST00000299767V9HWP2
ENSG00000166598ENST00000540297F8VPC7
ENSG00000166598ENST00000549334F8W026
ENSG00000166598ENST00000550595H0YIV0
ENSG00000166598ENST00000614327Q96GW1
ENSG00000166598ENST00000640977A0A1W2PRR1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Prostate cancerKEGGko05215
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
ATF6 (ATF6-alpha) activates chaperonesREACTOMER-HSA-381033
ATF6 (ATF6-alpha) activates chaperone genesREACTOMER-HSA-381183
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class A ReceptorsREACTOMER-HSA-3000480
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
Fluid shear stress and atherosclerosisKEGGko05418
IL-17 signaling pathwayKEGGhsa04657
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182640922008OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.229
162880442005Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
184827452008Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.64
170826022006TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease.58
160153742005Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein.57
175455192007Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins.43
184112912008gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.42
126547812003Cloning and expression of the Escherichia coli K1 outer membrane protein A receptor, a gp96 homologue.39
167546842006Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses.38

Citation

Dessen P

HSP90B1 (heat shock protein 90 beta family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42684/hsp90b1