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HSP90B1 (heat shock protein 90kDa beta family member 1)

Identity

Alias_namesTRA1
tumor rejection antigen (gp96) 1
heat shock protein 90kDa beta (Grp94), member 1
Alias_symbol (synonym)GP96
GRP94
Other aliasECGP
HEL-S-125m
HEL35
HGNC (Hugo) HSP90B1
LocusID (NCBI) 7184
Atlas_Id 42684
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 104324112 and ends at 104341708 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GCNT3 (15q22.2) / HSP90B1 (12q23.3)HSP90B1 (12q23.3) / APP (21q21.3)HSP90B1 (12q23.3) / CFB (6p21.33)
HSP90B1 (12q23.3) / HSP90B1 (12q23.3)HSP90B1 (12q23.3) / PTMS (12p13.31)PATJ (1p31.3) / HSP90B1 (12q23.3)
HSP90B1 12q23.3 / CFB 6p21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSP90B1   12028
Cards
Entrez_Gene (NCBI)HSP90B1  7184  heat shock protein 90kDa beta family member 1
AliasesECGP; GP96; GRP94; HEL-S-125m; 
HEL35; TRA1
GeneCards (Weizmann)HSP90B1
Ensembl hg19 (Hinxton)ENSG00000166598 [Gene_View]  chr12:104324112-104341708 [Contig_View]  HSP90B1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166598 [Gene_View]  chr12:104324112-104341708 [Contig_View]  HSP90B1 [Vega]
ICGC DataPortalENSG00000166598
TCGA cBioPortalHSP90B1
AceView (NCBI)HSP90B1
Genatlas (Paris)HSP90B1
WikiGenes7184
SOURCE (Princeton)HSP90B1
Genetics Home Reference (NIH)HSP90B1
Genomic and cartography
GoldenPath hg19 (UCSC)HSP90B1  -     chr12:104324112-104341708 +  12q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HSP90B1  -     12q23.3   [Description]    (hg38-Dec_2013)
EnsemblHSP90B1 - 12q23.3 [CytoView hg19]  HSP90B1 - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBIHSP90B1 [Mapview hg19]  HSP90B1 [Mapview hg38]
OMIM191175   
Gene and transcription
Genbank (Entrez)AB209534 AF087988 AJ890084 AK025459 AK025862
RefSeq transcript (Entrez)NM_003299
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)HSP90B1
Cluster EST : UnigeneHs.192374 [ NCBI ]
CGAP (NCI)Hs.192374
Alternative Splicing GalleryENSG00000166598
Gene ExpressionHSP90B1 [ NCBI-GEO ]   HSP90B1 [ EBI - ARRAY_EXPRESS ]   HSP90B1 [ SEEK ]   HSP90B1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSP90B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7184
GTEX Portal (Tissue expression)HSP90B1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14625   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14625  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14625
Splice isoforms : SwissVarP14625
PhosPhoSitePlusP14625
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    HSP90 (PS00298)   
Domains : Interpro (EBI)HATPase_C    Heat_shock_protein_90_CS    Hsp90_fam    Hsp90_N    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)HATPase_c (PF02518)    HSP90 (PF00183)   
Domain families : Pfam (NCBI)pfam02518    pfam00183   
Domain families : Smart (EMBL)HATPase_c (SM00387)  
Conserved Domain (NCBI)HSP90B1
DMDM Disease mutations7184
Blocks (Seattle)HSP90B1
PDB (SRS)4NH9   
PDB (PDBSum)4NH9   
PDB (IMB)4NH9   
PDB (RSDB)4NH9   
Structural Biology KnowledgeBase4NH9   
SCOP (Structural Classification of Proteins)4NH9   
CATH (Classification of proteins structures)4NH9   
SuperfamilyP14625
Human Protein AtlasENSG00000166598
Peptide AtlasP14625
HPRD01860
IPIIPI00027230   IPI00910360   IPI00939289   IPI01012598   IPI01025644   IPI01021821   
Protein Interaction databases
DIP (DOE-UCLA)P14625
IntAct (EBI)P14625
FunCoupENSG00000166598
BioGRIDHSP90B1
STRING (EMBL)HSP90B1
ZODIACHSP90B1
Ontologies - Pathways
QuickGOP14625
Ontology : AmiGOresponse to hypoxia  toll-like receptor signaling pathway  RNA binding  calcium ion binding  protein binding  ATP binding  extracellular region  nucleus  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum lumen  endoplasmic reticulum membrane  cytosol  plasma membrane  focal adhesion  receptor-mediated endocytosis  protein transport  membrane  protein phosphatase binding  ER-associated ubiquitin-dependent protein catabolic process  midbody  retrograde protein transport, ER to cytosol  extracellular matrix  actin rod assembly  endoplasmic reticulum chaperone complex  protein folding in endoplasmic reticulum  response to endoplasmic reticulum stress  ATF6-mediated unfolded protein response  melanosome  negative regulation of apoptotic process  negative regulation of apoptotic process  regulation of phosphoprotein phosphatase activity  virion binding  perinuclear region of cytoplasm  low-density lipoprotein particle receptor binding  unfolded protein binding  sequestering of calcium ion  extracellular exosome  cellular response to ATP  endocytic vesicle lumen  
Ontology : EGO-EBIresponse to hypoxia  toll-like receptor signaling pathway  RNA binding  calcium ion binding  protein binding  ATP binding  extracellular region  nucleus  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum lumen  endoplasmic reticulum membrane  cytosol  plasma membrane  focal adhesion  receptor-mediated endocytosis  protein transport  membrane  protein phosphatase binding  ER-associated ubiquitin-dependent protein catabolic process  midbody  retrograde protein transport, ER to cytosol  extracellular matrix  actin rod assembly  endoplasmic reticulum chaperone complex  protein folding in endoplasmic reticulum  response to endoplasmic reticulum stress  ATF6-mediated unfolded protein response  melanosome  negative regulation of apoptotic process  negative regulation of apoptotic process  regulation of phosphoprotein phosphatase activity  virion binding  perinuclear region of cytoplasm  low-density lipoprotein particle receptor binding  unfolded protein binding  sequestering of calcium ion  extracellular exosome  cellular response to ATP  endocytic vesicle lumen  
Pathways : KEGGProtein processing in endoplasmic reticulum    PI3K-Akt signaling pathway    NOD-like receptor signaling pathway    Estrogen signaling pathway    Thyroid hormone synthesis    Pathways in cancer    Prostate cancer   
NDEx NetworkHSP90B1
Atlas of Cancer Signalling NetworkHSP90B1
Wikipedia pathwaysHSP90B1
Orthology - Evolution
OrthoDB7184
GeneTree (enSembl)ENSG00000166598
Phylogenetic Trees/Animal Genes : TreeFamHSP90B1
HOVERGENP14625
HOGENOMP14625
Homologs : HomoloGeneHSP90B1
Homology/Alignments : Family Browser (UCSC)HSP90B1
Gene fusions - Rearrangements
Fusion : MitelmanHSP90B1/CFB [12q23.3/6p21.33]  
Fusion: TCGAHSP90B1 12q23.3 CFB 6p21.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSP90B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSP90B1
dbVarHSP90B1
ClinVarHSP90B1
1000_GenomesHSP90B1 
Exome Variant ServerHSP90B1
ExAC (Exome Aggregation Consortium)HSP90B1 (select the gene name)
Genetic variants : HAPMAP7184
Genomic Variants (DGV)HSP90B1 [DGVbeta]
DECIPHER (Syndromes)12:104324112-104341708  ENSG00000166598
CONAN: Copy Number AnalysisHSP90B1 
Mutations
ICGC Data PortalHSP90B1 
TCGA Data PortalHSP90B1 
Broad Tumor PortalHSP90B1
OASIS PortalHSP90B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSP90B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSP90B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSP90B1
DgiDB (Drug Gene Interaction Database)HSP90B1
DoCM (Curated mutations)HSP90B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSP90B1 (select a term)
intoGenHSP90B1
Cancer3DHSP90B1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191175   
Orphanet
MedgenHSP90B1
Genetic Testing Registry HSP90B1
NextProtP14625 [Medical]
TSGene7184
GENETestsHSP90B1
Huge Navigator HSP90B1 [HugePedia]
snp3D : Map Gene to Disease7184
BioCentury BCIQHSP90B1
ClinGenHSP90B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7184
Chemical/Pharm GKB GenePA36705
Clinical trialHSP90B1
Miscellaneous
canSAR (ICR)HSP90B1 (select the gene name)
Probes
Litterature
PubMed206 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSP90B1
EVEXHSP90B1
GoPubMedHSP90B1
iHOPHSP90B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:09:53 CET 2017

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